Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender

2003 ◽  
Vol 13 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Beverly H. Brummett ◽  
Ilene C. Siegler ◽  
Douglas R. McQuoid ◽  
Ingrid K. Svenson ◽  
Douglas A. Marchuk ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Personality Inventory ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Region ◽  
Neo Personality Inventory ◽  
Neo Personality Inventory Revised ◽  
And Gender

scholarly journals Moderation of antidepressant response by the serotonin transporter gene

2009 ◽  
Vol 195 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Patricia Huezo-Diaz ◽  
Rudolf Uher ◽  
Rebecca Smith ◽  
Marcella Rietschel ◽  
Neven Henigsberg ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Severe Depression ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Antidepressant Response ◽  
Therapeutic Drugs ◽  
Noradrenaline Reuptake ◽  
Antidepressant Effects ◽  
And Gender

BackgroundThere have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene.AimsTo test the hypothesis that the 5-HTTLPR differently influences response to escitalopram (an SSRI) compared with nortriptyline (a noradrenaline reuptake inhibitor).MethodThe 5-HTTLPR and 13 additional markers across the serotonin transporter gene were genotyped in 795 adults with moderate-to-severe depression treated with escitalopram or nortriptyline in the Genome Based Therapeutic Drugs for Depression (GENDEP) project.ResultsThe 5-HTTLPR moderated the response to escitalopram, with long-allele carriers improving more than short-allele homozygotes. A significant three-way interaction between 5-HTTLPR, drug and gender indicated that the effect was concentrated in males treated with escitalopram. The single-nucleotide polymorphism rs2020933 also influenced outcome.ConclusionsThe effect of 5-HTTLPR on antidepressant response is SSRI specific conditional on gender and modulated by another polymorphism at the 5' end of the serotonin transporter gene.

Functional Cortical Effects of Novel Allelic Variants of the Serotonin Transporter Gene-linked Polymorphic Region (5-HTTLPR) in Humans

2007 ◽  
Vol 40 (5) ◽  
pp. 191-195 ◽  
Author(s):  
J. Gallinat ◽  
D. Müller ◽  
J. Bierbrauer ◽  
H. Rommelspacher ◽  
G. Juckel ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Region ◽  
Allelic Variants

Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa

Life Sciences ◽  
1997 ◽  
Vol 61 (21) ◽  
pp. PL295-PL303 ◽  
Author(s):  
A. Hinney ◽  
N. Barth ◽  
A. Ziegler ◽  
S. Von Prittwitz ◽  
A. Hamann ◽  
...  
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Region
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