CUSHINGʼS SYNDROME CAUSED BY ECTOPIC ACTH SECRETION FROM PULMONARY CARCINOID UNDETECTED BY OCTREOTIDE SCAN: A CASE REPORT.

2004 ◽  
Vol 52 ◽  
pp. S163
Author(s):  
M. B. Hemphill ◽  
K. M. Colleran
Keyword(s):  
Case Report ◽  
Acth Secretion ◽  
Ectopic Acth ◽  
Pulmonary Carcinoid ◽  
Ectopic Acth Secretion ◽  
Octreotide Scan

Case report: Ectopic ACTH secretion due to a metastatic atypical lung carcinoid tumor. From diagnosis to treatment

2019 ◽  
Vol 80 (2) ◽  
pp. 137-139
Author(s):  
Ellen Hoornaert ◽  
Laurence Jacqmin ◽  
Luc Montfort ◽  
Dominique Maiter ◽  
Luc Derdelinckx
Keyword(s):  
Case Report ◽  
Carcinoid Tumor ◽  
Acth Secretion ◽  
Ectopic Acth ◽  
Ectopic Acth Secretion ◽  
Lung Carcinoid

scholarly journals Possible pitfalls in the workup of ectopic ACTH secretion illustrated by four rare cases

2019 ◽  
Vol 12 (11) ◽  
pp. e231067
Author(s):  
Jorianne Boers ◽  
P Christine Oldenburg-Ligtenberg ◽  
Aline ME Stades ◽  
Mark JC van Treijen
Keyword(s):  
Case Report ◽  
Adrenocorticotropic Hormone ◽  
Progressive Disease ◽  
Diagnostic Workup ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Acth Secretion ◽  
Ectopic Acth ◽  
Ectopic Acth Secretion ◽  
Ectopic Adrenocorticotropic Hormone

In this case report, we highlight four different cases of ectopic adrenocorticotropic hormone (ACTH) secretion with different pitfalls in the diagnostic workup. Ectopic ACTH secretion (EAS) is an uncommon cause of Cushing’s syndrome that accompanies a variety of tumours. It is associated with significant morbidity and mortality. This underlines the importance of early and adequate diagnosis. We will review the causes of EAS and their presentation to increase awareness of this rare and progressive disease.

scholarly journals Ectopic ACTH Secretion in a Child With Metastatic Ewing's Sarcoma: A Case Report

2020 ◽  
Vol 10 ◽  
Author(s):  
Valentina Di Ruscio ◽  
Giada Del Baldo ◽  
Maria Debora De Pasquale ◽  
Rita De Vito ◽  
Evelina Miele ◽  
...  
Keyword(s):  
Case Report ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Acth Secretion ◽  
Ectopic Acth ◽  
Ectopic Acth Secretion

scholarly journals Cushing’s Syndrome due to Ectopic ACTH from Bronchial Carcinoid: A Case Report and Review

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Manohara Kenchaiah ◽  
Steve Hyer
Keyword(s):  
Case Report ◽  
Cushing’S Syndrome ◽  
Dynamic Testing ◽  
Imaging Techniques ◽  
Cushing's Syndrome ◽  
Bronchial Carcinoid ◽  
Adrenocorticotrophic Hormone ◽  
Acth Secretion ◽  
Ectopic Acth ◽  
Ectopic Acth Secretion

Despite advances in analytic and imaging techniques, the syndrome of ectopic adrenocorticotrophic hormone (ACTH) secretion from a tumour resulting in Cushing’s syndrome continues to pose difficult diagnostic and therapeutic challenges. Dynamic testing may be equivocal and radiology indeterminate. We report a patient presenting with Cushing’s syndrome associated with ectopic ACTH secretion from a bronchial carcinoid whose management presented diagnostic and therapeutic challenges.

scholarly journals The value of corticotropin-releasing hormone (CRH) test for differential diagnosis of Cushing’s syndrome

2007 ◽  
Vol 135 (1-2) ◽  
pp. 31-37 ◽  
Author(s):  
Zorana Penezic ◽  
Milos Zarkovic ◽  
Svetlana Vujovic ◽  
Miomira Ivovic ◽  
Biljana Beleslin ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Roc Curve ◽  
Acth Secretion ◽  
Ectopic Acth ◽  
Ectopic Acth Secretion ◽  
Test Sensitivity ◽  
Basal Cortisol ◽  
Area Under Roc Curve ◽  
Curve Method ◽  
Acth Secreting

Introduction: Diagnosis and differential diagnosis of Cushing?s syndrome (CS) remain considerable challenge in endocrinology. For more than 20 years, CRH has been widely used as differential diagnostic test. Following the CRH administration, the majority of patients with ACTH secreting pituitary adenoma show a significant rise of plasma cortisol and ACTH, whereas those with ectopic ACTH secretion characteristically do not. Objective The aim of our study was to assess the value of CRF test for differential diagnosis of CS using the ROC (receiver operating characteristic) curve method. Method A total of 30 patients with CS verified by pathological examination and postoperative testing were evaluated. CRH test was performed within diagnostic procedures. ACTH secreting pituitary adenoma was found in 18, ectopic ACTH secretion in 3 and cortisol secreting adrenal adenoma in 9 of all patients with CS. Cortisol and ACTH were determined -15, 0, 15, 30, 45, 60, 90 and 120 min. after i.v. administration of 100?g of ovine CRH. Cortisol and ACTH were determined by commercial RIA. Statistical data processing was done by ROC curve analysis. Due to small number, the patients with ectopic ACTH secretion were excluded from test evaluation by ROC curve method. Results In evaluated subgroups, basal cortisol was (1147.3?464.3 vs. 1589.8?296.3 vs. 839.2?405.6 nmol/L); maximal stimulated cortisol (1680.3?735.5 vs. 1749.0?386.6 vs. 906.1?335.0 nmol/L); and maximal increase as a percent of basal cortisol (49.1?36.9 vs. 9.0?7.6 vs. 16.7?37.3 %). Consequently, basal ACTH was (100.9 ?85.0 vs. 138.0?123.7 vs. 4.8?4.3 pg/mL) and maximal stimulated ACTH (203.8 ?160.1 vs. 288.0?189.5 vs. 7.4?9.2 pg/mL). For cortisol, determination area under ROC curve was 0.815?0.083 (CI 95% 0.652-0.978). For cortisol increase cut-off level of 20%, test sensitivity was 83%, with specificity of 78%. For ACTH, determination area under ROC curve was 0.637?0.142 (CI 95% 0.359-0.916). For ACTH increase cut-off level of 30%, test sensitivity was 70%, with specificity of 57%. Conclusion Determination of cortisol and ACTH levels in CRH test remains reliable tool in differential diagnosis of Cushing?s syndrome.

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