Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2084 ◽

2017 ◽

Vol 38 (7) ◽

pp. 439-442 ◽

Author(s):

Masahiro Utoh ◽

Tomonori Miura ◽

Takashi Kusama ◽

Shotaro Uehara ◽

Makiko Shimizu ◽

...

Keyword(s):

Cytochrome P450 ◽

Pharmacokinetic Models ◽

Cytochrome P450 2C9 ◽

Cynomolgus Monkeys ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models

Xenobiotica ◽

10.1080/00498254.2017.1393121 ◽

2017 ◽

Vol 48 (10) ◽

pp. 1072-1077 ◽

Author(s):

Takashi Kusama ◽

Akiko Toda ◽

Makiko Shimizu ◽

Shotaro Uehara ◽

Takashi Inoue ◽

...

Keyword(s):

Cytochrome P450 ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Cytochrome P450 2C19 ◽

Physiologically Based

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Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Journal of Traditional Chinese Medical Sciences ◽

10.1016/j.jtcms.2021.07.006 ◽

2021 ◽

Author(s):

Yang Liu ◽

Jing Sun ◽

Lin Ying Zhong ◽

Yu Li ◽

A Na Er ◽

...

Keyword(s):

Classification System ◽

Pharmacokinetic Models ◽

Absorption Properties ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Biopharmaceutic Classification System

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R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys

Xenobiotica ◽

10.1080/00498254.2017.1288945 ◽

2017 ◽

Vol 48 (2) ◽

pp. 206-210 ◽

Author(s):

Masahiro Utoh ◽

Takashi Kusama ◽

Tomonori Miura ◽

Marina Mitsui ◽

Mirai Kawano ◽

...

Keyword(s):

Cytochrome P450 ◽

Pharmacokinetic Models ◽

Cynomolgus Monkeys ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Cytochrome P450 2C19 ◽

Physiologically Based

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Response to “Ethnic-Specific In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Approaches to Predict Cytochrome P450-Mediated Pharmacokinetics in Chinese Population: Opportunities and Challenges”

Clinical Pharmacokinetics ◽

10.1007/s40262-013-0118-x ◽

2013 ◽

Vol 53 (2) ◽

pp. 203-203 ◽

Author(s):

Zoe E. Barter ◽

Geoffrey T. Tucker ◽

Karen Rowland-Yeo

Keyword(s):

Cytochrome P450 ◽

Chinese Population ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug Disposition

Journal of Pharmaceutical Sciences ◽

10.1002/jps.10128 ◽

2002 ◽

Vol 91 (5) ◽

pp. 1358-1370 ◽

Author(s):

Patrick Poulin ◽

Frank-Peter Theil

Keyword(s):

Drug Disposition ◽

In Vivo Studies ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models

Drug Metabolism and Disposition ◽

10.1124/dmd.120.090928 ◽

2020 ◽

Vol 48 (9) ◽

pp. 769-777 ◽

Author(s):

Makiko Yamada ◽

Tomoko Ishizuka ◽

Shin-ichi Inoue ◽

Veronika Rozehnal ◽

Thomas Fischer ◽

...

Keyword(s):

Risk Assessment ◽

Drug Interaction ◽

In Vitro Studies ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models

Toxicology in Vitro ◽

10.1016/s0887-2333(97)00056-8 ◽

1997 ◽

Vol 11 (5) ◽

pp. 473-478 ◽

Author(s):

J.B. Houston ◽

D.J. Carlile

Keyword(s):

Drug Metabolism ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models

Toxicology and Applied Pharmacology ◽

10.1016/0041-008x(89)90328-1 ◽

1989 ◽

Vol 97 (2) ◽

pp. 230-246 ◽

Author(s):

R.H. Reitz ◽

A.L. Mendrala ◽

F.P. Guengerich

Keyword(s):

Methylene Chloride ◽

In Vitro Metabolism ◽

Pharmacokinetic Models ◽

Animal Tissues ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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In Vitro Metabolism of Methylene Ohloride in Human and Animal Tissues: Use in Physiologically Based Pharmacokinetic Models???

Journal of Occupational and Environmental Medicine ◽

10.1097/00043764-199005000-00004 ◽

1990 ◽

Vol 32 (5) ◽

pp. 421

Author(s):

Elizabeth E. Gresch

Keyword(s):

In Vitro Metabolism ◽

Pharmacokinetic Models ◽

Animal Tissues ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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