Prostaglandins Reduce the Contractile Responses to Noradrenaline and Angiotensin II in Canine Femoral Arteries After But Not Before Chronic Inhibition of Nitric Oxide Synthesis

1997 ◽  
Vol 30 (5) ◽  
pp. 690-694 ◽  
Author(s):  
Louis Puybasset ◽  
Fabrice Béverelli ◽  
Jean-François Giudicelli ◽  
Alain Berdeaux
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthesis ◽  
Contractile Responses ◽  
Femoral Arteries

Cyclosporin induces apoptosis of renal cells by enhancing nitric oxide synthesis: modulating effect of angiotensin II inhibitors

2001 ◽  
Vol 33 (1-2) ◽  
pp. 276-277 ◽  
Author(s):  
G Conti ◽  
A Amore ◽  
P Cirina ◽  
B Gianoglio ◽  
L Peruzzi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthesis ◽  
Renal Cells

Chronic inhibition of nitric oxide synthesis in rats increases aortic superoxide anion production via the action of angiotensin II

2000 ◽  
Vol 18 (12) ◽  
pp. 1795-1800 ◽  
Author(s):  
Shiro Kitamoto ◽  
Kensuke Egashira ◽  
Chu Kataoka ◽  
Makoto Usui ◽  
Masamichi Koyanagi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Superoxide Anion ◽  
Nitric Oxide Synthesis ◽  
Superoxide Anion Production ◽  
Anion Production

scholarly journals Angiotensin II and Prostaglandin Interactions on Systemic and Renal Effects of L-NAME in Humans

2001 ◽  
Vol 12 (8) ◽  
pp. 1706-1712
Author(s):  
PATRIZIA PERINOTTO ◽  
ALMERINA BIGGI ◽  
NICOLETTA CARRA ◽  
ANTONELLA ORRICO ◽  
GIUSEPPE VALMADRE ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Mean Arterial Pressure ◽  
Methyl Ester ◽  
Excretion Rate ◽  
Renal Plasma Flow ◽  
Nitric Oxide Synthesis ◽  
Renal Effects ◽  
Renal Changes ◽  
Endogenous Prostaglandins

Abstract. For investigation of whether interactions between prostaglandins and angiotensin II modulate renal response to acute nitric oxide synthesis inhibition in humans, seven young volunteers who were kept on a 240-mM Na diet underwent four experiments with 90 min of infusion of 3.0 μg/kg.min-1 NG-nitro-L-arginine methyl ester (L-NAME), each preceded by a 3-d treatment with placebo (PL), 50 mg of losartan (LOS), 75 to 125 mg of indomethacin (IND), or both drugs. Mean arterial pressure (MAP), GFR, effective renal plasma flow (ERPF), and Na excretion rate (UNaV) were measured at baseline and from 0 to 45 min and 45 to 90 min of L-NAME infusion. After PL, L-NAME reduced GFR by 5% at 45 min (P < 0.05) and by 9% at 90 min (P < 0.001), ERPF by 11 to 17% (P < 0.001), and UNaV by 28 to 45% (P < 0.001). MAP, unchanged at 45 min, rose by 5% (P < 0.001) at 90 min. LOS prevented pressor but not renal effects of L-NAME. With L-NAME+IND, MAP rose even at 45 min (+5%; P < 0.001 versus baseline) with a 10% rise at 90 min (P < 0.001). Changes in GFR (-13 to -20%), ERPF (-19 to -26%), and UNaV (-51 to -70%) were greater than those with L-NAME+PL or L-NAME+LOS (P < 0.05 to 0.001). With L-NAME+IND+LOS, MAP did not increase, and GFR, ERPF, and UNaV fell much less than with L-NAME+IND alone (P < 0.02 to 0.001) with no differences versus PL or LOS alone. Angiotensin II blockade does not affect renal changes caused by L-NAME but prevents their potentiation by prostaglandin inhibition. Thus, endogenous prostaglandins counteract renal actions of endogenous angiotensin II in Na-repleted humans even when nitric oxide synthesis is inhibited.

Angiotensin II Augments Cytokine-Stimulated Nitric Oxide Synthesis in Rat Cardiac Myocytes

Circulation ◽  
1995 ◽  
Vol 92 (9) ◽  
pp. 2683-2689 ◽  
Author(s):  
Uichi Ikeda ◽  
Yoshikazu Maeda ◽  
Yasuhiro Kawahara ◽  
Mitsuhiro Yokoyama ◽  
Kazuyuki Shimada
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Cardiac Myocytes ◽  
Nitric Oxide Synthesis ◽  
Rat Cardiac Myocytes

scholarly journals Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic Mice During Inhibition of Nitric Oxide Synthesis

Circulation ◽  
1999 ◽  
Vol 100 (18) ◽  
pp. 1901-1908 ◽  
Author(s):  
Jean-Jacques Boffa ◽  
Pierre-Louis Tharaux ◽  
Sandrine Placier ◽  
Raymond Ardaillou ◽  
Jean-Claude Dussaule ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Transgenic Mice ◽  
Collagen Type ◽  
Collagen Type I ◽  
Type I ◽  
Nitric Oxide Synthesis ◽  
Renal Vasculature ◽  
I Gene
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