Resting and stimulated endocrine function in human subjects with cervical spinal cord transection

1971 ◽  
Vol 24 (2-3) ◽  
pp. 193-207 ◽  
Author(s):  
Jacqueline Claus-Walker ◽  
Carlos Vallbona ◽  
R.Edward Carter ◽  
H.S. Lipscomb
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Human Subjects ◽  
Spinal Cord Transection ◽  
Endocrine Function

Sensation of respiratory force following low cervical spinal cord transection

1984 ◽  
Vol 57 (4) ◽  
pp. 989-994 ◽  
Author(s):  
S. B. Gottfried ◽  
I. Leech ◽  
A. F. DiMarco ◽  
W. Zaccardelli ◽  
M. D. Altose
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Spinal Cord Transection

Studies of experimental cervical spinal cord transection

1979 ◽  
Vol 50 (5) ◽  
pp. 629-632 ◽  
Author(s):  
Phillip A. Tibbs ◽  
Byron Young ◽  
Michael G. Ziegler ◽  
R. G. McAllister
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Plasma Concentrations ◽  
Spinal Cord Transection ◽  
Cervical Cord ◽  
Control Group ◽  
Content Type ◽  
Hemorrhagic Necrosis ◽  
Anesthetized Dogs ◽  
Experimental Group

✓ Plasma concentrations of norepinephrine (NE) were measured by a radioenzymatic assay technique before and serially after laminectomy at the C-6 level in 14 anesthetized dogs. In half the animals, no further procedures were carried out (control group); in the other dogs, cervical cord transection was performed in addition to laminectomy (experimental group). Mean plasma NE levels were similar in both groups after laminectomy and before cord interruption. In the control group, NE levels increased gradually for 2 hours after the procedure. In the group with cord transection, however, NE rose immediately after transection to 267% of the baseline value, then fell to 25% of the plasma NE level in the control group at 30 minutes, 29% at 60 minutes, and 15% at 120 minutes. Cervical spinal cord transection, therefore, results in an abrupt but short-lived increase in plasma NE concentrations. These changes in plasma NE levels may explain, at least in part, the hemodynamic alterations and the acute central hemorrhagic necrosis that occur after high spinal cord trauma.

scholarly journals Longitudinal changes in DTI parameters of specific spinal white matter tracts correlate with behavior following spinal cord injury in monkeys

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Arabinda Mishra ◽  
Feng Wang ◽  
Li Min Chen ◽  
John C. Gore
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Spinal Cord Injuries ◽  
Diffusion Tensor ◽  
Cervical Spinal Cord ◽  
Human Subjects ◽  
Realistic Model ◽  
White Matter Tracts ◽  
Injured Side ◽  
Cord Injury

Abstract This study aims to evaluate how parameters derived from diffusion tensor imaging reflect axonal disruption and demyelination in specific white matter tracts within the spinal cord of squirrel monkeys following traumatic injuries, and their relationships to function and behavior. After a unilateral section of the dorsal white matter tract of the cervical spinal cord, we found that both lesioned dorsal and intact lateral tracts on the lesion side exhibited prominent disruptions in fiber orientation, integrity and myelination. The degrees of pathological changes were significantly more severe in segments below the lesion than above. The lateral tract on the opposite (non-injured) side was minimally affected by the injury. Over time, RD, FA, and AD values of the dorsal and lateral tracts on the injured side closely tracked measurements of the behavioral recovery. This unilateral section of the dorsal spinal tract provides a realistic model in which axonal disruption and demyelination occur together in the cord. Our data show that specific tract and segmental FA and RD values are sensitive to the effects of injury and reflect specific behavioral changes, indicating their potential as relevant indicators of recovery or for assessing treatment outcomes. These observations have translational value for guiding future studies of human subjects with spinal cord injuries.

ENHANCED PRESSOR RESPONSE TO NORADRENALINE IN PATIENTS WITH CERVICAL SPINAL CORD TRANSECTION

Brain ◽  
1976 ◽  
Vol 99 (4) ◽  
pp. 757-770 ◽  
Author(s):  
C. J. MATHIAS ◽  
H. L. FRANKEL ◽  
N. J. CHRISTENSEN ◽  
J. M. K. SPALDING
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Pressor Response ◽  
Spinal Cord Transection

Studies of experimental cervical spinal cord transection

1978 ◽  
Vol 49 (4) ◽  
pp. 558-562 ◽  
Author(s):  
Phillip A. Tibbs ◽  
Byron Young ◽  
R. G. McAllister ◽  
William H. Brooks ◽  
Laddie Tackett
Keyword(s):  
Spinal Cord ◽  
Arterial Pressure ◽  
Systemic Vascular Resistance ◽  
Vascular Resistance ◽  
Cervical Spinal Cord ◽  
Pressor Response ◽  
Left Ventricular ◽  
Spinal Cord Transection ◽  
Content Type ◽  
Anesthetized Dogs

✓ Two distinct and sequential patterns of hemodynamic alteration were observed after acute cervical spinal cord transection in anesthetized dogs. Interruption of the cord initially caused a 45% increase in mean arterial pressure (p < 0.01), a 34% increase in systemic vascular resistance (p < 0.05), and a 92% increase in left ventricular dp/dt (p < 0.01), reflecting a generalized sympathetic response to trauma. Concomitant bradycardia and escape arrhythmias suggested relative parasympathetic hyperactivity. Resolution of the brief pressor response was followed by a second, more prolonged, period characterized by a fall in arterial pressure to 71% of control levels (p < 0.05), a 16% decrease in systemic vascular resistance, and a 58.5% decrease in left ventricular dp/dt (p < 0.01). These latter hemodynamic changes are consistent with sympathetic denervation and failure of regulatory mechanisms mediated by both alpha- and beta-adrenergic peripheral vascular and myocardial receptors.

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