The Influence of Ejaculation on Serum Levels of Prostate Specific Antigen

Objective: To describe the reference ranges of serum prostate-specific antigen (PSA) in Saudi men. Materials/Subjects and Methods: Saudi males, aged 30 and above, were invited to participate in the study. Blood samples were taken from each subject to determine serum levels of PSA. Blood sugar levels, lipid profile, and anthropometric measurements were also obtained. Results: Our cohort consisted of 7,814 men; their mean PSA level was 1.24 ng/mL. The majority (90.5%) had PSA values between 0 and 2.5 ng/mL. The median PSA and the 95th percentile increased steadily with age. There was a sharp increase in the 95th percentile, from 3.8 ng/mL in men between 60 and 70 years old to 6.9 ng/mL in men over 71 years old. The 95th percentiles of PSA serum levels were lower in Saudi men than in the general population. Conclusions: PSA serum levels in Saudi men are lower than in other communities. Creating age-specific reference ranges could improve the sensitivity of the PSA tests by allowing the detection of treatable tumors in younger men if the threshold of 4.0 ng/mL is lowered. Furthermore, unnecessary biopsies among older men may be avoided if the threshold is increased.

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Are Total Prostate-specific Antigen Serum Levels in Cirrhotic Men Different From Those in Normal Men?

Urology ◽

10.1016/j.urology.2009.01.015 ◽

2009 ◽

Vol 73 (5) ◽

pp. 1032-1035 ◽

Cited By ~ 11

Author(s):

Fabio C. Vicentini ◽

Luiz A.A. Botelho ◽

Marcelo Hisano ◽

Gustavo X. Ebaid ◽

Marcos Lucon ◽

...

Keyword(s):

Prostate Specific Antigen ◽

Specific Antigen ◽

Serum Levels ◽

Total Prostate Specific Antigen ◽

Normal Men

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The Practicality of Targeted Prostate Biopsy Procedures on the Dominant Side of the Tumor Determined by Magnetic Resonance Imaging in Elderly Patients with High Serum Levels of Prostate-Specific Antigen

The World Journal of Men s Health ◽

10.5534/wjmh.2015.33.3.188 ◽

2015 ◽

Vol 33 (3) ◽

pp. 188

Author(s):

Jung Sik Huh ◽

Bong Soo Kim ◽

Young Joo Kim ◽

Sung Dae Kim ◽

Kyung Kgi Park

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Elderly Patients ◽

Prostate Specific Antigen ◽

Prostate Biopsy ◽

Specific Antigen ◽

Serum Levels ◽

High Serum ◽

Resonance Imaging ◽

Dominant Side

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Serum levels of prostate-specific antigen in normal boys throughout puberty

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.78.5.1185 ◽

1994 ◽

Vol 78 (5) ◽

pp. 1185-1187 ◽

Cited By ~ 14

Author(s):

J. G. Vieira

Keyword(s):

Prostate Specific Antigen ◽

Specific Antigen ◽

Serum Levels

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Prostate-Specific Antigen Increase during Dutasteride to Indicate the Need for Prostate Biopsy: Influence of Prostatic Inflammation

Urologia Journal ◽

10.5301/uj.5000227 ◽

2017 ◽

Vol 84 (3) ◽

pp. 158-164 ◽

Cited By ~ 1

Author(s):

Alessandro Sciarra ◽

Martina Maggi ◽

Andrea Fasulo ◽

Stefano Salciccia ◽

Vincenzo Gentile ◽

...

Keyword(s):

