COMPLETE CRICOTRACHEAL SEPARATION AND THIRD CERVICAL SPINAL CORD TRANSECTION FOLLOWING BLUNT NECK TRAUMA

✓ Plasma concentrations of norepinephrine (NE) were measured by a radioenzymatic assay technique before and serially after laminectomy at the C-6 level in 14 anesthetized dogs. In half the animals, no further procedures were carried out (control group); in the other dogs, cervical cord transection was performed in addition to laminectomy (experimental group). Mean plasma NE levels were similar in both groups after laminectomy and before cord interruption. In the control group, NE levels increased gradually for 2 hours after the procedure. In the group with cord transection, however, NE rose immediately after transection to 267% of the baseline value, then fell to 25% of the plasma NE level in the control group at 30 minutes, 29% at 60 minutes, and 15% at 120 minutes. Cervical spinal cord transection, therefore, results in an abrupt but short-lived increase in plasma NE concentrations. These changes in plasma NE levels may explain, at least in part, the hemodynamic alterations and the acute central hemorrhagic necrosis that occur after high spinal cord trauma.

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Long-Term Survival Following Complete Medulla/Cervical Spinal Cord Transection

Annals of Emergency Medicine ◽

10.1016/j.annemergmed.2006.08.013 ◽

2007 ◽

Vol 49 (4) ◽

pp. 540-545

Author(s):

Oliver P. Gautschi ◽

René Zellweger

Keyword(s):

Spinal Cord ◽

Cervical Spinal Cord ◽

Spinal Cord Transection ◽

Term Survival ◽

Long Term Survival

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ENHANCED PRESSOR RESPONSE TO NORADRENALINE IN PATIENTS WITH CERVICAL SPINAL CORD TRANSECTION

Brain ◽

10.1093/brain/99.4.757 ◽

1976 ◽

Vol 99 (4) ◽

pp. 757-770 ◽

Cited By ~ 72

Author(s):

C. J. MATHIAS ◽

H. L. FRANKEL ◽

N. J. CHRISTENSEN ◽

J. M. K. SPALDING

Keyword(s):

Spinal Cord ◽

Cervical Spinal Cord ◽

Pressor Response ◽

Spinal Cord Transection

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Delayed diagnosis of cervical spinal cord transection without radiographic abnormality in a 3-year-old child after a motor vehicle accident

Child s Nervous System ◽

10.1007/s00381-016-3128-9 ◽

2016 ◽

Vol 32 (8) ◽

pp. 1355-1356

Author(s):

Seunghwan Jung ◽

Sung Wook Seo ◽

Sun-Ho Lee

Keyword(s):

Spinal Cord ◽

Motor Vehicle ◽

Motor Vehicle Accident ◽

Cervical Spinal Cord ◽

Delayed Diagnosis ◽

Spinal Cord Transection ◽

Radiographic Abnormality ◽

Vehicle Accident

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Resting and stimulated endocrine function in human subjects with cervical spinal cord transection

Journal of Chronic Diseases ◽

10.1016/0021-9681(71)90110-x ◽

1971 ◽

Vol 24 (2-3) ◽

pp. 193-207 ◽

Cited By ~ 22

Author(s):

Jacqueline Claus-Walker ◽

Carlos Vallbona ◽

R.Edward Carter ◽

H.S. Lipscomb

Keyword(s):

Spinal Cord ◽

Cervical Spinal Cord ◽

Human Subjects ◽

Spinal Cord Transection ◽

Endocrine Function

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Studies of experimental cervical spinal cord transection

Journal of Neurosurgery ◽

10.3171/jns.1978.49.4.0558 ◽

1978 ◽

Vol 49 (4) ◽

pp. 558-562 ◽

Cited By ~ 30

Author(s):

Phillip A. Tibbs ◽

Byron Young ◽

R. G. McAllister ◽

William H. Brooks ◽

Laddie Tackett

Keyword(s):

Spinal Cord ◽

Arterial Pressure ◽

Systemic Vascular Resistance ◽

Vascular Resistance ◽

Cervical Spinal Cord ◽

Pressor Response ◽

Left Ventricular ◽

Spinal Cord Transection ◽

Content Type ◽

Anesthetized Dogs

✓ Two distinct and sequential patterns of hemodynamic alteration were observed after acute cervical spinal cord transection in anesthetized dogs. Interruption of the cord initially caused a 45% increase in mean arterial pressure (p < 0.01), a 34% increase in systemic vascular resistance (p < 0.05), and a 92% increase in left ventricular dp/dt (p < 0.01), reflecting a generalized sympathetic response to trauma. Concomitant bradycardia and escape arrhythmias suggested relative parasympathetic hyperactivity. Resolution of the brief pressor response was followed by a second, more prolonged, period characterized by a fall in arterial pressure to 71% of control levels (p < 0.05), a 16% decrease in systemic vascular resistance, and a 58.5% decrease in left ventricular dp/dt (p < 0.01). These latter hemodynamic changes are consistent with sympathetic denervation and failure of regulatory mechanisms mediated by both alpha- and beta-adrenergic peripheral vascular and myocardial receptors.

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