COMPARISON OF SKIN ALLOGRAFT REJECTION AND CYTOTOXIC ANTIBODY PRODUCTION IN TWO LINES OF MICE GENETICALLY SELECTED FOR ???HIGH??? AND ???LOW??? ANTIBODY SYNTHESIS

1972 ◽  
Vol 14 (5) ◽  
pp. 590-596 ◽  
Author(s):  
M Liacopoulos-Briot ◽  
Y Bouthillier ◽  
D Mouton ◽  
F Lambert ◽  
C Decreusefond ◽  
...  
Keyword(s):  
Antibody Production ◽  
Allograft Rejection ◽  
Skin Allograft ◽  
Antibody Synthesis ◽  
Cytotoxic Antibody

Cutaneous CsA-resistant veiled (dendritic) cells are responsible for uncontrolled skin allograft rejection

2001 ◽  
Vol 33 (1-2) ◽  
pp. 445-447 ◽  
Author(s):  
H Galkowska ◽  
M Moscicka ◽  
E Cybulska ◽  
U Wojewodzka ◽  
J Mijal ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Allograft Rejection ◽  
Skin Allograft

scholarly journals Quantitative assessment of mouse skin transplant rejection using digital photography

2005 ◽  
Vol 39 (2) ◽  
pp. 209-214 ◽  
Author(s):  
F Schwoebel ◽  
J Barsig ◽  
A Wendel ◽  
J Hamacher
Keyword(s):  
Allograft Rejection ◽  
Transplant Rejection ◽  
Immunosuppressive Treatment ◽  
Mouse Skin ◽  
Digital Photography ◽  
In Vivo Model ◽  
Skin Allograft ◽  
Monitoring Method ◽  
Early Stages

Mouse skin transplantation is an established in vivo model used to investigate the T-cell-mediated immune response of acute allograft rejection. The critical endpoint of this model is complete rejection of the allograft. However, visual judgement of this end stage of rejection is an arbitrary process and difficult to standardize. To overcome this problem, we established a monitoring method based on digital photography. Serial pictures from skin allografts of individual animals (C57BL/6 on BALB/c) were taken with a digital camera mounted on a microsurgical microscope. Thereby, the description and the correct assessment of early stages of rejection were possible due to the magnification of grafts by the microscope. Rejection scores were introduced to describe different stages from retained to completely rejected grafts. With cyclosporine A as a standard immunosuppressive treatment, we showed that early stages of skin rejection were unambiguously identified. This procedure allows the earlier termination of the experiment and reduction of animal distress, and it can be re-evaluated anywhere and any time after completion. This study demonstrates the suitability of monitoring experimental skin allograft rejection by digital photography, entailing several refinements in animal experimentation, both for the researcher and for the animal.

QUALITATIVE AND TEMPORAL DIFFERENCES BETWEEN RENAL, CARDIAC AND SKIN ALLOGRAFT REJECTION IN MICE

2004 ◽  
Vol 78 ◽  
pp. 513-514
Author(s):  
V F. Moxham ◽  
R Hangartner ◽  
K J. Wood ◽  
S H. Sacks ◽  
W Wong
Keyword(s):  
Allograft Rejection ◽  
Skin Allograft ◽  
Temporal Differences

Inhibition of Skin Allograft Rejection and Acute Graft-Versus-Host Disease by Cis-Urocanic Acid

1992 ◽  
Vol 98 (4) ◽  
pp. 459-462 ◽  
Author(s):  
Stefan Gruner ◽  
Wolfgang Diezel ◽  
Heiko Stoppe ◽  
Horst Oesterwitz ◽  
Wolfgang Henke
Keyword(s):  
Graft Versus Host Disease ◽  
Allograft Rejection ◽  
Urocanic Acid ◽  
Skin Allograft ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

Comparison of Antimouse and Antihorse Antibody Production during the Treatment of Allograft Rejection with OKT3 or Antithymocyte Globulin

Nephron ◽  
1987 ◽  
Vol 46 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Charles F. Shield, III ◽  
Douglas J. Norman ◽  
Patricia Marlett ◽  
Anthony J. Fucello ◽  
Gideon Goldstein
Keyword(s):  
Antibody Production ◽  
Allograft Rejection ◽  
Antithymocyte Globulin

scholarly journals Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection

2014 ◽  
Vol 45 (2) ◽  
pp. 452-463 ◽  
Author(s):  
Carolina Moore ◽  
Gabriela Tejon ◽  
Camila Fuentes ◽  
Yessia Hidalgo ◽  
Maria R. Bono ◽  
...  
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Regulatory T Cells ◽  
Allograft Rejection ◽  
Skin Allograft
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