Percutaneous Radio-frequency Ablation Therapy Using a Clustered Electrode for Malignant Liver Tumors

Objective: to perform a comparative analysis of postoperative complications and hospital stay terms of in-patients with malignant liver tumors after atypical liver resection and locoregional radiofrequency ablation of liver metastases.Material and methods. We analyzed the data of 295 patients with malignant liver tumors who had undergone surgical resection or radiofrequency ablation of tumor nodes.Results. We have systemized the direct results of locoregional radiofrequency ablation under sonographic control and liver resection. 45 patients (17.8 %) after liver resection and 1 (2.3 %) patient after radiofrequency ablation developed grade III–IV complications according to the Clavien-Dindo classification. The frequency of complications is statistically significantly lower after radiofrequency ablation. The duration of hospital stay after radiofrequency ablation therapy was 4.5 ± 2.5 days. After surgical liver resection, patients stayed in hospital for 10.7 ± 2.3 days.Conclusion. Locoregional therapy provides a statistically significant reduction in the incidence of complications and reduces the duration of hospital stay compared to liver surgery.

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Microwave Ablation Therapy of Malignant Liver Tumors Adjacent to the Gallbladder

Microwave Ablation Treatment of Solid Tumors ◽

10.1007/978-94-017-9315-5_8 ◽

2014 ◽

pp. 89-97

Author(s):

Hui Huang ◽

Jie Yu ◽

Ping Liang

Keyword(s):

Microwave Ablation ◽

Liver Tumors ◽

Ablation Therapy ◽

Malignant Liver Tumors ◽

Malignant Liver

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Design of the needle-driven robot for radio frequency ablation therapy based on ultrasound navigation

International Journal of Computer Applications in Technology ◽

10.1504/ijcat.2011.043886 ◽

2011 ◽

Vol 42 (1) ◽

pp. 65

Author(s):

Qinjun Du ◽

Xueyi Zhang ◽

Hui Chen

Keyword(s):

Radio Frequency ◽

Radio Frequency Ablation ◽

Ablation Therapy

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Malignant Liver Tumors in Childhood

Cancer in Childhood ◽

10.1007/978-1-4684-2070-8_22 ◽

1973 ◽

pp. 166-170

Author(s):

Sigmund H. Ein ◽

Clinton A. Stephens

Keyword(s):

Liver Tumors ◽

Malignant Liver Tumors ◽

Malignant Liver

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Horizons of development of immunotherapy for malignant liver tumors

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-191-7-81-89 ◽

2021 ◽

pp. 81-89

Author(s):

V. E. Mukhin ◽

Yu. S. Konstantinova ◽

R. R. Gimadiev ◽

N. V. Mazurchik

Keyword(s):

Liver Tumors ◽

Surgical Excision ◽

Malignant Neoplasms ◽

Therapeutic Approaches ◽

Liver Malignancies ◽

Primary Liver Tumors ◽

Malignant Liver Tumors ◽

Malignant Liver ◽

Methods Of Treatment ◽

New Strategies

Primary liver tumors are one of the most common types of malignant neoplasms. Surgical excision is still the most effective treatment in the early stages of the disease, however in most cases early diagnosis is difficult. Moreover, even if the treatment is carried out according to a radical program, the risk of relapse remains extremely high. In this regard, the search for new strategies for the treatment of liver malignancies that differ from traditional methods of treatment is not terminated. One of such promising approaches is immunotherapy. The present review is devoted to the current understanding of the mechanisms of action and the available clinical experience in the use of immunotherapy approaches in the treatment of liver malignancies. Combining different types of immunotherapy or combining immunotherapy with traditional therapeutic approaches can facilitate a synergistic effect and contribute to the development of personalized medicine.

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Use of Saline Injection to Create Large Thermal Lesions During Radio Frequency Ablation Therapy: 2. Experimental Results

10.1115/imece2001/htd-24427 ◽

2001 ◽

Author(s):

Lissa P. Silver ◽

Patrick S. Hamilton ◽

Angela C. Ni ◽

Roberto M. Aimi ◽

Michael G. Curley

Keyword(s):

Heat Transfer ◽

Radio Frequency ◽

Liver Tumors ◽

Treatment Options ◽

Left Ventricular ◽

Electrode Site ◽

Experimental Results ◽

Interface Temperature ◽

Invasive Treatment ◽

Ablation Therapy

Abstract Tissue charring during radio frequency (RF) therapy causes an impedance rise and prevents further tissue heating from occurring, thereby limiting the size of lesions that can be created. The ability to create very large lesions would provide minimally invasive treatment options for deep tissue left ventricular arrythmias and otherwise-untreatable large liver tumors. Adding convection as a method of heat transfer by injecting saline at the RF electrode site acts to both clamp the electrode/tissue interface temperature and carry energy deeper into the tissue. We have developed a RF system that uses both conduction and convection simultaneously to both enhance the amount of heat transfer and prevent or greatly delay the onset of charring. Here we confirm the heat transfer augmentation of convection with experimental results in skeletal muscle, liver, and myocardium.

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