International Multisite Double-Blind Trial of the Atypical Antipsychotics Risperidone and Olanzapine in 175 Elderly Patients With Chronic Schizophrenia

2003 ◽  
Vol 11 (6) ◽  
pp. 638-647 ◽  
Author(s):  
Dilip V. Jeste ◽  
Yoram Barak ◽  
Subramoniam Madhusoodanan ◽  
Fred Grossman ◽  
Georges Gharabawi
1965 ◽  
Vol 111 (475) ◽  
pp. 527-529 ◽  
Author(s):  
J. T. Robinson ◽  
L. S. Davies ◽  
Norman Kreitman ◽  
J. B. Knowles

Oxypertine is a new piperazine derivative, believed to have tranquillizing, antiadrenergic and hypotensive properties. Unpublished reports have suggested that it might be useful in chronic schizophrenia, although the recent study by Calwell et al. (1964) shows that its usefulness in this condition is limited. In view of its putative tranquillizing effect, the present clinical trial was undertaken to determine, under double-blind conditions, its efficacy as an adjunctive treatment for chronic anxiety neurosis. Ratings of anxiety symptoms were the major criteria for assessing the patients' progress, but the IPAT Anxiety Scale (Cattell and Scheier, 1957) was also included as a potentially useful measure of anxiety. An investigation of its validity was a subsidiary aim of the study.


1980 ◽  
Vol 8 (1) ◽  
pp. 18-21 ◽  
Author(s):  
L Knorring Von

A double-blind controlled study of viloxazine against placebo in elderly depressed patients with a primary diagnosis of depressive illness records statistically significant improvements in depression ratings in the viloxazine group after three weeks. Viloxazine was effective and well tolerated at doses of 100 to 200 mg in depressed elderly patients, several of whom had concurrent cardiac disease.


1973 ◽  
Vol 7 (1) ◽  
pp. 52-57 ◽  
Author(s):  
M. J. Weston ◽  
R. Bentley ◽  
A. Unwin ◽  
M. Morris ◽  
M. A. Harper

A double-blind trial was conducted which attempted to compare and contrast the therapeutic effects of haloperidol and thioridazine in a chronic schizophrenic population. The psychiatric use of these two drugs, one a butyrophenone, the other a phenothiazine, is discussed with reference to the management of this clinical population.


2014 ◽  
Vol 42 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Mustafa Said Aydogan ◽  
Soner Demirel ◽  
Mehmet Ali Erdogan ◽  
Penpegul Firat ◽  
Cemil Colak ◽  
...  

1970 ◽  
Vol 117 (541) ◽  
pp. 683-684 ◽  
Author(s):  
P. A. Morris ◽  
D. H. MacKenzie ◽  
H. C. Masheter

Pimozide is a new neuroleptic drug and is chemically described as bis-para-fluoro-phenyl-butylpiperidine. It is active after oral administration, with a 24 hour duration of action and a peak effect lasting four to six hours (1). Superiority over placebo has been demonstrated by Brugmans (2).


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