Botulinum Toxin Injection for Painful Adductor Pollicis Contracture after Thumb Carpometacarpal Resection Arthroplasty

Pollux adductus deformity is an accompanying symptom of thumb carpometacarpal osteoarthritis. We describe a case of a patient who presented with increased muscle tone of the adductor pollicis muscle and chronic pain in the thenar musculature, i.e., recurrence of an adduction deformity. The patient reported a symptom-free period of 5.5 years after having received resection-suspension-arthroplasty for stage IV thumb carpometacarpal osteoarthritis until spasmodic pain appeared. Due to the functional impairment of this condition, we administered therapy including 100 units of Botox® (onabotulinumtoxinA, Allergan, Dublin, Ireland) injected with a fanning technique into the adductor pollicis muscle. Thus, we observed a substantial improvement in the patient-reported outcome measures as well as pain levels compared with initial values. The current case shows the pivotal role of the adductor pollicis muscle when patients report pain at the base of the thumb, which can cause considerable impairments despite the complication-free surgical treatment of thumb CMC OA.

A Comparison Between the Adductor Pollicis Muscle and the Abductor Digiti Minimi Muscle Using Electromyography AF-201P in Rocuronium-Induced Neuromuscular Block: A Prospective Comparative Study

Background The AF-201P, a new electromyography (EMG)-based neuromuscular monitor has been developed recently. The aim of this clinical study was to compare two ulnar nerve innervated muscles: the adductor pollicis (AP) muscle and the abductor digiti minimi (ADM) muscle during the recovery from rocuronium-induced neuromuscular block by using EMG AF-201P. Methods Twenty patients undergoing surgery with general anesthesia were enrolled in the study. During total intravenous general anesthesia, train-of-four (TOF) and post-tetanic counts (PTC) responses following 0.9 mg/kg rocuronium administration were concurrently monitored at the AP and the ADM muscles with EMG AF-201P on the opposite arms. At the end of the surgery, sugammadex 2 mg/kg was administered when TOF counts of 2 was observed at both muscles. The primary outcome of the study was time from administration of rocuronium to first appearance of PTC response (first PTC). The secondary outcomes of the study were time from administration of rocuronium to first reappearance of TOF response (first TOF), time from first PTC to first TOF (PTC-TOF time), time to reappearance of TOF counts of 2, and time from administration of sugammadex to TOF ratio ≥ 0.9. Agreement between the two muscles was assessed using the Bland-Altman analysis. Data are expressed as mean ± standard deviation. Results Nineteen patients were included in the analysis. Time for appearance of the first PTC was significantly faster at the ADM muscle than the AP muscle (32.4 ± 13.1min vs 24.4 ± 11.4min, p = 0.006). Interval time between the first PTC and the first TOF was significantly longer with the ADM muscle than the AP muscle (19.4 ± 7.3min vs 12.4 ± 10.6min, p = 0.019). There were no significant differences in time to TOF counts of 2 and sugammadex-facilitated recovery between the two muscles. Bland-Altman analyses showed acceptable ranges of bias and limits of agreement of the two muscles. Conclusions The ADM muscle showed a good agreement with the AP muscle during rocuronium-induced neuromuscular block but faster recovery of PTC response when using EMG. Trial registration : UMIN-CTR (Registration No. UMIN000044904). Registered 19 July 2021 -Retrospectively registered,

Comparison between the trapezius and adductor pollicis muscles as an acceleromyography monitoring site for moderate neuromuscular blockade during lumbar surgery

