Single Dose Imipramine Reduces Nocturnal Urine Output in Patients With Nocturnal Enuresis and Nocturnal Polyuria

1997 ◽  
pp. 830-836 ◽  
Author(s):  
J. M. Hunsballe ◽  
S. Rittig ◽  
E. B. Pedersen ◽  
O. V. Olesen ◽  
J. C. Djurhuus
Keyword(s):  
Single Dose ◽  
Urine Output ◽  
Nocturnal Enuresis ◽  
Nocturnal Polyuria

Single Dose Imipramine Reduces Nocturnal Urine Output in Patients With Nocturnal Enuresis and Nocturnal Polyuria

1997 ◽  
Vol 158 (3) ◽  
pp. 830-836 ◽  
Author(s):  
J.M. Hunsballe ◽  
S. Rittig ◽  
E.B. Pedersen ◽  
O.V. Olesen ◽  
J.C. Djurhuus
Keyword(s):  
Single Dose ◽  
Urine Output ◽  
Nocturnal Enuresis ◽  
Nocturnal Polyuria

Evaluating nocturnal polyuria in Japanese children with nocturnal enuresis

2021 ◽  
Author(s):  
Naoto Nishizaki ◽  
Taichi Hara ◽  
Kaoru Obinata ◽  
Toshiaki Shimizu
Keyword(s):  
Nocturnal Enuresis ◽  
Nocturnal Polyuria ◽  
Japanese Children

scholarly journals Urinary Aquaporin 2 and Calciuria Correlate with the Severity of Enuresis in Children

2000 ◽  
Vol 11 (10) ◽  
pp. 1873-1881
Author(s):  
GIOVANNA VALENTI ◽  
ANTONIA LAERA ◽  
GIUSEPPE PACE ◽  
GABRIELLA ACETO ◽  
MARIA L. LOSPALLUTI ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Urine Sample ◽  
Western Blotting ◽  
Nocturnal Enuresis ◽  
Urine Samples ◽  
Healthy Children ◽  
Nocturnal Polyuria ◽  
Aquaporin 2 ◽  
Threefold Increase ◽  
Absorptive Hypercalciuria

Abstract. This study examined the hypothesis that nocturnal enuresis might be paralleled by aquaporin 2 (AQP2) urinary excretion. Eighty children who experienced nocturnal enuresis were studied and compared with 9 healthy children. The 24-h urine samples were divided into two portions: night collections and day collections. Creatinine equivalents of urine samples from each patient were analyzed by Western blotting. AQP2 levels were semiquantified by densitometric scanning and reported as a ratio between the intensity of the signal in the day urine sample versus the night urine sample (D/N AQP2 ratio). The D/N AQP2 ratio was 0.59 ± 0.11 (n = 9) in healthy children and increased to 1.27 ± 0.24 (n = 10) in a subpopulation of enuretic children who had low nocturnal vasopressin levels. In enuretic children who displayed hypercalciuria and had normal vasopressin levels, the D/N AQP2 ratio was 1.05 ± 0.27 (n = 8). These data indicate that reduced secretion of vasopressin and absorptive hypercalciuria are independently associated with an approximately twofold increase in the urinary D/N AQP2 ratio. When low nocturnal vasopressin levels were associated with hypercalciuria, a nearly threefold increase in the D/N AQP2 ratio was observed (1.67 ± 0.41, n = 11). In addition, in all enuretic patients tested, the urinary D/N AQP2 ratio correlates perfectly with the severity of the disorder (nocturnal polyuria). The findings reported in this article indicate that urinary AQP2 correlates with the severity of enuresis in children.

scholarly journals Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient

2018 ◽  
Vol 90 (2) ◽  
pp. 127 ◽  
Author(s):  
Pietro Ferrara ◽  
Ester Del Vescovo ◽  
Francesca Ianniello ◽  
Giulia Franceschini ◽  
Luciana Romaniello ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Nocturnal Enuresis ◽  
Bladder Function ◽  
Efficacy And Safety ◽  
Nocturnal Polyuria ◽  
First Line ◽  
Normal Bladder ◽  
Increased Risk ◽  
The Right ◽  
Line Drug

