ACUTE EFFECT OF ATI RECEPTOR BLOCKER TELMISARTAN ON ARTERIAL STIFFNESS AND LEFT VENTRICULAR FUNCTION

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S24
Author(s):  
Antonio Delgado Leon ◽  
S Celis Carrero ◽  
A Delgado Almeida ◽  
C Delgado Leon
Keyword(s):  
Arterial Stiffness ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Acute Effect ◽  
Left Ventricular ◽  
Receptor Blocker

Endovascular treatment of peripheral artery disease is associated with improved central hemodynamics and ventricular function

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Messiha ◽  
L Halfmann ◽  
O Azizy ◽  
M Steinmetz ◽  
T Rassaf ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Left Ventricular Function ◽  
Endovascular Treatment ◽  
Ventricular Function ◽  
Peripheral Artery Disease ◽  
Cardiovascular Mortality ◽  
Left Ventricular ◽  
Central Hemodynamics ◽  
Peripheral Artery ◽  
Artery Disease

Abstract Background Peripheral artery disease (PAD) is a major manifestation of atherosclerosis and a risk factor for morbidity and mortality. PAD itself is associated with increased arterial stiffness with impact on cardiac functions. Previous studies have demonstrated that augmentation index (AIx) and central blood pressure (CBP) correlate with increased cardiovascular mortality. This mechanism has been described as arterio-ventricular (AV) coupling with altered ventricular afterload and a depressed ventricular function, measured by global longitudinal strain (GLS). The impact of PAD-related endovascular treatment on arterial stiffness, central hemodynamics and potential impact on AV coupling has not been elucidated until now. Purpose Aim of the study was to investigate, if endovascular treatment of PAD improves cardiac function via enhanced central hemodynamics and AV coupling. Methods To this aim 77 patients with known symptomatic PAD who underwent interventions in the iliac and femoropopliteal arteries were included in a cross-sectional study. AIx, CBP and GLS were determined using dedicated waveform analysis and echocardiography before and after endovascular treatment. Results Mean age was 65.1±10.4 years with 66.2% male patients. Symptoms were classified by Fontaine classification (stage IIb 80.7%, stage III 5.8% and stage IV 13.5%). Iliac vessel intervention was performed in 16 and femoropopliteal intervention in 61 cases. A stentless approach was feasible in 55 patients with DCB treatment and atherectomy. After endovascular treatment, peripheral perfusion was enhanced (ABI 0.45±0.6 vs 0.81±0.5, p<0.0001). Moreover, central hemodynamics were improved (AIX 33.7±3% vs 27.9±2%, p=0.0008; AP 17.8±2 mmHg vs 14.0±2 mmHg, p=0.0004; central PP 52.4±6 mmHg vs 46.4±6 mmHg, p=0.0001). Impressively, left ventricular function was also significantly improved (GLS −15.7±2.3% vs −17.1±2.8%, p=0.005) with an improvement in AV coupling (PWV/GLS ratio −0.58m/sec% vs −0.56m/sec%, p<0.01). Conclusion Our results demonstrate that endovascular treatment of the peripheral vessels is associated with an improvement of central hemodynamics and left ventricular function via enhanced AV coupling. These prognostic relevant markers of cardiovascular disease could point to an overall potential mortality benefit through PAD treatment. Further investigation of the underlying mechanisms of AV coupling in the setting of endovascular treatment of PAD with impact on cardiovascular mortality is needed in this high-risk population. Funding Acknowledgement Type of funding source: None

scholarly journals Impact of Statin Therapy on Left Ventricular Function and Carotid Arterial Stiffness in Patients With Hypercholesterolemia

2007 ◽  
Vol 72 (4) ◽  
pp. 538-544 ◽  
Author(s):  
Yukio Mizuguchi ◽  
Yoshifumi Oishi ◽  
Hirokazu Miyoshi ◽  
Arata Iuchi ◽  
Norio Nagase ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Left Ventricular Function ◽  
Statin Therapy ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Carotid Arterial

scholarly journals HEART VESSEL COUPLING IN SUBJECT WITH RISK FACTORS: A LONGITUDINAL LEFT VENTRICULAR FUNCTION AND ARTERIAL STIFFNESS STUDY

2010 ◽  
Vol 55 (10) ◽  
pp. A167.E1562
Author(s):  
Concetta Zito ◽  
Maurizio Cusmà Piccione ◽  
Gianluca Di Bella ◽  
Raffaella Iudicello ◽  
Caterina Longordo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arterial Stiffness ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular

scholarly journals The Acute Effect of Aminophylline on Left Ventricular Function in Patients with Heart Failure

1967 ◽  
Vol 8 (2) ◽  
pp. 121-131 ◽  
Author(s):  
Hideo UEDA ◽  
Atsuo NAKANISHI ◽  
Masamitsu SHIBA ◽  
Iwao ITO ◽  
Hiroshi TSUYUKI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Acute Effect ◽  
Left Ventricular ◽  
Patients With Heart Failure

Abstract P198: Short Sleep Duration, Greater Cognitive Arousal, And Eveningness Are Associated With Reduced Left Ventricular Function In Insomnia Disorder

