What do the terms “genetic predisposition” and “genetic heterogeneity” mean in relation to inflammatory bowel disease?

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The incidence of inflammatory bowel disease is 5.2/100,000 children less than 16 years in the UK. Crohn’s disease is the commonest form of inflammatory bowel disease followed by ulcerative colitis and indeterminate colitis. The precise aetiology of inflammatory bowel disease is unknown and reflects a complex interaction between genetic predisposition, immune dysfunction, and environmental triggers.


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