Prostate Specific Antigen ◽

Prostate Biopsy ◽

Specific Antigen ◽

Serum Levels ◽

Prostate Biopsies ◽

Total Prostate Specific Antigen ◽

Group A ◽

Inflammatory Infiltrates ◽

Prostatic Inflammation

Introduction The aim of this study was to analyze the significance of an increase in total prostate-specific antigen (PSA) serum levels despite dutasteride treatment as a predictor of prostate cancer (PC) at biopsy. We focused our attention on the rate of the first PSA increase and on the influence of prostatic inflammation. Methods From 2011 to 2016, 365 men with a previous negative prostate biopsy and persistent elevated PSA levels received dutasteride treatment. The population was followed for a range of 12-48 months. Results One hundred twelve cases with a confirmed PSA increase >0.5 ng/ml over the nadir value during the follow-up were included in Group A and underwent a new prostate biopsy. In Group A, the PSA increase was associated with PC at the re-biopsy in 66% of cases. The percentage of PSA reduction after 6 months of treatment was not a significant indicator of the risk for PC. The distribution of inflammatory infiltrates significantly (p<00.01) varied from positive to negative prostate biopsies. The relative risk for PC at biopsy significantly increased according to PSA level during dutasteride. Conclusions Treatment with dutasteride can help to analyze PSA kinetic. A persistent prostatic inflammation is a factor able to reduce the performance of PSA kinetic during dutasteride treatment.

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Serum Levels of Prostate-Specific Antigen Among Japanese-American and Native Japanese Men

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/89.22.1716 ◽

1997 ◽

Vol 89 (22) ◽

pp. 1716-1720 ◽

Cited By ~ 27

Author(s):

A. Shibata ◽

A. S. Whittemore ◽

R. S. Paffenbarger ◽

K. Imai ◽

L. N. Kolonel ◽

...

Keyword(s):

Prostate Specific Antigen ◽

Specific Antigen ◽

Serum Levels ◽

Japanese American ◽

Japanese Men

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The Influence of Ejaculation on Serum Levels of Prostate Specific Antigen

The Journal of Urology ◽

10.1016/s0022-5347(01)65327-8 ◽

1997 ◽

Vol 157 (1) ◽

pp. 209-211 ◽

Cited By ~ 26

Author(s):

Axel Heidenreich ◽

Roland Vorreuther ◽

Stefan Neubauer ◽

Jens Westphal ◽

Udo H. Engelmann ◽

...

Keyword(s):

Prostate Specific Antigen ◽

Specific Antigen ◽

Serum Levels

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The Effect of Prostate Aspiration Biopsy on Serum Levels of Prostatic Acid Phosphatase and Prostate-Specific Antigen

JAMA ◽

10.1001/jama.1986.03380040048026 ◽

1986 ◽

Vol 256 (4) ◽

pp. 474 ◽

Cited By ~ 4

Author(s):

Anne Charrie

Keyword(s):

Acid Phosphatase ◽

Prostate Specific Antigen ◽

Specific Antigen ◽

Prostatic Acid Phosphatase ◽

Serum Levels ◽

Aspiration Biopsy

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Long-distance mountain biking does not disturb the measurement of total, free or complexed prostate-specific antigen in healthy men

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2004.061 ◽

2004 ◽

Vol 42 (3) ◽

Cited By ~ 12

Author(s):

Markus Herrmann ◽

Jürgen Scharhag ◽

Marga Sand-Hill ◽

Wilfried Kindermann ◽

Wolfgang Herrmann

Keyword(s):

Prostate Specific Antigen ◽

Endurance Exercise ◽

Specific Antigen ◽

Serum Levels ◽

Normal Serum ◽

Mountain Biking ◽

Mountain Bike ◽

Long Distance ◽

Healthy Men ◽

Before And After

AbstractPurpose: Mechanical manipulation of the prostate is a generally accepted interfering factor for the measurement of prostate-specific antigen (PSA). However, only few studies have focused on common daily mechanical manipulations, such as bicycle riding. Furthermore, physical exercise is also supposed to modulate PSA serum concentration. Long-distance mountain biking is an excellent model to study the combined effect of mechanical prostate manipulation by bicycle riding and strenuous endurance exercise on total, free and complexed PSA (tPSA, fPSA, cPSA). Materials and methods: We investigated tPSA, fPSA and cPSA in 42 healthy male cyclists (mean age 35±6 years) before and after a 120 km off-road mountain bike race. Blood sampling was done before, 15 min and 3 h after the race. Results: Mean race time was 342±65 min. All athletes had normal serum levels of tPSA, fPSA or cPSA. None of these parameters was modified by the race. Conclusions: In healthy men the measurement of tPSA, fPSA and cPSA is not disturbed by preceding long distance mountain biking or endurance exercise. Based on the present data, there is no evidence for a recommendation to limit bicycle riding or physical activity before the measurement of tPSA, fPSA or cPSA.

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