Improvement of the predictive value of CD4 + lymphocyte count by β2-microglobulin, immunoglobulin A and erythrocyte sedimentation rate

Abstract Background: Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity.Methods: Participants (n=514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and specificity and the area under the curve (AUC) for each model were determined using receiver operating characteristic curves (ROC). Multiple regressions were run to predict BD activity score from ESR and CRP.Result: Patients with active ocular, oral, genital, joint and dermal manifestations had higher ESR and CRP values (Mann-Whitney U test, p< 0.05 for all). Binomial logistic regressions showed that ESR had valuable predictive value for active BD (OR =1.09[1.04-1.13] , AUC = 0.79[0.74-0.83], p<0.001) and active vascular manifestations (1.03[1.01-1.05], AUC = 0.85[0.79-0.92], p<0.001). CRP had good predictive value for active vascular manifestations (OR 1.98[1.45-2.72], AUC = 0.86[0.8-0.91], p<0.001,). The optimal value of ESR ≥ 10.5 and ESR ≥ 42.5 could predict active BD and active vascular manifestations with Sensitivity,Specificity = 71%,75% and =81%, 83% respectively.Conclusions: ESR and CRP are both associated with active BD and most manifestations of the diseases. They can be used for the prediction of active BD and active vascular manifestations in BD patients. Further studies can help to confirm the findings of the current research.

Download Full-text

Serum anti-p24 antibody concentration has a predictive value on the decrease of CD4 lymphocyte count higher than acid-dissociated p24 antigen

Journal of Medical Virology ◽

10.1002/jmv.1890470116 ◽

1995 ◽

Vol 47 (1) ◽

pp. 87-91 ◽

Cited By ~ 6

Author(s):

L. Morand-Joubert ◽

H. Bludau ◽

J. Lerable ◽

J. C. Petit ◽

J. J. Lefrère

Keyword(s):

Predictive Value ◽

Lymphocyte Count ◽

Antibody Concentration ◽

Cd4 Lymphocyte Count ◽

P24 Antigen ◽

Cd4 Lymphocyte

Download Full-text

The Diagnosis of Osteomyelitis in Diabetes Using Erythrocyte Sedimentation Rate

Journal of the American Podiatric Medical Association ◽

10.7547/87507315-91-9-445 ◽

2001 ◽

Vol 91 (9) ◽

pp. 445-450 ◽

Cited By ~ 57

Author(s):

Jennifer L. Kaleta ◽

Jeffrey W. Fleischli ◽

Charles H. Reilly

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Diabetic Foot ◽

Predictive Value ◽

Characteristic Curve ◽

Retrospective Chart Review ◽

Diabetic Patients ◽

Optimal Cutoff ◽

Diabetic Foot Infections ◽

Erythrocyte Sedimentation

Osteomyelitis secondary to diabetic foot infections can lead to proximal amputation if not diagnosed in a timely and accurate manner. The authors have found no studies to date that correlate a specific erythrocyte sedimentation rate with osteomyelitis. A retrospective chart review of 29 diabetic patients admitted to the hospital with diagnoses of osteomyelitis or cellulitis of the foot during a 1-year period was performed. Of the various lab values and demographic factors compared, erythrocyte sedimentation rate was the only measure that differed significantly between the two groups. A receiver operating characteristic curve was used to obtain the optimal cutoff value of 70 mm/h, a level above which osteomyelitis was present with the highest sensitivity (89.5%) and highest specificity (100%), along with a positive predictive value of 100% and a negative predictive value of 83%. This study shows that in combination with clinical suspicion in diabetic foot infections, the erythrocyte sedimentation rate is highly predictive of osteomyelitis, and that the value of 70 mm/h is the optimal cutoff to predict accurately the presence or absence of bone infection. (J Am Podiatr Med Assoc 91(9): 445-450, 2001)

Download Full-text

The Predictive Value of Micro-Erythrocyte Sedimentation Rate in Neonatal Sepsis in a Low Resource Country

Pediatrics & Therapeutics ◽

10.4172/2161-0665.s2-002 ◽

2013 ◽

Vol 03 (03) ◽

Author(s):

