Detection of Human Immunodeficiency Virus Type 1 and Type 2 in the Female Genital Tract: Implications for the Understanding of Virus Transmission

1999 ◽  
Vol 54 (Supplement) ◽  
pp. 187-196
Author(s):  
Cathy W. Critchlow ◽  
Nancy B. Kiviat
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Virus Transmission ◽  
Immunodeficiency Virus ◽  
Female Genital

scholarly journals Correlation between Human Immunodeficiency Virus Type 1 RNA Levels in the Female Genital Tract and Immune Activation Associated with Ulceration of the Cervix

2000 ◽  
Vol 181 (6) ◽  
pp. 1950-1956 ◽  
Author(s):  
Stephen D. Lawn ◽  
Shambavi Subbarao ◽  
Thomas C. Wright, Jr. ◽  
Tammy Evans‐Strickfaden ◽  
Tedd V. Ellerbrock ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immune Activation ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Immunodeficiency Virus ◽  
Female Genital ◽  
Rna Levels

scholarly journals Association between Bacterial Vaginosis and Expression of Human Immunodeficiency Virus Type 1 RNA in the Female Genital Tract

2001 ◽  
Vol 33 (6) ◽  
pp. 894-896 ◽  
Author(s):  
Susan Cu‐Uvin ◽  
Joseph W. Hogan ◽  
Angela M. Caliendo ◽  
Joseph Harwell ◽  
Kenneth H. Mayer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Bacterial Vaginosis ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Immunodeficiency Virus ◽  
Female Genital

scholarly journals Correlation of Human Immunodeficiency Virus Type 1 RNA Levels in Blood and the Female Genital Tract

1999 ◽  
Vol 179 (4) ◽  
pp. 871-882 ◽  
Author(s):  
Clyde E. Hart ◽  
Jeffrey L. Lennox ◽  
Melody Pratt‐Palmore ◽  
Thomas C. Wright ◽  
Raymond F. Schinazi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Immunodeficiency Virus ◽  
Female Genital ◽  
Rna Levels

scholarly journals Detection and Quantitation of Human Immunodeficiency Virus Type 1 in the Female Genital Tract

2000 ◽  
Vol 38 (10) ◽  
pp. 3822-3824 ◽  
Author(s):  
Penny Baron ◽  
James Bremer ◽  
Steven S. Wasserman ◽  
Marek Nowicki ◽  
Barbara Driscoll ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Female Genital Tract ◽  
Rna Detection ◽  
Immunodeficiency Virus ◽  
Cervicovaginal Lavage ◽  
Hiv 1 ◽  
Female Genital

Human immunodeficiency virus type 1 (HIV-1) was detected in the genital tracts of 59% of 225 women by RNA PCR and in 7% of the women by culture. In a comparison of two sampling methods, endocervical swabs were more sensitive than cervicovaginal lavage for HIV-1 RNA detection by PCR but not by culture and their sensitivity was independent of the concentration of HIV-1 RNA.

scholarly journals Penetration of the Nucleoside Analogue Abacavir into the Genital Tract of Men Infected with Human Immunodeficiency Virus Type 1

2001 ◽  
Vol 33 (8) ◽  
pp. e91-e92 ◽  
Author(s):  
Rieneke M. E. van Praag ◽  
Rolf P. G. van Heeswijk ◽  
Suzanne Jurriaans ◽  
Joep M. A. Lange ◽  
Richard M. W. Hoetelmans ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Nucleoside Analogue ◽  
Genital Tract ◽  
Immunodeficiency Virus

scholarly journals Differential Transmission of Human Immunodeficiency Virus Type 1 by Distinct Subsets of Effector Dendritic Cells

2002 ◽  
Vol 76 (15) ◽  
pp. 7812-7821 ◽  
Author(s):  
Rogier W. Sanders ◽  
Esther C. de Jong ◽  
Christopher E. Baldwin ◽  
Joost H. N. Schuitemaker ◽  
Martien L. Kapsenberg ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Dendritic Cells ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Virus Transmission ◽  
Viral Envelope ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Dendritic cells (DC) support human immunodeficiency virus type 1 (HIV-1) transmission by capture of the virus particle in the mucosa and subsequent transport to the draining lymph node, where HIV-1 is presented to CD4+ Th cells. Virus transmission involves a high-affinity interaction between the DC-specific surface molecule DC-SIGN and the viral envelope glycoprotein gp120 and subsequent internalization of the virus, which remains infectious. The mechanism of viral transmission from DC to T cells is currently unknown. Sentinel immature DC (iDC) develop into Th1-promoting effector DC1 or Th2-promoting DC2, depending on the activation signals. We studied the ability of these effector DC subsets to support HIV-1 transmission in vitro. Compared with iDC, virus transmission is greatly upregulated for the DC1 subset, whereas DC2 cells are inactive. Increased transmission by DC1 correlates with increased expression of ICAM-1, and blocking studies confirm that ICAM-1 expression on DC is important for HIV transmission. The ICAM-1-LFA-1 interaction is known to be important for immunological cross talk between DC and T cells, and our results indicate that this cell-cell contact is exploited by HIV-1 for efficient transmission.

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