REGULATION OF KERATINOCYTE GROWTH FACTOR RECEPTOR AND ANDROGEN RECEPTOR IN EPITHELIAL CELLS OF THE HUMAN PROSTATE

2001 ◽  
pp. 678-683 ◽  
Author(s):  
BERNHARD PLANZ ◽  
QIFA WANG ◽  
SANDRA D. KIRLEY ◽  
MICHAEL MARBERGER ◽  
W. SCOTT MCDOUGAL
Keyword(s):  
Androgen Receptor ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Keratinocyte Growth Factor ◽  
Growth Factor Receptor ◽  
Human Prostate

REGULATION OF KERATINOCYTE GROWTH FACTOR RECEPTOR AND ANDROGEN RECEPTOR IN EPITHELIAL CELLS OF THE HUMAN PROSTATE

1999 ◽  
pp. 230
Author(s):  
Bernhard Planz ◽  
Bob Djavan ◽  
Michael Marberger ◽  
QiFa Wang ◽  
Sandra D. Kirley ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Keratinocyte Growth Factor ◽  
Growth Factor Receptor ◽  
Human Prostate

REGULATION OF KERATINOCYTE GROWTH FACTOR RECEPTOR AND ANDROGEN RECEPTOR IN EPITHELIAL CELLS OF THE HUMAN PROSTATE

2001 ◽  
Vol 166 (2) ◽  
pp. 678-683 ◽  
Author(s):  
BERNHARD PLANZ ◽  
QIFA WANG ◽  
SANDRA D. KIRLEY ◽  
MICHAEL MARBERGER ◽  
W. SCOTT MCDOUGAL
Keyword(s):  
Androgen Receptor ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Keratinocyte Growth Factor ◽  
Growth Factor Receptor ◽  
Human Prostate

Type-1 insulin-like growth factor receptor reexpression in the malignant phenotype of SV40-T-immortalized human prostate epithelial cells enhances apoptosis

Endocrine ◽  
1997 ◽  
Vol 7 (1) ◽  
pp. 119-124 ◽  
Author(s):  
S Stephen R. Plymate ◽  
Victoria L. Bae ◽  
Lisette Maddison ◽  
LeBris S. Quinn ◽  
Joy L. Ware
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Growth Factor Receptor ◽  
Human Prostate ◽  
Insulin Like Growth Factor ◽  
Malignant Phenotype ◽  
Prostate Epithelial Cells

scholarly journals Ribosomal S6 Kinase as a Mediator of Keratinocyte Growth Factor-induced Activation of Akt in Epithelial Cells

2004 ◽  
Vol 15 (7) ◽  
pp. 3106-3113 ◽  
Author(s):  
Zhong-Zong Pan ◽  
Yvan Devaux ◽  
Prabir Ray
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Keratinocyte Growth Factor ◽  
Growth Factor Receptor ◽  
Protective Effects ◽  
S6 Kinase ◽  
Akt Activation ◽  
Ribosomal S6 Kinase

The keratinocyte growth factor receptor (KGFR) is a member of the fibroblast growth factor receptor (FGFR) superfamily. The proximal signaling molecules of FGFRs are much less characterized compared with other growth factor receptors. Using the yeast two-hybrid assay, we have identified ribosomal S6 kinase (RSK) to be a protein that associates with the cytoplasmic domain of the KGFR. The RSK family of kinases controls multiple cellular processes, and our studies for the first time show association between the KGFR and RSK. Using a lung-specific inducible transgenic system we have recently demonstrated protective effects of KGF on the lung epithelium and have demonstrated KGF-induced activation of the prosurvival Akt pathway both in vivo and in vitro. Here we show that a kinase inactive RSK mutant blocks KGF-induced Akt activation and KGF-mediated inhibition of caspase 3 activation in epithelial cells subjected to oxidative stress. It was recently shown that RSK2 recruits PDK1, the kinase responsible for both Akt and RSK activation. When viewed collectively, it appears that the association between the KGFR and RSK plays an important role in KGF-induced Akt activation and consequently in the protective effects of KGF on epithelial cells.

Keratinocyte Growth Factor Receptor is Up-regulated in Cyclosporin A-induced Gingival Hyperplasia

2002 ◽  
Vol 81 (10) ◽  
pp. 683-687 ◽  
Author(s):  
S.J. Das ◽  
H.N. Newman ◽  
I. Olsen
Keyword(s):  
Polymerase Chain Reaction ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Cyclosporin A ◽  
Keratinocyte Growth Factor ◽  
Growth Factor Receptor ◽  
Gene Transcript ◽  
Gingival Hyperplasia ◽  
Chain Reaction ◽  
Polymerase Chain

Keratinocyte growth factor stimulates the growth and activity of epithelial cells via the keratinocyte growth factor receptor. We have recently shown that the growth factor is markedly elevated in cyclosporin A-induced gingival hyperplasia tissue in vivo, but the effects of cyclosporin A on the receptor are not yet known. The present study was therefore carried out to determine whether expression of the keratinocyte growth factor receptor is up-regulated in gingival hyperplasia compared with normal gingiva. Using immunohistochemistry and the reverse-transcribed polymerase chain-reaction, we obtained results which showed that receptor antigen and gene transcript levels were both elevated in gingival hyperplasia tissue. In addition, flow cytometry and the reverse-transcribed polymerase chain-reaction showed that the receptor and mRNA were also higher in gingival epithelial cells following incubation with cyclosporin A in vitro. These findings suggest that the keratinocyte growth factor-receptor pathway of mesenchymal-epithelial interaction could play an important part in the molecular pathogenesis of gingival hyperplasia.

Aberrant expression of keratinocyte growth factor receptor in ovarian surface epithelial cells of endometrioma

2008 ◽  
Vol 89 (2) ◽  
pp. 478-480 ◽  
Author(s):  
Fuminori Taniguchi ◽  
Tasuku Harada ◽  
Tomio Iwabe ◽  
Yoko Ohama ◽  
Yasuko Takenaka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Keratinocyte Growth Factor ◽  
Growth Factor Receptor ◽  
Aberrant Expression ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

Immunolocalization of the keratinocyte growth factor in benign and neoplastic human prostate and its relation to androgen receptor

The Prostate ◽  
1999 ◽  
Vol 41 (4) ◽  
pp. 233-242 ◽  
Author(s):  
Bernhard Planz ◽  
H. Thomas Aretz ◽  
QiFa Wang ◽  
Shahin Tabatabaei ◽  
Sandra D. Kirley ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Growth Factor ◽  
Keratinocyte Growth Factor ◽  
Human Prostate
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