Intratumoral Production of Tumor Necrosis Factor Augmented by Endogenous Interferons Results in Potent Antitumor Effects of DT-5461, a Synthetic Lipid A Analog

Induction of intratumoral tumor necrosis factor by a synthetic lipid A analog, ONO-4007, with less tolerance in repeated administration and its implication in potent antitumor effects with low toxicity

10.1007/s00262-001-0241-7 ◽

2002 ◽

Vol 50 (12) ◽

pp. 653-662 ◽

Cited By ~ 8

Author(s):

Motonobu Satoh, Kazusa Tsurumaki, Hideaki Ka

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Repeated Administration ◽

Antitumor Effects ◽

Low Toxicity ◽

The Roles of Protein Phosphorylation/Dephosphorylation in Tumor Necrosis Factor Antitumor Effects

Journal of Interferon & Cytokine Research ◽

10.1089/jir.1996.16.1021 ◽

1996 ◽

Vol 16 (12) ◽

pp. 1021-1025 ◽

Cited By ~ 3

Author(s):

XIN-YUAN WANG ◽

MICHAEL KAFKA ◽

ALEXANDER DVILANSKY ◽

ILANA NATHAN

Keyword(s):

Tumor Necrosis Factor ◽

Protein Phosphorylation ◽

Tumor Necrosis ◽

Antitumor Effects ◽

Induction of Tumor Necrosis Factor in a Murine Tumor by Systemic Administration of a Novel Synthetic Lipid A Analogue ONO-4007

Journal of Immunotherapy ◽

10.1097/00002371-199701000-00007 ◽

1997 ◽

Vol 20 (1) ◽

pp. 65-66 ◽

Cited By ~ 8

Author(s):

Hiroshi Ueda ◽

Masatoshi Yamazaki

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Systemic Administration ◽

Murine Tumor ◽

MONOPHOSPHORYL LIPID A PROTECTS AGAINST GRAM-POSITIVE SEPSIS AND TUMOR NECROSIS FACTOR

Shock ◽

10.1097/00024382-199410000-00007 ◽

1994 ◽

Vol 2 (4) ◽

pp. 271-274 ◽

Cited By ~ 20

Author(s):

Mark E. Astiz ◽

Angel Galera ◽

Dhanonjoy C. Saha ◽

Charles Carpati ◽

Eric C. Rackow

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Gram Positive ◽

Monophosphoryl Lipid A ◽

Monophosphoryl Lipid ◽

Augmented Antitumor Effects of Killer Cells Induced by Tumor Necrosis Factor Gene-Transduced Autologous Tumor Cells from Gastrointestinal Cancer Patients

Human Gene Therapy ◽

10.1089/hum.1996.7.15-1895 ◽

1996 ◽

Vol 7 (15) ◽

pp. 1895-1905 ◽

Cited By ~ 8

Author(s):

Yasushi Sato ◽

Yoshikazu Koshita ◽

Michiaki Hirayama ◽

Tomohiko Matuyama ◽

Hiroaki Wakimoto ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Cancer Patients ◽

Tumor Cells ◽

Gastrointestinal Cancer ◽

Tumor Necrosis ◽

Autologous Tumor ◽

Antitumor Effects ◽

Factor Gene ◽

Tumor Necrosis Factor Gene ◽

Induction of an endogenous tumor necrosis factor in mice by murine recombinant interferon-? combined with a lipid A subunit analog (GLA-60) of low toxicity

10.1007/bf00199284 ◽

1989 ◽

Vol 29 (2) ◽

Cited By ~ 14

Author(s):

Ikuo Saiki ◽

Hiroaki Maeda ◽

Takuma Sakurai ◽

Jun Murata ◽

Joji Iida ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Recombinant Interferon ◽

A Subunit ◽

Low Toxicity ◽

Potentiation of antitumor effects of tumor necrosis factor ? and interferon ? by macrophage-colony-stimulating factor in a MmB16 melanoma model in mice

10.1007/s002620050180 ◽

1995 ◽

Vol 40 (5) ◽

pp. 315-321 ◽

Cited By ~ 4

Author(s):

W. Lasek ◽

Anna Wankowicz ◽

Katarzyna Kuc ◽

Wojciech Feleszko ◽

Jakub Golab ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Colony Stimulating Factor ◽

Antitumor Effects ◽

Melanoma Model ◽

Macrophage Colony Stimulating Factor ◽

Macrophage Colony ◽

Stimulating Factor ◽

Mechanism of action differences in the antitumor effects of transmembrane and secretory tumor necrosis factor-alpha in vitro and in vivo

10.1007/s00262-006-0150-x ◽

2006 ◽

Vol 55 (12) ◽

pp. 1470-1479 ◽

Cited By ~ 20

Author(s):

Qingfen Li ◽

Li Li ◽

Wenfang Shi ◽

Xiaodan Jiang ◽

Yong Xu ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Mechanism Of Action ◽

Tumor Necrosis ◽

Antitumor Effects ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Effects of Tumor Necrosis Factor and Dexamethasone on the Regulation of Interferon-?? Induction by Monophosphoryl Lipid A

Journal of Immunotherapy ◽

10.1097/00002371-199402000-00006 ◽

1994 ◽

Vol 15 (2) ◽

pp. 129-133 ◽

Cited By ~ 10

Author(s):

Gary L. Gustafson ◽

Michael J. Rhodes

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Lipid A ◽

Monophosphoryl Lipid A ◽

Monophosphoryl Lipid ◽

Interferon Induction ◽

Lysosome Labilizers Potentiate the Antitumor Effects of Tumor Necrosis Factor-α

Japanese Journal of Cancer Research ◽

10.1111/j.1349-7006.1993.tb00157.x ◽

1993 ◽

Vol 84 (4) ◽

pp. 451-454

Author(s):

Tsukio Masegi ◽

Arata Kato ◽

Kazuo Kitai ◽

Masami Fukuoka ◽

Kazuhiko Soma ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Antitumor Effects ◽

Factor Α ◽