Post-exposure prophylaxis with highly active antiretroviral therapy could not protect macaques from infection with SIV/HIV chimera

AIDS ◽  
2000 ◽  
Vol 14 (12) ◽  
pp. 1864-1866 ◽  
Author(s):  
Roger Le Grand ◽  
Bruno Vaslin ◽  
Jérome Larghero ◽  
Olivier Neidez ◽  
Hugues Thiebot ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Highly Active ◽  
Exposure Prophylaxis

HIV post-exposure prophylaxis after sexual assault: the experience of a sexual assault service in London

2002 ◽  
Vol 13 (9) ◽  
pp. 602-605 ◽  
Author(s):  
S Limb ◽  
M Kawsar ◽  
G E Forster
Keyword(s):  
Sexual Assault ◽  
Adverse Events ◽  
Highly Active Antiretroviral Therapy ◽  
Post Exposure Prophylaxis ◽  
Retrospective Case ◽  
Post Exposure ◽  
Highly Active ◽  
Exposure Prophylaxis ◽  
Case Note Review

Objectives: To review the provision, uptake and outcome of HIV post-exposure prophylaxis (HIV-PEP) after sexual assault. Methods: A retrospective case note review of patients attending a sexual assault service in London during 1999. Results: Ten out of 150 patients were considered eligible for PEP after a careful risk assessment. Eight patients accepted HIV-PEP. Highly active antiretroviral therapy (HAART) consisted of Combivir/indinavir in six patients and Combivir/nelfinavir in two patients. Two patients changed their combination due to adverse events. Five patients completed the recommended 28 days of treatment. Three patients discontinued therapy due to adverse events. Two patients who completed HIV-PEP were noted to have raised cholesterol at follow-up. All patients who took PEP were HIV-1 and -2 antibody negative at six months. Conclusions: Compared with other published studies the completion rate of HIV-PEP in our study was high. The uptake and adverse events of HAART in this scenario were similar to previously published studies. A multidisciplinary approach to the management of this patient group will improve adherence to PEP.

scholarly journals Post exposure prophylaxis for occupational and non occupational exposure to HIV in a tertiary care hospital in central Nepal

2018 ◽  
Vol 7 (2) ◽  
pp. 34-37
Author(s):  
Rakshya Shrestha ◽  
Sashi Sharma ◽  
Prem Khadga ◽  
Matina Sayami ◽  
Uma Chitrakar ◽  
...  
Keyword(s):  
Health Care ◽  
Antiretroviral Therapy ◽  
Occupational Exposure ◽  
Health Care Workers ◽  
Post Exposure Prophylaxis ◽  
Care Hospital ◽  
Staff Nurse ◽  
Post Exposure ◽  
Care Workers ◽  
Exposure Prophylaxis

Introduction: Post exposure prophylaxis (PEP) to HIV is the short term use of prescribed dose of antiretroviral therapy among persons exposed to high risk behaviors in order to prevent them from HIV infection. While occupationally exposed cases among health care workers are the major target of PEP, it is equally applicable to non occupational exposure to HIV including sexually exposed cases. This study was carried out to know the current scenario of PEP for HIV in terms of various determinants/ risk factors and outcomes of HIV positivity after prophylaxis. Methods: A prospective study was carried out by Antiretroviral therapy center of Tribhuvan University Teaching Hospital. The study period was between August 2006 and September 2016. Altogether 50 cases exposed to known HIV seropositive persons were included in this study. Results: The majority of the occupationally exposures were interns (48.6%), followed by staff nurse (18.9%), CMLT student (13.5%), hospital staff (10.8%) and resident doctor (8.1%). Majority (70.3%) were exposed to needle prick injury. Six-month follow-up showed zero seroconversion for HIV ELISA among the exposed cases. Conclusion: Intern constituted the greater proportion of health care workers exposed to accidental needle stick injury. Timely administration of prophylaxis might have resulted zero seroconversion for HIV ELISA among the exposed cases.

Post-exposure prophylaxis guidelines for children and adolescents potentially exposed to HIV

2016 ◽  
Vol 102 (1) ◽  
pp. 78-83
Author(s):  
Alasdair Bamford ◽  
Gareth Tudor-Williams ◽  
Caroline Foster
Keyword(s):  
Primary Care ◽  
Antiretroviral Therapy ◽  
Children And Adolescents ◽  
Emergency Departments ◽  
Secondary Care ◽  
Post Exposure Prophylaxis ◽  
Paediatric Hiv ◽  
Post Exposure ◽  
Exposure Prophylaxis ◽  
Bloodborne Viruses

UK guidelines for HIV post-exposure prophylaxis (PEP) in adults have recently been updated. Indications for PEP have been modified and there has been a change in the recommended antiretroviral therapy for adults to a combination of raltegravir with tenofovir and emtricitabine (Truvada). Raltegravir and tenofovir are now available in paediatric formulations and offer improved safety and tolerability over previously recommended ritonavir-boosted lopinavir with zidovudine. This guideline provides recommendations for those caring for children potentially exposed to HIV and other bloodborne viruses in primary care, emergency departments, secondary care and specialist paediatric HIV centres.

Prevention Strategies Against HIV Transmission: A Proactive Approach

2017 ◽  
Vol 31 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Antonio J. Carrion ◽  
Jovan D. Miles ◽  
Juan F. Mosley ◽  
Lillian L. Smith ◽  
April S. Prather ◽  
...  
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
Hiv Transmission ◽  
Hiv Infections ◽  
The United States ◽  
Post Exposure Prophylaxis ◽  
Proactive Approach ◽  
Highly Active ◽  
Department Of Health ◽  
Immunodeficiency Virus ◽  
Exposure Prophylaxis

Human immunodeficiency virus (HIV) has now transformed into a manageable chronic condition. Highly active antiretroviral therapy (HAART) has proven efficacious at controlling the disease progression. Based on compelling evidence, the Department of Health and Human Services (DHHS) and the Infectious Disease Society of America (IDSA) developed guidelines for the management of persons infected with HIV. However, there are approximately 50 000 new cases of HIV in the United States each year. In this article, we review proactive methods to reduce the transmission of HIV, which include reinforcing patient education, gel-coated condoms that destroy HIV, HIV vaccinations, and adequately utilizing pre-exposure prophylaxis (PrEP), and post-exposure prophylaxis (PEP). Further development and consistent utilization of innovative prevention tools can significantly reduce the incidence of HIV infections regardless of HIV status.

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