Background: The first-line drug therapy for patients with nocturnal enuresis (NE) associated with nocturnal polyuria and normal bladder function is desmopressin (dDAVP). Objective: To evaluate if increasing dose of oral desmopressin lyophilisate (MELT) can improve response rates to dDAVP and is useful in enuretic children. Materials and methods: We enrolled a total of 260 children all diagnosed with NE. Enuretic children were treated with increasing MELT at a dose of 120, 180 and 240 mcg a day.Results. We included in our study a total of 237 children, 164 males (69.2%) and 73 females (30.8%) aged between 5 and 18 years (mean age 10.32 ± 2.52 years). Of the 237 patients enrolled in the study and treated with MELT 120 mcg, a full response was achieved in 135 (56.9%). A partial response was achieved in 21 (8.9%) patients, therefore the dose was increased up to 180 mcg, with further improving symptoms (14.3%) or full response (9.5%), and up to 240 mcg, without usefulness. Conclusions: MELT at the dose of 120 mcg resulted efficacy and safety; the increased dose up to 180 mcg resulted poorly efficacy; finally, the further increase up to 240 mcg did not improve the symptoms with the increased risk of side effects.

SODIUM FRACTION EXCRETION RATE IN NOCTURNAL ENURESIS CORRELATES WITH NOCTURNAL POLYURIA AND OSMOLALITY

2004 ◽  
Vol 171 (6 Part 2) ◽  
pp. 2567-2570 ◽  
Author(s):  
GABRIELLA ACETO ◽  
ROSA PENZA ◽  
MAURIZIO DELVECCHIO ◽  
MARIA LAURA CHIOZZA ◽  
MARCELLO CIMADOR ◽  
...  
Keyword(s):  
Nocturnal Enuresis ◽  
Excretion Rate ◽  
Nocturnal Polyuria

Desmopressin response in nocturnal enuresis without nocturnal polyuria in Japanese children

2021 ◽  
Author(s):  
Shohei Akagawa ◽  
Shoji Tsuji ◽  
Yuko Akagawa ◽  
Sohsaku Yamanouchi ◽  
Takahisa Kimata ◽  
...  
Keyword(s):  
Nocturnal Enuresis ◽  
Nocturnal Polyuria ◽  
Japanese Children

Nocturnal polyuria in monosymptomatic nocturnal enuresis refractory to desmopressin treatment

2006 ◽  
Vol 291 (6) ◽  
pp. F1232-F1240 ◽  
Author(s):  
K. Kamperis ◽  
S. Rittig ◽  
K. A. Jørgensen ◽  
J. C. Djurhuus
Keyword(s):  
Nocturnal Enuresis ◽  
Sodium Intake ◽  
Blood Pressure Monitoring ◽  
Free Water ◽  
Prostaglandin E ◽  
Inadequate Response ◽  
Nocturnal Polyuria ◽  
Urine Production ◽  
Monosymptomatic Nocturnal Enuresis ◽  
Do So

The transition from day to night is associated with a pronounced decline in diuresis with reductions in the amount of excreted water, electrolytes, and other end products of our metabolism. Failure to do so leads to a large urine output at night, a condition known as nocturnal polyuria, encountered in a large proportion of children with nocturnal enuresis. The aim of this study was to clarify the mechanisms responsible for the nocturnal polyuria seen in enuretics with inadequate response to desmopressin (dDAVP). Forty-six enuretics (7–14 yr of age) and fifteen age-matched controls were admitted for a 24-h protocol with standardized fluid and sodium intake, comprising urine collections, blood sampling, and blood pressure monitoring. We included patients with severe enuresis (5 ± 1 wet nights/wk) showing <50% reduction in wet nights on dDAVP. We characterized the patients on the basis of their nocturnal urine production. The children with nocturnal polyuria excreted larger amounts of sodium and urea at night than nonpolyurics and controls. Solute-free water reabsorption as well as urinary arginine vasopressin and aquaporin-2 excretion were normal in polyurics, and no differences were found in atrial natriuretic peptide, angiotensin II, aldosterone, and renin levels. Urinary prostaglandin E2 (PGE2) excretion was significantly higher in polyurics. The nocturnal polyuria in children with dDAVP-resistant nocturnal enuresis seems to be the result of augmented sodium and urea excretion. The high urinary PGE2 levels found in these children point toward a role for increased prostaglandin synthesis in the pathogenesis of enuresis-related polyuria.

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