Major Depressive Disorder and Panic Disorder Effects of Comorbidity on Treatment Outcome with Antidepressant Medications

1988 ◽  
Vol 11 (5) ◽  
pp. 454-461 ◽  
Author(s):  
Leon Grunhaus ◽  
Yoseph Harel ◽  
Tina Krugler ◽  
Atul C. Pande ◽  
Roger F. Haskett
Keyword(s):  
Major Depressive Disorder ◽  
Treatment Outcome ◽  
Panic Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Disorder Effects ◽  
Antidepressant Medications

scholarly journals Comorbidity of panic disorder and major depressive disorder: effects on platelet alpha2adrenergic receptors

1990 ◽  
Vol 81 (3) ◽  
pp. 216-219 ◽  
Author(s):  
L. J. Grunhaus ◽  
O. Cameron ◽  
A. C. Pande ◽  
R.F. Haskett ◽  
P. J. Hollingsworth ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Panic Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Disorder Effects

scholarly journals Effect of Cognitive Therapy With Antidepressant Medications vs Antidepressants Alone on the Rate of Recovery in Major Depressive Disorder

2014 ◽  
Vol 71 (10) ◽  
pp. 1157 ◽  
Author(s):  
Steven D. Hollon ◽  
Robert J. DeRubeis ◽  
Jan Fawcett ◽  
Jay D. Amsterdam ◽  
Richard C. Shelton ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cognitive Therapy ◽  
Major Depressive ◽  
Antidepressant Medications ◽  
Rate Of Recovery

Therapeutic alliance mediates the association between personality and treatment outcome in patients with major depressive disorder

2016 ◽  
Vol 201 ◽  
pp. 137-144 ◽  
Author(s):  
Shauna C. Kushner ◽  
Lena C. Quilty ◽  
Amanda A. Uliaszek ◽  
Carolina McBride ◽  
R. Michael Bagby
Keyword(s):  
Major Depressive Disorder ◽  
Treatment Outcome ◽  
Depressive Disorder ◽  
Therapeutic Alliance ◽  
Major Depressive

Suicidal ideation and other persisting symptoms after CBT or antidepressant medication treatment for major depressive disorder

2018 ◽  
Vol 49 (11) ◽  
pp. 1869-1878 ◽  
Author(s):  
Boadie W. Dunlop ◽  
Philip E. Polychroniou ◽  
Jeffrey J. Rakofsky ◽  
Charles B. Nemeroff ◽  
W. Edward Craighead ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Suicidal Ideation ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Antidepressant Medication ◽  
Major Depressive ◽  
Residual Symptom ◽  
Residual Symptoms ◽  
Antidepressant Medications ◽  
Item Scores

AbstractBackgroundPersisting symptoms after treatment for major depressive disorder (MDD) contribute to ongoing impairment and relapse risk. Whether cognitive behavior therapy (CBT) or antidepressant medications result in different profiles of residual symptoms after treatment is largely unknown.MethodsThree hundred fifteen adults with MDD randomized to treatment with either CBT or antidepressant medication in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study were analyzed for the frequency of residual symptoms using the Montgomery Asberg Depression Rating Scale (MADRS) item scores at the end of the 12-week treatment period. Separate comparisons were made for treatment responders and non-responders.ResultsAmong treatment completers (n= 250) who responded to CBT or antidepressant medication, there were no significant differences in the persistence of residual MADRS symptoms. However, non-responders treated with medication were significantly less likely to endorse suicidal ideation (SI) at week 12 compared with those treated with CBT (non-responders to medication: 0/54, 0%, non-responders to CBT: 8/30, 26.7%;p= .001). Among patients who terminated the trial early (n= 65), residual MADRS item scores did not significantly differ between the CBT- and medication-treated groups.ConclusionsDepressed adults who respond to CBT or antidepressant medication have similar residual symptom profiles. Antidepressant medications reduce SI, even among patients for whom the medication provides little overall benefit.

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