Comparison of 1-Year Follow-up Evaluations of Patients with Indication for Pallidotomy Who Did Not Undergo Surgery versus Patients with Parkinson's Disease Who Did Undergo Pallidotomy: A Case Control Study

Neurosurgery ◽  
1999 ◽  
Vol 44 (3) ◽  
pp. 468-468 ◽  
Author(s):  
Andres Lozano
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Non-motor features of Parkinson’s disease in a nested case–control study of US men

2018 ◽  
Vol 89 (12) ◽  
pp. 1288-1295 ◽  
Author(s):  
Katherine C Hughes ◽  
Xiang Gao ◽  
Jessica M Baker ◽  
Christopher Stephen ◽  
Iris Y Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Rapid Eye Movement Sleep ◽  
Sleep Behaviour ◽  
Nested Case Control ◽  
Control Study ◽  
Smell Identification

BackgroundSeveral non-motor features may individually contribute to identify prodromal Parkinson’s disease (PD), but little is known on how they interact.MethodsWe conducted a case–control study nested within the Health Professionals Follow-up Study in a large cohort of men age 40–75 at recruitment in 1986. Cases (n=120) had confirmed PD, were<85 in January 2012, returned a 2012 questionnaire with questions on probable rapid eye movement sleep behaviour disorder (RBD) and constipation sent to all cohort participants and completed in 2014 the Brief Smell Identification Test and a questionnaire assessing parkinsonism and other non-motor PD features (including depressive symptoms, excessive daytime sleepiness, impaired colour vision and body pain). Controls (n=6479) met the same criteria as cases, except for the PD diagnosis.ResultsConcurrent constipation, probable RBD and hyposmia were present in 29.3% of cases and 1.1% of controls, yielding an age-adjusted OR of 160(95%CI 72.8to353) for three features versus none. The odds of PD increased exponentially with additional non-motor features (OR for 6–7 features versus none: 1325; 95%CI333to5279). Among men without PD, the number of non-motor features was associated with odds of parkinsonism (OR for 6–7 features versus none: 89; 95%CI21.2to375). We estimated that in a population with a prodromal PD prevalence of 2%, concurrent constipation, probable RBD and hyposmia would have a maximum sensitivity of 29% and a positive predictive value (PPV) of 35%. The PPV could increase up to 70% by including additional features, but with sharply decreased sensitivity.ConclusionsConcurrent constipation, probable RBD and hyposmia are strongly associated with PD. Because these features often precede motor symptoms and their co-occurrence could provide an efficient method for early PD identification.

Recurrent falls in Parkinson’s disease after one year of follow-up: A nested case-control study

2016 ◽  
Vol 65 ◽  
pp. 17-24 ◽  
Author(s):  
Tatjana Gazibara ◽  
Darija Kisic Tepavcevic ◽  
Marina Svetel ◽  
Aleksandra Tomic ◽  
Iva Stankovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Recurrent Falls ◽  
One Year ◽  
Nested Case Control ◽  
Control Study

Comparison of 1-Year Follow-up Evaluations of Patients with Indication for Pallidotomy Who Did Not Undergo Surgery versus Patients with Parkinson's Disease Who Did Undergo Pallidotomy: A Case Control Study

Neurosurgery ◽  
1999 ◽  
Vol 44 (3) ◽  
pp. 461-467 ◽  
Author(s):  
Marcelo Merello ◽  
Maria Ines Nouzeilles ◽  
Angel Cammarota ◽  
Osvaldo Betti ◽  
Ramón Leiguarda
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Study of cognitive impairment and genetic polymorphism of SLC41A1 (rs11240569 allele) in Parkinson’s disease in Upper Egypt: case-control study

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Hamdy N. El-Tallawy ◽  
Tahia H. Saleem ◽  
Wafaa M. Farghaly ◽  
Heba Mohamed Saad Eldien ◽  
Ashraf Khodaery ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Motor Symptoms ◽  
And Control ◽  
Non Motor Symptoms ◽  
Control Study

Abstract Background Parkinson’s disease is one of the neurodegenerative disorders that is caused by genetic and environmental factors or interaction between them. Solute carrier family 41 member 1 within the PARK16 locus has been reported to be associated with Parkinson’s disease. Cognitive impairment is one of the non-motor symptoms that is considered a challenge in Parkinson’s disease patients. This study aimed to investigate the association of rs11240569 polymorphism; a synonymous coding variant in SLC41A1 in Parkinson’s disease patients in addition to the assessment of cognitive impairment in those patients. Results In a case -control study, rs11240569 single nucleotide polymorphisms in SLC41A1, genes were genotyped in 48 Parkinson’s disease patients and 48 controls. Motor and non-motor performance in Parkinson's disease patients were assessed by using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). The genotype and allele frequencies were compared between the two groups and revealed no significant differences between case and control groups for rs11240569 in SLC41A1 gene with P value .523 and .54, respectively. Cognition was evaluated and showed the mean ± standard deviation (SD) of WAIS score of PD patients 80.4 ± 9.13 and the range was from 61 to 105, in addition to MMSE that showed mean ± SD 21.96 ± 3.8. Conclusion Genetic testing of the present study showed that rs11240569 polymorphism of SLC41A1 gene has no significant differences in distributions of alleles and genotypes between cases and control group, in addition to cognitive impairment that is present in a large proportion of PD patients and in addition to the strong correlation between cognitive impairment and motor and non-motor symptoms progression.

1.128 Are there multisensory defcits in early Parkinson's disease? A case-control study

2007 ◽  
Vol 13 ◽  
pp. S40-S41
Author(s):  
V. Pieri ◽  
M. Vaillant ◽  
S. Blyth ◽  
G. Hipp ◽  
N.J. Diederich
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Early Parkinson’S Disease ◽  
Control Study

Carotid intima-media thickness in Parkinson's disease: a retrospective case control-study

2020 ◽  
Vol 79 ◽  
pp. e38
Author(s):  
C.A. Soto-Rincón ◽  
S.A. Castillo Torres ◽  
D.G. Marítnez-Roque ◽  
J. Duarte-Bravo ◽  
S. España-Pérez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Case Control ◽  
Retrospective Case ◽  
Media Thickness ◽  
Control Study

scholarly journals Familial aggregation of Parkinson's disease in a multiethnic community-based case-control study

2010 ◽  
Vol 25 (15) ◽  
pp. 2587-2594 ◽  
Author(s):  
Michael Y. Shino ◽  
Valerie McGuire ◽  
Stephen K. Van Den Eeden ◽  
Caroline M. Tanner ◽  
Rita Popat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Familial Aggregation ◽  
Case Control ◽  
Community Based ◽  
Control Study

Tumor diagnosis preceding Parkinson's disease: A case-control study

2004 ◽  
Vol 19 (7) ◽  
pp. 807-811 ◽  
Author(s):  
Marco D'Amelio ◽  
Paolo Ragonese ◽  
Letterio Morgante ◽  
Antonio Epifanio ◽  
Graziella Callari ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Tumor Diagnosis ◽  
Control Study
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