Hemorrhagic Shock Treatment with Hot Intravenous Fluid in Dogs

1978 ◽  
Vol 18 (10) ◽  
pp. 726-729 ◽  
Author(s):  
DELWIN K. BUCKHOLD ◽  
W. H. PRYOR ◽  
L. D. HOMER ◽  
D. E. UDDIN ◽  
T. M. HICKEY ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Shock Treatment ◽  
Intravenous Fluid

Intracoronary naloxone in hemorrhagic shock: dose-dependent stereospecific effects

1985 ◽  
Vol 249 (2) ◽  
pp. H272-H277 ◽  
Author(s):  
R. B. Lechner ◽  
N. J. Gurll ◽  
D. G. Reynolds
Keyword(s):  
Cardiac Output ◽  
Arterial Pressure ◽  
Hemorrhagic Shock ◽  
Coronary Circulation ◽  
Opiate Receptors ◽  
Shock Treatment ◽  
Hemodynamic Effects ◽  
Pentobarbital Sodium ◽  
Shock Models ◽  
Dose Dependent

Treatment with naloxone improves cardiovascular function and survival in a variety of shock models, and numerous sites and mechanisms for its action have been proposed. Data presented in this article support the hypothesis that in hemorrhagic shock naloxone exerts its beneficial hemodynamic effects by acting primarily at cardiac opiate receptors. Naloxone or its stereoisomer (d-naloxone) were administered intravenously (iv) and directly into the coronary circulation (ic) in dogs anesthetized with pentobarbital sodium and subjected to hemorrhagic shock. Treatment with naloxone (2.0 mg/kg iv or 0.2 mg/kg ic) resulted in significant improvements in arterial pressure, myocardial contractility, and cardiac output. Treatment with saline or naloxone (0.2 mg/kg iv) were without beneficial effect. The hemodynamic responses to naloxone administered into the coronary circulation were dose dependent and stereospecific. These data support the hypothesis that naloxone exerts its salubrious effects in canine hemorrhagic shock by acting at cardiac opiate receptors.

Polydatin – a new mitochondria protector for acute severe hemorrhagic shock treatment

2012 ◽  
Vol 22 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Xingmin Wang ◽  
Rui Song ◽  
Yunyan Chen ◽  
Ming Zhao ◽  
Ke-seng Zhao
Keyword(s):  
Hemorrhagic Shock ◽  
Shock Treatment

Microcirculatory Effects of Selective Receptor Blockade During Hemorrhagic Shock Treatment With Vasopressin

Shock ◽  
2012 ◽  
Vol 38 (5) ◽  
pp. 493-498 ◽  
Author(s):  
Ronald Lima ◽  
Nivaldo R. Villela ◽  
Eliete Bouskela
Keyword(s):  
Hemorrhagic Shock ◽  
Shock Treatment ◽  
Receptor Blockade

scholarly journals Hemorrhagic shock caused by intrapleural bleeding in a draft horse – autotransfusion of the collected intrapleural blood as hemorrhagic shock treatment

2019 ◽  
Vol 35 (4) ◽  
pp. 326-335
Author(s):  
A Snyder ◽  
S Recknagel ◽  
K Ehlers ◽  
G Köller ◽  
U Siegner ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Shock Treatment

scholarly journals Comparison of the Effectiveness of Hydroxyethyl Starch (Voluven) Solution With Normal Saline in Hemorrhagic Shock Treatment in Trauma

2016 ◽  
Vol 8 (11) ◽  
pp. 815-818 ◽  
Author(s):  
Kambiz Masoumi ◽  
Arash Forouzan ◽  
Ali Asgari Darian ◽  
Alireza Rafaty Navaii
Keyword(s):  
Hemorrhagic Shock ◽  
Hydroxyethyl Starch ◽  
Normal Saline ◽  
Shock Treatment

scholarly journals Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Zhenhua Zeng ◽  
Zhongqing Chen ◽  
Siqi Xu ◽  
Rui Song ◽  
Hong Yang ◽  
...  
Keyword(s):  
Small Intestine ◽  
Hemorrhagic Shock ◽  
Survival Time ◽  
Tissue Sample ◽  
Shock Treatment ◽  
Sprague Dawley ◽  
Sample Collection ◽  
Effect Of Pd ◽  
Design And Methods ◽  
Sirt1 Activator

Objective. To evaluate the role of SIRT1 in small intestine damage following severe hemorrhagic shock and to investigate whether polydatin (PD) can activate SIRT1 in shock treatment.Research Design and Methods. The severe hemorrhagic shock model was reproduced in Sprague Dawley rats.Main Outcome Measures. Two hours after drug administration, half of the rats were assessed for survival time evaluation and the remainder were used for small intestinal tissue sample collection.Results. Bleeding and swelling appeared in the small intestine with epithelial apoptosis and gut barrier disturbance during hemorrhagic shock. SIRT1 activity and PGC-1αprotein expression of the small intestine were decreased, which led to an increase in acetylated SOD2 and decreases in the expression and activity of SOD2, resulting in severe oxidative stress. The decreased SIRT1 activity and expression were partially restored in the PD administration group, which showed reduced intestine injury and longer survival time. Notably, the effect of PD was abolished after the addition of Ex527, a selective inhibitor of SIRT1.Conclusions. The results collectively suggest a role for the SIRT1-PGC-1α-SOD2 axis in small intestine injury following severe hemorrhagic shock and that PD is an effective SIRT1 activator for the shock treatment.

GENES IN HEMORRHAGIC SHOCK: TREATMENT-TIME-ORGAN CONTINUUM

2005 ◽  
Vol 59 (2) ◽  
pp. 525 ◽  
Author(s):  
Elena Koustova ◽  
Huazhen Chen ◽  
Hasan B. Alam
Keyword(s):  
Hemorrhagic Shock ◽  
Treatment Time ◽  
Shock Treatment
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