REDUCED MYOSIN HEAVY CHAIN I IN SKELETAL MUSCLE IN CHRONIC HEART FAILURE: RELATIONSHIP TO NEUROHUMORAL FACTORS 1506

1997 ◽  
Vol 29 (Supplement) ◽  
pp. 264
Author(s):  
B D Duscha ◽  
M J Sullivan ◽  
F Schachat ◽  
C Kuhn ◽  
J Blank ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Chronic Heart Failure ◽  
Myosin Heavy Chain ◽  
Heavy Chain

Altered expression of myosin heavy chain in human skeletal muscle in chronic heart failure

1997 ◽  
Vol 29 (7) ◽  
pp. 860-866 ◽  
Author(s):  
MARTIN J. SULLIVAN ◽  
BRIAN D. DUSCHA ◽  
HENRIK KLITGAARD ◽  
WILLIAM E. KRAUS ◽  
FREDERICK R. COBB ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Chronic Heart Failure ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Human Skeletal Muscle ◽  
Altered Expression

Changes in skeletal muscle myosin heavy chain isoform content during congestive heart failure

2002 ◽  
Vol 87 (2) ◽  
pp. 182-186 ◽  
Author(s):  
Espen Spangenburg ◽  
Robert Talmadge ◽  
Timothy Musch ◽  
Pfeifer P. ◽  
Richard McAllister ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Congestive Heart Failure ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Skeletal Muscle Myosin ◽  
Myosin Heavy Chain Isoform ◽  
Muscle Myosin

scholarly journals Myosin heavy chain expression and atrophy in rat skeletal muscle during transition from cardiac hypertrophy to heart failure

2003 ◽  
Vol 84 (4) ◽  
pp. 201-206 ◽  
Author(s):  
Robson Francisco Carvalho ◽  
Antonio Carlos Cicogna ◽  
Gerson Eduardo Rocha Campos ◽  
Jeane Marlene FogaÇa De Assis ◽  
Carlos Roberto Padovani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Cardiac Hypertrophy ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Rat Skeletal Muscle

scholarly journals The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression

2004 ◽  
Vol 24 (19) ◽  
pp. 8705-8715 ◽  
Author(s):  
Carmen C. Sucharov ◽  
Steve M. Helmke ◽  
Stephen J. Langer ◽  
M. Benjamin Perryman ◽  
Michael Bristow ◽  
...  
Keyword(s):  
Heart Failure ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Human Heart ◽  
Ventricular Myocytes ◽  
Major Effect ◽  
Neonatal Rat ◽  
Chain Gene ◽  
Human Heart Failure ◽  
Peptide Mass

ABSTRACT Human heart failure is accompanied by repression of genes such as α myosin heavy chain (αMyHC) and SERCA2A and the induction of fetal genes such as βMyHC and atrial natriuretic factor. It seems likely that changes in MyHC isoforms contribute to the poor contractility seen in heart failure, because small changes in isoform composition can have a major effect on the contractility of cardiac myocytes and the heart. Our laboratory has recently shown that YY1 protein levels are increased in human heart failure and that YY1 represses the activity of the human αMyHC promoter. We have now identified a region of the αMyHC promoter that binds a factor whose expression is increased sixfold in failing human hearts. Through peptide mass spectrometry, we identified this binding activity to be a heterodimer of Ku70 and Ku80. Expression of Ku represses the human αMyHC promoter in neonatal rat ventricular myocytes. Moreover, overexpression of Ku70/80 decreases αMyHC mRNA expression and increases skeletal α-actin. Interestingly, YY1 interacts with Ku70 and Ku80 in HeLa cells. Together, YY1, Ku70, and Ku80 repress the αMyHC promoter to an extent that is greater than that with YY1 or Ku70/80 alone. Our results suggest that Ku is an important factor in the repression of the human αMyHC promoter during heart failure.

scholarly journals Effects of myosin heavy chain manipulation in experimental heart failure

2010 ◽  
Vol 48 (5) ◽  
pp. 999-1006 ◽  
Author(s):  
Jeanne James ◽  
Kan Hor ◽  
Michael-Alice Moga ◽  
Lisa Ann Martin ◽  
Jeffrey Robbins
Keyword(s):  
Heart Failure ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Experimental Heart Failure
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