Induced onset time of rocuronium bromide by ephedrine hydrochloride

2001 ◽  
Vol 18 (Supplement 21) ◽  
pp. 94-95
Author(s):  
M. P. Besler ◽  
N. Bilginer ◽  
M. Gul ◽  
F. Yayci ◽  
M. Celik
Keyword(s):  
Onset Time ◽  
Rocuronium Bromide ◽  
Ephedrine Hydrochloride

scholarly journals Characteristics of neuromuscular block after administration of rocuronium bromide in patients with end-stage renal failure

2011 ◽  
Vol 139 (11-12) ◽  
pp. 765-771
Author(s):  
Nevena Kalezic ◽  
Biljana Krivic ◽  
Vladan Zivaljevic ◽  
Djordje Ugrinovic ◽  
Dijana Jovanovic ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Normal Renal Function ◽  
Neuromuscular Block ◽  
Onset Time ◽  
Cumulative Effect ◽  
Control Group ◽  
Rocuronium Bromide ◽  
Duration Time ◽  
Development Duration

Introduction. Anaesthesia affects kidney function by reducing the renal blood flow and glomerular filtration rate. As chronic renal failure (CRF) significantly influences drug metabolism and elimination, we studied the effects of rocuronium bromide (RB) in patients with CRF. Objective. The aim of the study was to examine whether, when using RB in patients with CFR, there are differences regarding the onset time of neuromuscular block (NMB) development, duration time, speed of recovery and cumulative effects of RB. Methods. Prospective study included 60 patients who underwent urologic surgery procedures. The patients were divided into 3 groups: the first group (G1) - 20 patients with CRF and residual dieresis, the second group (G2) - 20 patients with CRF and without dieresis, and third group (G3) - 20 patients with normal renal function (control group). During surgery RB was administrated for muscle paralysis in all patients. Train-of-four (TOF) Guard acceleromyography was used for NMB monitoring. Results. Onset time in three groups was 132.3 s; 139.5 s and 113.2 s (r<0.01). Duration of intubation dose was the same in G1 and G2 (28.9 minutes), while in the third group it was 27.2 minutes (r>0.05). The number of RB repeated doses was 3-8, 3-7 and 4-8 (r>0.05). The duration time until spontaneous recovery was 31.8, 31.6 and 29.8 minutes (r>0.01). The recovery index was 16.8, 16.7 and 10.6 minutes (r<0.001). The duration time from the last dose of RB to extubation was 74.5, 74.8 and 58.9 minutes (r<0.001). Conclusion. In patients with CRF the cumulative effect of the drug was registered, with a prolonged recovery time from NMB in relation to the patients with normal renal function.

scholarly journals Evaluation of the Onset Time and Intubation Conditions of Rocuronium Bromide in Children

1997 ◽  
Vol 25 (3) ◽  
pp. 260-261 ◽  
Author(s):  
P. F. McDonald ◽  
D. A. Sainsbury ◽  
R. J. Laing
Keyword(s):  
Onset Time ◽  
Adductor Pollicis ◽  
Rocuronium Bromide ◽  
Intubating Conditions ◽  
Train Of Four ◽  
The Mean

We have assessed, in children aged three to eight years, the intubating conditions after administration of rocuronium 0.6 mg/kg at 50 or 60 seconds, in groups of 15 patients. Intubating conditions were excellent in 11, good in 3 and fair in 1 patient at 50 seconds and excellent in 12 and good in 3 patients at 60 seconds. The mean onset time, for all patients, to when the first twitch of the train of four (T1), measured at the adductor pollicis, was depressed to less than 30% and 5% of control was 50 (SD 11.4) seconds and 94 (SD 31.7) seconds respectively. Depression of T1 to less than 30% of control, measured at the adductor pollicis in children, appears to indicate that intubating conditions will be clinically acceptable when using rocuronium.

