In Vitro Metabolism of Methylene Ohloride in Human and Animal Tissues: Use in Physiologically Based Pharmacokinetic Models???

Journal of Occupational and Environmental Medicine ◽

10.1097/00043764-199005000-00004 ◽

1990 ◽

Vol 32 (5) ◽

pp. 421

Author(s):

Elizabeth E. Gresch

Keyword(s):

In Vitro Metabolism ◽

Pharmacokinetic Models ◽

Animal Tissues ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models

Toxicology and Applied Pharmacology ◽

10.1016/0041-008x(89)90328-1 ◽

1989 ◽

Vol 97 (2) ◽

pp. 230-246 ◽

Author(s):

R.H. Reitz ◽

A.L. Mendrala ◽

F.P. Guengerich

Keyword(s):

Methylene Chloride ◽

In Vitro Metabolism ◽

Pharmacokinetic Models ◽

Animal Tissues ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2084 ◽

2017 ◽

Vol 38 (7) ◽

pp. 439-442 ◽

Author(s):

Masahiro Utoh ◽

Tomonori Miura ◽

Takashi Kusama ◽

Shotaro Uehara ◽

Makiko Shimizu ◽

...

Keyword(s):

Cytochrome P450 ◽

Pharmacokinetic Models ◽

Cytochrome P450 2C9 ◽

Cynomolgus Monkeys ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Journal of Traditional Chinese Medical Sciences ◽

10.1016/j.jtcms.2021.07.006 ◽

2021 ◽

Author(s):

Yang Liu ◽

Jing Sun ◽

Lin Ying Zhong ◽

Yu Li ◽

A Na Er ◽

...

Keyword(s):

Classification System ◽

Pharmacokinetic Models ◽

Absorption Properties ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Biopharmaceutic Classification System

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Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models

Drug Metabolism and Disposition ◽

10.1124/dmd.120.090928 ◽

2020 ◽

Vol 48 (9) ◽

pp. 769-777 ◽

Author(s):

Makiko Yamada ◽

Tomoko Ishizuka ◽

Shin-ichi Inoue ◽

Veronika Rozehnal ◽

Thomas Fischer ◽

...

Keyword(s):

Risk Assessment ◽

Drug Interaction ◽

In Vitro Studies ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models

Toxicology in Vitro ◽

10.1016/s0887-2333(97)00056-8 ◽

1997 ◽

Vol 11 (5) ◽

pp. 473-478 ◽

Author(s):

J.B. Houston ◽

D.J. Carlile

Keyword(s):

Drug Metabolism ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Pesticide Exposures ◽

Physiologically Based

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Usage of In Vitro Metabolism Data for Drug‐Drug Interaction in Physiologically Based Pharmacokinetic Analysis Submissions to the US Food and Drug Administration

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1819 ◽

2021 ◽

Author(s):

Jieon Lee ◽

Yuching Yang ◽

Xinyuan Zhang ◽

Jianghong Fan ◽

Manuela Grimstein ◽

...

Keyword(s):

Drug Interaction ◽

Drug Administration ◽

Food And Drug Administration ◽

In Vitro Metabolism ◽

Pharmacokinetic Analysis ◽

Physiologically Based Pharmacokinetic ◽

The Us ◽

Physiologically Based ◽

Drug Drug Interaction

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Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-16 ◽

2006 ◽

pp. 301-348 ◽

Author(s):

Robert De Woskin ◽

Chadwick Thompson ◽

Weihsueh Chiu ◽

Paul Schlosser ◽

Carolyn Smallwood ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Integrated Risk ◽

Physiologically Based

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