Induction of Bone Formation Using a Recombinant Adenoviral Vector Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model

Neurosurgery ◽  
1998 ◽  
Vol 43 (3) ◽  
pp. 703-703
Author(s):  
Neill M. Wright ◽  
K. Daniel Riew ◽  
Su-Li Cheng ◽  
Louis V. Avioli ◽  
Jueren Lou
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Adenoviral Vector ◽  
Fusion Model ◽  
Recombinant Adenoviral Vector

In Vitro andIn Vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene

2001 ◽  
Vol 68 (2) ◽  
pp. 87-94 ◽  
Author(s):  
S-L Cheng ◽  
J. Lou ◽  
N. M. Wright ◽  
C. F. Lai ◽  
L. V. Avioli ◽  
...  
Keyword(s):  
Bone Formation ◽  
Adenoviral Vector ◽  
Recombinant Adenoviral Vector

scholarly journals Effect of Whitlockite as a new bone substitute for bone formation in spinal fusion and ectopic ossification animal model

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Yuan-Zhe Jin ◽  
Guang-Bin Zheng ◽  
Minjoon Cho ◽  
Jae Hyup Lee
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Tricalcium Phosphate ◽  
Transverse Process ◽  
Posterolateral Fusion ◽  
Fusion Model ◽  
Ectopic Ossification ◽  
Spinal Fusion Surgery ◽  
Sd Rat ◽  
Ectopic Bone

Abstract Background Bone substrates like hydroxyapatite and tricalcium phosphate have been widely used for promoting spinal fusion and reducing the complications caused by autograft. Whitlockite has been reported to promote better bone formation in rat calvaria models compare with them, but no study investigated its effect on spinal fusion yet. Also, the higher osteoinductivity of whitlockite raised concern of ectopic ossification, which was a complication of spinal fusion surgery that should be avoided. Methods In this study, we compared the osteoinductivity of whitlockite, hydroxyapatite, and tricalcium phosphate porous particles with SD rat spine posterolateral fusion model and investigated whether whitlockite could induce ectopic ossification with SD rat abdominal pouch model. Results The micro-CT result from the posterolateral fusion model showed whitlockite had slightly but significantly higher percent bone volume than tricalcium phosphate, though none of the materials formed successful fusion with surrounding bone tissue. The histology results showed the bone formed on the cortical surface of the transverse process but did not form a bridge between the processes. The result from the abdominal pouch model showed whitlockite did not induce ectopic bone formation. Conclusion Whitlockite had a potential of being a better bone substrate hydroxyapatite and tricalcium phosphate in spinal fusion with low risk of inducing ectopic ossification.

scholarly journals Nell-1 Protein Promotes Bone Formation in a Sheep Spinal Fusion Model

2011 ◽  
Vol 17 (7-8) ◽  
pp. 1123-1135 ◽  
Author(s):  
Ronald K. Siu ◽  
Steven S. Lu ◽  
Weiming Li ◽  
Julie Whang ◽  
Gabriel McNeill ◽  
...  
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Fusion Model

scholarly journals Magnesium hydroxide-incorporated PLGA composite attenuates inflammation and promotes BMP2-induced bone formation in spinal fusion

2020 ◽  
Vol 11 ◽  
pp. 204173142096759
Author(s):  
Tarek M. Bedair ◽  
Chang Kyu Lee ◽  
Da-Seul Kim ◽  
Seung-Woon Baek ◽  
Hanan M. Bedair ◽  
...  
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Magnesium Hydroxide ◽  
Inflammatory Responses ◽  
Composite Scaffold ◽  
Bone Morphogenetic Protein 2 ◽  
In Vitro Test ◽  
Fusion Model

Spinal fusion has become a common surgical technique to join two or more vertebrae to stabilize a damaged spine; however, the rate of pseudarthrosis (failure of fusion) is still high. To minimize pseudarthrosis, bone morphogenetic protein-2 (BMP2) has been approved for use in humans. In this study, we developed a poly(lactide-co-glycolide) (PLGA) composite incorporated with magnesium hydroxide (MH) nanoparticles for the delivery of BMP2. This study aimed to evaluate the effects of released BMP2 from BMP2-immobilized PLGA/MH composite scaffold in an in vitro test and an in vivo mice spinal fusion model. The PLGA/MH composite films were fabricated via solvent casting technique. The surface of the PLGA/MH composite scaffold was modified with polydopamine (PDA) to effectively immobilize BMP2 on the PLGA/MH composite scaffold. Analyzes of the scaffold revealed that using PLGA/MH-PDA improved hydrophilicity, degradation performance, neutralization effects, and increased BMP2 loading efficiency. In addition, releasing BMP2 from the PLGA/MH scaffold significantly promoted the proliferation and osteogenic differentiation of MC3T3-E1 cells. Furthermore, the pH neutralization effect significantly increased in MC3T3-E1 cells cultured on the BMP2-immobilized PLGA/MH scaffold. In our animal study, the PLGA/MH scaffold as a BMP2 carrier attenuates inflammatory responses and promotes BMP2-induced bone formation in posterolateral spinal fusion model. These results collectively demonstrate that the BMP2-immobilized PLGA/MH scaffold offers great potential in effectively inducing bone formation in spinal fusion surgery.

Autologous bone marrow cells implantation induces bone formation in a sheep spinal fusion model

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S154
Author(s):  
Y. Qian ◽  
Z. Lin ◽  
J. Chen ◽  
Y. Fan ◽  
T. Davey ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Spinal Fusion ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Fusion Model ◽  
Autologous Bone ◽  
Marrow Cells

scholarly journals Erythropoietin augments bone formation in a rabbit posterolateral spinal fusion model

2011 ◽  
Vol 30 (7) ◽  
pp. 1083-1088 ◽  
Author(s):  
Jan Hendrik Duedal Rölfing ◽  
Michael Bendtsen ◽  
Jonas Jensen ◽  
Maik Stiehler ◽  
Casper Bindzus Foldager ◽  
...  
Keyword(s):  
Bone Formation ◽  
Spinal Fusion ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion
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