A Comparative Study of Experimental Allergic Neuritis in the Rabbit, Guinea Pig. and Mouse

1956 ◽  
Vol 15 (3) ◽  
pp. 293-334 ◽  
Author(s):  
Byron H. Waksman ◽  
Raymond D. Adams
Author(s):  
T.E. Feasby ◽  
J.J. Gilbert ◽  
A.F. Hahn ◽  
D.S. Lovgren

Abstract:Experimental allergic neuritis (EAN) in Lewis rats was treated with prednisolone given prophylactically or therapeutically. Rats treated from the time of immunization with myelin or after the establishment of clinical disease improved more rapidly than controls. Treatment at the onset of clinical signs resulted in less severe disease and more rapid recovery. Rats treated just prior to the onset of clinical signs (day 10) did not develop significant clinical disease and appeared to have less inflammation in their nerves and nerve roots on microscopic examination.


1992 ◽  
Vol 38 (3) ◽  
pp. 221-228 ◽  
Author(s):  
H. Wiethölter ◽  
M. Schabet ◽  
A. Stevens ◽  
A. Melms ◽  
N. Sommer ◽  
...  

1975 ◽  
Vol 24 (3) ◽  
pp. 365-383 ◽  
Author(s):  
J.D. Pollard ◽  
R.H.M. King ◽  
P.K. Thomas

1967 ◽  
Vol 4 (5) ◽  
pp. 464-476
Author(s):  
M. Petek ◽  
G. L. Quaglio

Experimental allergic neuritis was reproduced in chickens, by inoculation of chicken and guinea pig nerves in complete Freund's adjuvant. Paralysis was observed in a percentage of inoculated birds. Histopathologically this experimental autoimmune disease was characterized by severe demyelination of peripheral nerves in all experimental animals. In addition, oedema and/or lymphoid infiltration occurred in some of the animals. The similarity of experimental allergic neuritis to the inflammatory lesions of Marek's disease is stressed and the possible role of autoimmune processes in the pathogenesis of Marek's disease is discussed.


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