Transcranial Doppler and Cortical Microcirculation at Increased Intracranial Pressure and during the Cushing Response

Neurosurgery ◽  
1995 ◽  
Vol 36 (1) ◽  
pp. 147???157
Author(s):  
Karl Ungersb??ck ◽  
Dirk Tenckhoff ◽  
Axel Heimann ◽  
Wolfgang Wagner ◽  
Oliver S. Kempski
Author(s):  
Mahmoud M. Allam ◽  
Hatem A. Almasry ◽  
Sandra M. Ahmed ◽  
Youssuf G. Taha ◽  
Mohammed I. Oraby

Abstract Background Idiopathic intracranial hypertension (IIH) is a disorder of increased intracranial pressure without a clear cause and can have serious visual effects. Previous research work suggests that transcranial Doppler measurements of pulsatility index correlate accurately with elevated intracranial pressure. Objective To assess the cerebrovascular hemodynamic changes in patients with IIH using transcranial Doppler before and after lumbar puncture and CSF withdrawal. Methods An interventional study conducted on 40 patients (31 females and 9 males) fulfilling the modified Dandy criteria for diagnosis of idiopathic intracranial hypertension, MRI brain, and MRV was done to the patients. Lumbar puncture was done for all included patients to measure intracranial pressure and CSF withdrawal. Transcranial Doppler was performed for all included before and after lumbar puncture and CSF withdrawal and the following parameters were measured: peak systolic velocity (PSV), end diastolic velocity (EDV), resistivity index (RI), and pulsatility index (PI). Results Significant relation was found between grades of papilledema and PSV, RI, and PI (p value 0.012, 0.025, 0.016) but no significant relation was found between grades of papilledema and EDV (0.102). Significant changes occurred in parameters of TCD pre- and post-CSF withdrawal including PSV, EDV, and PI (p value 0.001, 0.015, 0.019) denoting a significant change in cerebral hemodynamics after CSF withdrawal which denotes a decrease in intracranial pressure. Conclusion Increased intracranial pressure significantly affects cerebral blood flow. A normalization of transcranial Doppler parameters occurs following lowering of intracranial pressure through lumbar puncture and CSF withdrawal.


1994 ◽  
Vol 17 (2) ◽  
pp. 151-156
Author(s):  
Dag Moskopp ◽  
Gerd Kehl ◽  
Christoph Horch ◽  
Zoltan Pusk�s ◽  
Hansdetlef Wassmann ◽  
...  

1989 ◽  
Vol 4 (1_suppl) ◽  
pp. S87-S90 ◽  
Author(s):  
Alexis Norelle ◽  
Asma Q. Fischer ◽  
Ann M. Flannery

The ability to discriminate between ventriculomegaly and hydrocephalus often relies on clinical impression and parameters such as change in ventricular size and configuration, increasing head circumference, and evidence of developmental delay. In an effort to confirm clinical impressions, 24 children underwent transcranial doppler (TCD). All had ventriculomegaly confirmed by computerized cranial tomography (CT), magnetic resonance imaging (MRI), and/or cranial ultrasound (CS). Fifteen were infants and nine were older children with closed fontanelles. Three patient groups were established. Group 1 included those patients with ventriculomegaly but no clinical evidence of increased intracranial pressure. Group 2 included those children with hydrocephalus and evidence of increased intracranial pressure. The last group consisted of hydrocephalic children who had shunts placed for increased pressure. The Gosling pulsatility index (PI) as well as the peak systolic velocity (PS) as measured by the TCD were compared in all three groups. The PI was found to be a useful indicator of increased intracranial pressure and need for eventual shunt. Transcranial doppler sonography may therefore prove useful as a noninvasive, easily reproducible screening tool to evaluate children with hydrocephalus. (J Child Neurol 1989;4:S87-S90).


1988 ◽  
Vol 68 (5) ◽  
pp. 745-751 ◽  
Author(s):  
Werner Hassler ◽  
Helmuth Steinmetz ◽  
Jan Gawlowski

✓ Transcranial Doppler ultrasonography was used to monitor 71 patients suffering from intracranial hypertension with subsequent brain death. Among these, 29 patients were also assessed for systemic arterial pressure and epidural intracranial pressure, so that a correlation between cerebral perfusion pressure and the Doppler ultrasonography waveforms could be established. Four-vessel angiography was also performed in 33 patients after clinical brain death. With increasing intracranial pressure, the transcranial Doppler ultrasonography waveforms exhibited different characteristic high-resistance profiles with first low, then zero, and then reversed diastolic flow velocities, depending on the relationship between intracranial pressure and blood pressure (that is, cerebral perfusion pressure). This study shows that transcranial. Doppler ultrasonography may be used to assess the degree of intracranial hypertension. This technique further provides a practicable, noninvasive bedside monitor of therapeutic measures.


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