West BA ◽

Tabansi PN ◽

Ugwu RO

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Neonatal Sepsis ◽

Predictive Value ◽

Low Resource ◽

Erythrocyte Sedimentation ◽

Low Resource Country

Download Full-text

Diagnostic and predictive value of white blood cell count, erythrocyte sedimentation rate, and coagulation tests in patients with blunt head trauma

Journal of Research in Clinical Medicine ◽

10.34172/jrcm.2020.003 ◽

2020 ◽

Vol 8 (1) ◽

pp. 3-3

Author(s):

Amir Ghaffarzad ◽

Mahboub Pouraghaei ◽

Zahra Parsian ◽

Neda Ghilani ◽

Mustafa Cicek ◽

...

Keyword(s):

Emergency Department ◽

Blood Cell ◽

Erythrocyte Sedimentation Rate ◽

Head Trauma ◽

White Blood Cell ◽

Sedimentation Rate ◽

Predictive Value ◽

Erythrocyte Sedimentation ◽

Blunt Head Trauma ◽

Coagulation Tests

Introduction: Head trauma is the third leading cause of death and one of the most common causes of referral to the emergency department. Prognosis in these patients identifies individuals at higher risk and provides them with faster and more complete treatment, so it is of particular importance. The aim of this study is to evaluate the diagnostic and predictive value of white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and coagulation tests in the outcome of patients with blunt head trauma. Methods: In this retrospective study, 91 patients referred to the emergency department of Imam Reza hospital of Tabriz, with a complaint of DAI type of blunt head trauma, were enrolled in a complete and sequential study during the first six months of the year 2017. The patientswere divided into two groups according to good or poor prognosis and their association with leukocytosis status and other paraclinical factors at the baseline. Results: The final outcome in high consciousness group was 13.3% need for intubation,26.7% need for surgery, 50% improvement without complications, and 10% mortality. In the low consciousness group, 16.7% required intubation, 20.0% required surgery, 10% had no complications, and 53.3% experienced mortality. The significance level of the chi-squaretest was 0.001. Independent t test results showed that the WBC and ESR values in the lowconsciousness group were significantly higher than the high consciousness group. But the international normalized ratio (INR) in the high consciousness group was significantly higher than the low consciousness group (P<0.05). Conclusion: There is a significant relationship between severity of injury and leukocytosis, ESRelevation, and related coagulopathy after major trauma.

Download Full-text

Predictive value of erythrocyte sedimentation rate and C-reactive protein in Behcet's disease activity and manifestations: a cross-sectional study

10.21203/rs.3.rs-822425/v1 ◽

2021 ◽

Author(s):

Amirhossein Parsaei ◽

Soroush Moradi ◽

Maryam Masoumi ◽

Fereydoun Davatchi ◽

Anahita Najafi ◽

...

Keyword(s):

Disease Activity ◽

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Predictive Value ◽

Behcet’S Disease ◽

Behçet's Disease ◽

C Reactive Protein ◽

Behcet's Disease ◽

Reactive Protein ◽

Erythrocyte Sedimentation

Abstract Background Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity. Methods Participants (n = 514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and specificity and the area under the curve (AUC) for each model were determined using receiver operating characteristic curves (ROC). Multiple regressions were run to predict BD activity score from ESR and CRP. Result Patients with active ocular, oral, genital, joint and dermal manifestations had higher ESR and CRP values (Mann-Whitney U test, p < 0.05 for all). Binomial logistic regressions showed that ESR had valuable predictive value for active BD (OR = 1.09[1.04–1.13], AUC = 0.79[0.74–0.83], p < 0.001) and active vascular manifestations (1.03[1.01–1.05], AUC = 0.85[0.79–0.92], p < 0.001). CRP had good predictive value for active vascular manifestations (OR 1.98[1.45–2.72], AUC = 0.86[0.8–0.91], p < 0.001,). The optimal value of ESR ≥ 10.5 and ESR ≥ 42.5 could predict active BD and active vascular manifestations with Sensitivity,Specificity = 71%,75% and = 81%, 83% respectively. Conclusions ESR and CRP are both associated with active BD and most manifestations of the diseases. They can be used for the prediction of active BD and active vascular manifestations in BD patients. Further studies can help to confirm the findings of the current research.

Download Full-text