Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR-IC within the human spinal cord

Neuroreport ◽  
2000 ◽  
Vol 11 (9) ◽  
pp. 1953-1957 ◽  
Author(s):  
Catherine Abbadie ◽  
S Humayun Gultekin ◽  
Gavril W. Pasternak
Keyword(s):  
Spinal Cord ◽  
Opioid Receptor ◽  
Splice Variant ◽  
Mu Opioid Receptor ◽  
Immunohistochemical Localization ◽  
The Novel ◽  
Carboxy Terminus ◽  
Mu Opioid ◽  
Human Spinal Cord

scholarly journals Effects of the novel, selective and low-efficacy mu opioid receptor ligand NAQ on intracranial self-stimulation in rats

2014 ◽  
Vol 232 (4) ◽  
pp. 815-824 ◽  
Author(s):  
Ahmad A. Altarifi ◽  
Yunyun Yuan ◽  
Yan Zhang ◽  
Dana E. Selley ◽  
S. Stevens Negus
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
The Novel ◽  
Receptor Ligand ◽  
Mu Opioid ◽  
Self Stimulation

scholarly journals Deciphering the Novel Role of Gαz in Mu Opioid Receptor Signaling

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Miriam Barnett ◽  
Brian Knapp ◽  
Jean Bidlack
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
The Novel ◽  
Receptor Signaling ◽  
Mu Opioid

Morphological evidence of endomorphin as an agonist for the mu-opioid receptor in the rat spinal cord

2003 ◽  
Vol 341 (2) ◽  
pp. 107-110 ◽  
Author(s):  
Qing-Ping Wang ◽  
James E. Zadina ◽  
Jian-Lian Guan ◽  
Seiji Shioda
Keyword(s):  
Spinal Cord ◽  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Morphological Evidence ◽  
Rat Spinal Cord ◽  
Mu Opioid

(101) Functional characterization of the novel alternatively spliced form of mu-opioid receptor OPRM1

2008 ◽  
Vol 9 (4) ◽  
pp. 1 ◽  
Author(s):  
P. Gris ◽  
P. Cheng ◽  
J. Gauthier ◽  
S. Shabalina ◽  
W. Maixner ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Functional Characterization ◽  
Mu Opioid Receptor ◽  
The Novel ◽  
Mu Opioid ◽  
Alternatively Spliced

scholarly journals β-Fluorofentanyls are pH-Sensitive Mu Opioid Receptor Agonists

2019 ◽  
Author(s):  
Ricardo Rosas, Jr. ◽  
Xi-Ping Huang ◽  
Bryan L. Roth ◽  
Chris Dockendorff
Keyword(s):  
Opioid Receptor ◽  
Building Blocks ◽  
Mu Opioid Receptor ◽  
Side Chain ◽  
The Novel ◽  
Commercial Building ◽  
Mu Opioid ◽  
Camp Assay ◽  
Opioid Receptor Agonists

The concept recently postulated by Stein and coworkers (Science 2017, 355, 966) that mu opioid receptor (MOR) agonists possessing amines with attenuated basicity show pH-dependent activity and can selectively act at damaged, low pH tissues has been additionally supported by in vitro studies reported here. We synthesized and tested analogs of fentanyl possessing one or two fluorine atoms at the beta position of the phenethylamine side chain, with additional fluorines optionally added to the benzene ring of the side chain. These compounds were synthesized in 1 to 3 steps from commercial building blocks. The novel bis-fluorinated analog RR-49 showed superior pH sensitivity, with full efficacy relative to DAMGO, but with 19-fold higher potency (EC<sub>50</sub>) in a MOR cAMP assay at pH 6.5 versus 7.4. Such compounds hold significant promise as analgesics for inflammatory pain with reduced abuse potential.

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