Acceleromyography at the adductor pollicis located in a distal part of the body may not reflect the degree of neuromuscular blockade (NMB) at the proximally located muscles manipulated during lumbar surgery. We investigated the usefulness and characteristics of acceleromyographic monitoring at the trapezius for providing moderate NMB during lumbar surgery. Fifty patients were randomized to maintain a train-of-four count 1–3 using acceleromyography at the adductor pollicis (group A; n = 25) or the trapezius (group T; n = 25). Total rocuronium dose administered intraoperatively [mean ± SD, 106.4 ± 31.3 vs. 74.1 ± 17.6 mg; P < 0.001] and surgical satisfaction (median [IQR], 7 [5–8] vs. 5 [4–5]; P < 0.001) were significantly higher in group T than group A. Lumbar retractor pressure (88.9 ± 12.0 vs. 98.0 ± 7.8 mmHg; P = 0.003) and lumbar muscle tone in group T were significantly lower than group A. Time to maximum block with an intubating dose was significantly shorter in group T than group A (44 [37–54] vs. 60 [55–65] sec; P < 0.001). Other outcomes were comparable. Acceleromyography at the trapezius muscle during lumbar surgery required a higher rocuronium dose for moderate NMB than the adductor pollicis muscle, thereby the consequent deeper NMB provided better surgical conditions. Trapezius as proximal muscle may better reflect surgical conditions of spine muscle.

Comparison between the trapezius and adductor pollicis muscles as an acceleromyography monitoring site for moderate neuromuscular blockade during lumbar surgery

Acceleromyography at the adductor pollicis located in a distal part of the body may not reflect the degree of neuromuscular blockade (NMB) at the proximally located muscles manipulated during lumbar surgery. We investigated the usefulness and characteristics of acceleromyographic monitoring at the trapezius for providing moderate NMB during lumbar surgery. Fifty patients were randomized to maintain a train-of-four count 1–3 using acceleromyography at the adductor pollicis (group A; n = 25) or the trapezius (group T; n = 25). Total rocuronium dose administered intraoperatively [mean ± SD, 106.4 ± 31.3 vs. 74.1 ± 17.6 mg; P < 0.001] and surgical satisfaction (median [IQR], 7 [5–8] vs. 5 [4–5]; P < 0.001) were significantly higher in group T than group A. Lumbar retractor pressure (88.9 ± 12.0 vs. 98.0 ± 7.8 mmHg; P = 0.003) and lumbar muscle tone in group T were significantly lower than group A. Time to maximum block with an intubating dose was significantly shorter in group T than group A (44 [37–54] vs. 60 [55–65] sec; P < 0.001). Other outcomes were comparable. Acceleromyography at the trapezius muscle during lumbar surgery required a higher rocuronium dose for moderate NMB than the adductor pollicis muscle, thereby providing better surgical conditions. Trapezius as proximal muscle better reflects surgical conditions of spine muscle.

A espessura do músculo adutor do polegar não está associada a Proteína C Reativa em pacientes com câncer hospitalizados

Objective: To evaluate the association between blood of C-reactive protein concentrations and an indicator of muscle mass in hospitalized cancer patients. Methods: A cross-sectional study carried out with 110 patients of both sexes, aged ≥18 years, with solid and/or liquid cancer undergoing clinical and/or surgical treatment. Clinical and socioeconomic data were obtained from medical records. The adductor pollicis muscle thickness was obtained using skinfold caliper. Patients were divided into two groups: altered adductor pollicis muscle thickness (<13.4 mm) and normal adductor pollicis muscle thickness (≥13.4 mm). Logistic regression was performed to verify the association between adductor pollicis muscle thickness and C-reactive protein. Results: It was observed that 90% (n = 100) of the patients were classified with reduced adductor pollicis muscle thickness, higher prevalence of the solid tumor, low usual weight, current weight, and body mass index. The logistic regression analysis showed no association between the adductor pollicis muscle thickness and C-reactive protein concentrations, in any of models used: model without adjustment (OR: 1.01; 95% CI [0.94-1.09], p = 0.65); adjusted for sex and age (OR: 1.01; 95% CI [0.94-1.09], p = 0.61); and adjusted model for sex, age and body mass index (BMI) (OR: 1.04; 95% CI [0.96-1.13], p = 0.29). Conclusion: Although adductor pollicis muscle thickness is validated method for nutritional assessment, we did not find an association with the inflammation marker (C-reactive protein).