206 THE CHRONIC CANNULATION OF RAT JUGULAR VEIN TO INSURE INTRAVENOUS INJECTION AND TO SIMPLIFY REPEATED DOSE DELIVERY OR BLOOD WITHDRAWAL

1986 ◽  
Vol 21 (9) ◽  
pp. S52
Author(s):  
Sami S. Zoghbi ◽  
Alexander Gottschalk
Keyword(s):  
Intravenous Injection ◽  
Jugular Vein ◽  
Repeated Dose ◽  
Dose Delivery ◽  
Blood Withdrawal ◽  
Chronic Cannulation

scholarly journals A non-surgical jugular catheterization technique for multiple blood sampling in cats

2003 ◽  
Vol 37 (3) ◽  
pp. 188-192 ◽  
Author(s):  
G. A. Albarellos ◽  
R. R. Bonafine ◽  
V. E. Kreil ◽  
L. A. Ambros ◽  
L. Montoya ◽  
...  
Keyword(s):  
Jugular Vein ◽  
Clinical Signs ◽  
Blood Sampling ◽  
Pharmacokinetic Studies ◽  
Blood Withdrawal ◽  
Needle Type ◽  
Catheterization Technique ◽  
Minimal Damage ◽  
Multiple Blood ◽  
Indwelling Time

In order to perform pharmacokinetic studies involving multiple blood sampling, repeated at variable intervals of time, a simple and reliable non-surgical jugular catheterization technique was developed. Six cats were catheterized 48 times using an indwelling through-the-needle type catheter (22G and 20.3 cm) placed into the jugular vein through an over-the-needle type (20G and 32 mm). Catheters remained in place for 1–13 days (median 3 days) without loss of patency until removal. Each jugular was catheterized a range of 2–6 times, with a total indwelling time of 4–33 days. No clinical signs of phlebitis, thrombosis or sepsis were observed either during or after the studies. This technique allows an easy, non-painful, non-stressful blood withdrawal during extended sampling periods, with minimal damage of the veins.

EFFECTS OF AN INTRAVENOUS INJECTION OF TETRACOSACTID ON PLASMA CORTICOSTEROID AND TESTOSTERONE LEVELS IN UNSTRESSED MALE RABBITS

1979 ◽  
Vol 91 (3) ◽  
pp. 511-518 ◽  
Author(s):  
K. W. Faulborn ◽  
M. Fenske ◽  
L. Pitzel ◽  
A. König
Keyword(s):  
Body Weight ◽  
Intravenous Injection ◽  
Plasma Levels ◽  
Plasma Testosterone ◽  
Rapid Rise ◽  
Testosterone Concentration ◽  
Testosterone Levels ◽  
Blood Withdrawal ◽  
Basal Plasma ◽  
Pre Treatment

ABSTRACT Administration of tetracosactid into male rabbits, fitted with permanently indwelling jugular catheters, resulted in a rapid rise of plasma corticosteroids and plasma testosterone. Corticosteroid concentrations were significantly elevated at 40 and 60 min and testosterone concentrations 20 min after the iv injection of tetracosactid (2.5, 5.0, and 10.0 μg/kg body weight), in comparison to pre-treatment levels. Corticosteroid values in plasma were elevated as long as 120 min after tetracosactid injection. In contrast, testosterone levels were lower at 60–120 min after tetracosactid injection than corresponding pre-treatment values. However, these differences were not significant. At the doses used no tetracosactiddose-dependent corticosteroid or testosterone release could be found; apparently, testosterone release is only dependent upon basal plasma levels but not upon the dose of tetracosactid applied. From these studies it is concluded that tetracosactid may bring about an increase or decrease of testosterone concentration in plasma in the buck depending upon the length of time elapsing between injection of tetracosactid and blood withdrawal.

The Effect of Phosphorus32, Dextran, Reserpine and Stypturon on Thrombus Formation in Rats

1961 ◽  
Vol 05 (03) ◽  
pp. 543-552 ◽  
Author(s):  
J. G Ashwin ◽  
L. B Jaques
Keyword(s):  
Quantitative Evaluation ◽  
Intravenous Injection ◽  
Jugular Vein ◽  
Thrombus Formation ◽  
Direct Relation ◽  
Platelet Counts

SummaryThe effect of the radioisotope P32, hydrolysed dextran, reserpine, stypturon on thrombus formation was determined by injecting these substances into rats before a standardized operation on the jugular vein. 5 hours after the operation 65% of control animals showed a thrombus. 10 days after intravenous injection of 2, 3, or 4 µC/g, the incidence of thrombosis was lowered in direct relation with the reduced platelet counts varying from 65% incidence for counts above 200 000/mm3 to 0% incidence for counts less than 38 000/mm3. Animals injected with dextran, 2 hours, or reserpine, 48 hours before the operation had an incidence of thrombosis of 48% (P <0.01). The incidence of thrombosis was not significantly lowered by mecholyl, producing a hypotension similar to that after dextran, nor by stypturon. The importance of the method for the quantitative evaluation of substances having an effect on thrombus formation is emphasized.

scholarly journals A technique for intravenous injection in the red-eared turtle (Pseudemys scripta elegans)

1976 ◽  
Vol 10 (4) ◽  
pp. 399-401 ◽  
Author(s):  
Margriet G. Vos-Maas ◽  
P. Zwart
Keyword(s):  
Intravenous Injection ◽  
Induction Time ◽  
Surgical Procedure ◽  
Recovery Time ◽  
Intramuscular Injection ◽  
Chloral Hydrate ◽  
Jugular Vein ◽  
Sodium Pentobarbital ◽  
Muscular Relaxation ◽  
Pseudemys Scripta

A technique is described for exposure and injection of the jugular vein in the red-eared turtle. Satisfactory anaesthesia and muscular relaxation for this procedure was obtained by intramuscular injection of a mixture of chloral hydrate and sodium pentobarbital at a dose of 2.5 ml/kg bodyweight. Induction time was 30-45 minutes. Time for surgical procedure 30-45 minutes. Recovery time 1-8 hours.

Techniques for the chronic cannulation of the jugular vein in mice

1979 ◽  
Vol 11 (1) ◽  
pp. 115-117 ◽  
Author(s):  
J.E. Barr ◽  
D.B. Holmes ◽  
L.J. Ryan ◽  
S.K. Sharpless
Keyword(s):  
Jugular Vein ◽  
Chronic Cannulation

A procedure for intravenous injection using external jugular vein in Mongolian gerbil (Meriones unguiculatus)

2007 ◽  
Vol 41 (3) ◽  
pp. 403-405 ◽  
Author(s):  
D Kakol Palm ◽  
P Holländer
Keyword(s):  
Medical Research ◽  
Intravenous Injection ◽  
Intravenous Administration ◽  
Mongolian Gerbil ◽  
Jugular Vein ◽  
Pectoral Muscle ◽  
Meriones Unguiculatus ◽  
External Jugular Vein ◽  
Tail Vein Injection ◽  
Extensive Surgery

The Mongolian gerbil is commonly used in medical research. Intravenous administration of compounds in gerbils is difficult as tail vein injection sites are not visible. The present study describes a method for intravenous administration into the jugular vein in Mongolian gerbil by using an 'over-the-needle' catheter under anaesthesia. The catheter penetrates the pectoral muscle and is easily inserted into the vein. The method is simple and avoids extensive surgery in the animals.

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