PATHOLOGICAL CHANGES OF PERIODONTAL TISSUES IN CONDITIONS OF EXPERIMENTAL MODELING OF PARODONTITIS IN RABBITS

Background. Developed local periodontitis in a laboratory rabbit was reproduced experimentally with a ligature method used. Clinical changes, peculiarities of anatomical structure and pathomorphological changes of periodontal tissues were considered at the stages of the experiment. Perfected the technique of local initiation of periodontitis around the incisors of the lower jaw was perfected with the help of ligature method by Volozhin A. I., Vinogradova S. I. modification of 1993. The features of the technique and recommendations for its implementation were stated. The possibility of using rabbits as a biological model for modeling inflammation in periodontal tissues was evaluated. Object. The aim of the study was to assess in normal conditions and to compare the pathological changes of marginal division of the gums on the stages of artificially initiated periodontitis in the rabbit with the data obtained biopsy material in humans. Materials and methods. The experiment was conducted on three rabbits of the Chinchilla breed weighing 2500 to 3000 grams, in which local periodontitis initiated according to the method of initiation of local periodontitis around the incisors of the lower jaw with ligature method by Volozhin A. I., Vinogradova S. I. modification of 1993. Clinical and histological data were collected during the experimental stages. Then they were compared with the data obtained in humans. Results. The study has identified features of technology for artificial simulation of periodontitis. Also, it has been determined that the histological tissue samples in norm and pathology, and clinical signs of developed periodontitis proved similarity of anatomical and pathological structures at marginal division of the gum for both rabbits and humans. Thus, the use of rabbits as a biological model for the modeling of periodontitis and the choice of modern methods of treatment of periodontitis is possible.