scholarly journals COMPARISON OF HEMODYNAMIC AND NEUROMUSCULAR PROPERTIES OF ROCURONIUM VERSUS VECURONIUM IN ANESTHESIA

2021 ◽  
pp. 1-3
Author(s):  
Rajeev Krishan ◽  
Praveen Kumar Singh ◽  
Chandeshwar Choudhary ◽  
Debarshi Jana
Keyword(s):  
Blood Pressure ◽  
General Anesthesia ◽  
Onset Time ◽  
Cardiovascular Effects ◽  
Neuromuscular Blocking ◽  
Vecuronium Bromide ◽  
Rocuronium Bromide ◽  
Duration Of Action ◽  
Hemodynamic Variables ◽  
Significant Difference

Background: Adequate maintenance of airways in patients undergoing surgeries under general anesthesia was through proper intubation. This was achieved by the extensive usage of neuromuscular blocking drugs, which provided good intubation conditions and relaxation of the muscles. Neuromuscular blockers play a key role in general anesthesia. Rocuronium and vecuronium are used as nondepolarizing muscle relaxants. Objective: To study the neuromuscular properties and cardiovascular effects of rocuronium bromide, the “near-ideal” muscle relaxant and to compare it with vecuronium bromide, an already established drug, during anesthesia. Materials and Methods: This prospective, randomized double-blinded clinical study included 50 patients, 25 patients received 0.6 mg/kg of rocuronium bromide for the maintenance of anesthesia and the other 25 patients received 0.1 mg/kg of vecuronium bromide. The top-up doses administered were 0.15 mg/kg of rocuronium and 0.025 mg/kg of vecuronium. Result: The onset time was significantly shorter in the rocuronium group (Mean ± standard deviation [SD] was 108.8 s ± 28.875 s) compared with vecuronium group (Mean ± SD 188.76 s± 43.78 s). The duration of action of first dose was significantly longer in rocuronium group (31.5 min) compared with vecuronium group (24.5 min).The duration of action of top-up doses was similar in both the groups (p>0.05). There was no significant difference in any of the haemodynamic variables between the two groups. Conclusion: The duration of action of top-up doses was similar in both the groups (p > 0.05). There was no significant difference in any of the hemodynamic variables (heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure) between the two groups.

scholarly journals The effect of various dilute administration of rocuronium bromide on both vascular pain and pharmacologic onset: A randomized controlled trial

2019 ◽  
Author(s):  
Mayuko Kanazawa ◽  
Aiji Sato(Boku) ◽  
Yoko Okumura ◽  
Mayumi Hashimoto ◽  
Naoko Tachi ◽  
...  
Keyword(s):  
Evaluation Method ◽  
Controlled Trial ◽  
Muscle Relaxation ◽  
Onset Time ◽  
Rocuronium Bromide ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Vascular Pain ◽  
Group 1

Abstract Background: Rocuronium bromide (RB) is known to cause vascular pain. Although there have been a few reports that diluted administration causes less vascular pain, there have been no studies investigating diluted administration and the onset time of muscle relaxation. Therefore, we examined the influence of diluted administration of RB on the onset time of muscle relaxation and vascular pain. Methods: 39 patients were randomly assigned to three groups: RB stock solution 10 mg/ml (Group 1), two-fold dilution 5 mg/ml (Group 2), or three-fold dilution 3.3 mg/ml (Group 3). After the largest vein of the forearm was secured, anesthesia was induced by propofol and 0.6 mg/kg of RB was administered. The evaluation method devised by Shevchenko et al. was used to evaluate the degree of vascular pain. The time from RB administration until the maximum blocking of T1 by TOF stimulation was measured. Results: There was no significant difference in escape behaviors of vascular pain among the three groups, and the onset time of muscle relaxation was significantly slower in Group 3 than in Group 1 (p=0.035). Conclusion: Our results suggested that it is unnecessary to dilute RB before administration if a large vein in the forearm is used. Trial Registration: UMINCTR Registration number UMIN000026737, Registered 28 Mar 2017 Keywords: Rocuronium bromide, Diluted administration, Onset time, Vascular pain

Stimulus onset-to-onset time determines the dichotic temporal order threshold

2001 ◽  
Author(s):  
Harvey Babkoff ◽  
Elisheva Ben-Artzi ◽  
Leah Fostick
Keyword(s):  
Temporal Order ◽  
Onset Time ◽  
Stimulus Onset
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