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Megan E Petrov ◽  
Kimiya Kasraeian ◽  
Nana Jiao ◽  
Shawn Youngstedt ◽  
farouk mookadam ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Left Ventricular ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Cognitive Arousal ◽  
Insomnia Disorder

Aim: Insomnia is associated with cardiovascular disease (CVD), particularly the phenotype with objective short sleep duration and associated physiological arousal. However, what objective sleep and arousal characteristics among patients with insomnia are related to markers of cardiovascular structure and function remains unknown. The present study examined the association of objective sleep metrics and self-reported arousability with arterial stiffness, endothelial function, and left ventricular function among patients with insomnia disorder. Methods: Sixteen young, healthy adults (age: M [ SD ]=30[7]; 56.3% women) meeting diagnostic criteria for insomnia disorder and reporting no history of CVD, underwent fasting vascular testing including carotid-femoral pulse wave velocity (cfPWV) to assess arterial stiffness (SphymocorXCEL TM ), brachial-artery flow mediated dilation (FMD) to assess endothelial function, and 2D echocardiography to assess left ventricular function (Terason uSmart 3300 TM ). Left ventricular function was assessed by ejection fraction (EF), global longitudinal strain (GLS), mitral valve E/e’ (MVE/e’), and lateral e’ using standardized methods. Ten participants wore a portable sleep monitor for 1 night (WatchPat200, Itamar Medical) and an actigraph for 8 nights (Actiwatch Spectrum Plus, Philips Respironics). All participants completed the Pre Sleep Arousal Scale (PSAS; somatic & cognitive subscales), and the Arousal Predisposition Scale (APS). Bivariate correlations and curvilinear regressions (total sleep time [TST] only) were conducted for the associations between actigraphy-assessed TST and WatchPat (WP) TST, actigraphy-assessed mean bedtime, and PSAS and APS scores with cardiovascular markers. Each set of one sleep metric with all six cardiovascular markers were Bonferroni corrected (α level: p <0.007). Results: On average, participants obtained 7h,9min of TST (range: 6h,26min - 8h,41min) and went to bed at 23:40 (range:21:47-2:13) via actigraphy, and slept 6h,51min via WP. Mean PSAS Somatic, PSAS Cognitive, and APS scores were 13.7(SD=4.5), 24.5(SD=7.5), and 27.9(SD=7.6), respectively. cfPWV (range:4.6-8.0), EF% (range:55.0-70.9), GLS% (range:-25- -19), and MVE/e’ (range:3.6-13.3) were all within age and sex normative ranges. Mean FMD was 7.8% (SD=2.6, range:4.4-14.6), and lateral e’ was 15 cm/s (SD=4.5, range:9-22). Correlations indicated that greater PSAS cognitive scores were related to worsening (less negative) GLS% ( r =0.77, p =0.001), later bedtimes were associated with lower lateral e’ ( r =-0.84, p =0.004), and shorter WPTST was associated with lower EF% (r=0.84, p=0 . 002). Conclusion: Among young adults with insomnia disorder, greater cognitive arousal, later bedtimes, and shorter objective total sleep time were associated with subclinical worsening of left ventricular strain, diastolic and systolic function.

Alpha 1-adrenergic constriction limits coronary flow and cardiac function in running dogs

1986 ◽  
Vol 250 (6) ◽  
pp. H1117-H1126 ◽  
Author(s):  
P. A. Gwirtz ◽  
S. P. Overn ◽  
H. J. Mass ◽  
C. E. Jones
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Cardiac Function ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Coronary Blood Flow ◽  
Coronary Flow ◽  
Left Ventricular ◽  
Receptor Blocker ◽  
Adrenergic Blockade

Modulation of coronary blood flow and cardiac function by alpha 1-adrenergic receptors was examined in dogs during strenuous exercise. Fifteen dogs were chronically instrumented to measure left circumflex blood flow, heart rate, regional left ventricular function (systolic shortening, and rate of shortening), and global left ventricular function (left ventricular pressure, and dP/dt). The specific postsynaptic alpha 1-receptor blocker prazosin (0.5 mg) and nonselective alpha-receptor blocker phentolamine (1.0 mg) were injected through an indwelling circumflex artery catheter to produce local adrenergic blockade of the posterior left ventricular region during exercise. Exercise significantly increased heart rate, left ventricular systolic pressure, dP/dt, segment shortening and rate of shortening, and coronary blood flow. Both prazosin and phentolamine caused similar additional increases in dP/dt by 21 +/- 4%, in rate of shortening in the posterior region by 37 +/- 6%, and in myocardial O2 consumption by 26 +/- 11%, which were associated with a 21 +/- 3% increase in coronary flow during exercise but no change in O2 extraction. Similar results were obtained when dogs were beta-blocked with either atenolol (1.0 mg ic) or propranolol (1.0 mg ic) prior to exercise. These data suggest that an alpha 1-vasoconstriction modulates O2 delivery to myocardial tissue and limits both coronary vasodilation and cardiac function during exercise.

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