THE EFFECT OF INSULIN INJECTION SITE SELECTION ON POST-EXERCISE BLOOD GLUCOSE RESPONSES OF DIABETIC CHILDREN 230

Objective: Evaluation the hypoglycemic effect of Gydenphy capsules on Streptozotocin-induced type 1 diabetic in Swiss mouse model. Methods: The type 1 diabetic model was established by intraperitoneal injections of Streptozocin 150mg/kg in Swiss mouse. Then, the Gydenphy were orally administered daily at a dose of 576 mg/kg/day or 1152 mg/kg/day in 10 days. Blood glucose concentration in the Gydenphy oral groups with that of water control group and the intraperitoneal insulin injection group was compared. Results: Blood glucose concentration in the groups using Gydenphy (dose576 mg/kg/24h and dose 1152 mg/kg/24h) significal decreased compared to the distilled water group at (p <0.05 at the time of 4 hours, 8 hours; p <0.01 at the time of 3, 10 days). The hypoglycemic effect of Gydenphy at 576mg/kg/day and 1152 mg/kg/day at 4 hours, 8 hours and 3 days were inferior to insulin 0.1 UI/kg/day for glycemic control. However, the hypoglycemic effect ofGydenphy were equivalent to insulin after 10 consecutive days on treatment. Conclusion: Gydenphy capsules have hypoglycemic effects onStreptozotocin-induced type 1 diabetes in Swiss mouse model.

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The B2 Receptor of Bradykinin Is Not Essential for the Post-Exercise Increase in Glucose Uptake by Insulin-Stimulated Mouse Skeletal Muscle

Physiological Research ◽

10.33549/physiolres.932085 ◽

2011 ◽

pp. 511-519 ◽

Cited By ~ 7

Author(s):

G. G. SCHWEITZER ◽

C. M. CASTORENA ◽

T. HAMADA ◽

K. FUNAI ◽

E. B. ARIAS ◽

...

Keyword(s):

Skeletal Muscle ◽

Blood Glucose ◽

Glucose Uptake ◽

Insulin Action ◽

Plasma Insulin ◽

Treadmill Exercise ◽

Post Exercise ◽

Skeletal Muscle Glucose Uptake ◽

Glucose Plasma ◽

Exercise Induced

Bradykinin can enhance skeletal muscle glucose uptake (GU), and exercise increases both bradykinin production and muscle insulin sensitivity, but bradykinin’s relationship with post-exercise insulin action is uncertain. Our primary aim was to determine if the B2 receptor of bradykinin (B2R) is essential for the post-exercise increase in GU by insulin-stimulated mouse soleus muscles. Wildtype (WT) and B2R knockout (B2RKO) mice were sedentary or performed 60 minutes of treadmill exercise. Isolated soleus muscles were incubated with [3H]-2-deoxyglucose ±insulin (60 or 100 μU/ml). GU tended to be greater for WT vs. B2RKO soleus with 60 μU/ml insulin (P=0.166) and was significantly greater for muscles with 100 μU/ml insulin (P<0.05). Both genotypes had significant exercise-induced reductions (P<0.05) in glycemia and insulinemia, and the decrements for glucose (~14 %) and insulin (~55 %) were similar between genotypes. GU tended to be greater for exercised vs. sedentary soleus with 60 μU/ml insulin (P=0.063) and was significantly greater for muscles with 100 μU/ml insulin (P<0.05). There were no significant interactions between genotype and exercise for blood glucose, plasma insulin or GU. These results indicate that the B2R is not essential for the exercise-induced decrements in blood glucose or plasma insulin or for the post-exercise increase in GU by insulin-stimulated mouse soleus muscle.

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Effects of Post-Exercise Honey Drink Ingestion on Blood Glucose and Subsequent Running Performance in the Heat

Asian Journal of Sports Medicine ◽

10.5812/asjsm.24044 ◽

2015 ◽

Vol 6 (3) ◽

Cited By ~ 6

Author(s):

Nur Syamsina Ahmad ◽

Foong Kiew Ooi ◽

Mohammed Saat Ismail ◽

Mahaneem Mohamed

Keyword(s):

Blood Glucose ◽

Post Exercise ◽

Running Performance

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Cutaneous amyloidosis at insulin injection site

Reactions Weekly ◽

10.1007/s40278-020-84241-1 ◽

2020 ◽

Vol 1825 (1) ◽

pp. 1-1

Keyword(s):

Injection Site ◽

Insulin Injection

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Effect of Exercise Duration on Postprandial Glycaemic and Insulinaemic Responses in Adolescents

Nutrients ◽

10.3390/nu12030754 ◽

2020 ◽

Vol 12 (3) ◽

pp. 754

Author(s):

Karah J. Dring ◽

Simon B. Cooper ◽

Ryan A. Williams ◽

John G. Morris ◽

Caroline Sunderland ◽

...

Keyword(s):

Blood Glucose ◽

Plasma Insulin ◽

Intermittent Exercise ◽

Blood Glucose Concentration ◽

Area Under The Curve ◽

Exercise Duration ◽

Plasma Insulin Concentration ◽

Post Exercise ◽

Beneficial Effects ◽

Loughborough Intermittent Shuttle Test

High-intensity intermittent exercise (HIIE) is a potential intervention to manage hyperglycaemia and insulin resistance in adolescents. The aim of this study was to determine the optimum duration of HIIE to reduce postprandial glycaemic and insulinaemic responses in adolescents and the longevity of the response. Thirty-nine participants (12.4 ± 0.4 year) completed a 30- and 60-min exercise trial (Loughborough Intermittent Shuttle Test) and a rested control trial in a randomised crossover design. Capillary blood samples were taken at baseline, immediately and 1-h post-exercise; and 30, 60 and 120 min following a standardised lunch (day one) and a standardised breakfast 24-h post-exercise. Plasma insulin total area under the curve (tAUC) following lunch was lower following 60-min HIIE (21,754 ± 16,861 pmol·L−1 × 120 min, p = 0.032) and tended to be lower following 30-min HIIE (24,273 ± 16,131 pmol·L−1 × 120 min, p = 0.080), when compared with the resting condition (26,931 ± 21,634 pmol·L−1 × 120 min). Blood glucose concentration was lower 1-h post-exercise following 30-min HIIE (3.6 ± 0.6 mmol·L−1) when compared to resting (4.1 ± 0.9 mmol·L−1, p = 0.001). Blood glucose and plasma insulin concentration did not differ across trials on day two. Shorter bouts of HIIE (30-min), as well as a 60-min bout, reduced the postprandial insulinaemic response to lunch, an ecologically valid marker of insulin sensitivity. As the beneficial effects of HIIE were limited to 3 h post-exercise, adolescents are recommended to engage daily HIIE to enhance metabolic health.

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