Effect of High- and Low-Frequency Transcutaneous Electrical Nerve Stimulation on Angiogenesis and Myofibroblast Proliferation in Acute Excisional Wounds in Rat Skin

2016 ◽  
Vol 29 (8) ◽  
pp. 357-363 ◽  
Author(s):  
Aline F. P. Machado ◽  
Richard E. Liebano ◽  
Fabianne Furtado ◽  
Bernardo Hochman ◽  
Lydia M. Ferreira
Keyword(s):  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Low Frequency ◽  
Rat Skin ◽  
Electrical Nerve Stimulation

scholarly journals Effect of high- and low- frequency transcutaneous electrical nerve stimulation (TENS) on angiogenesis and wound contraction in acute excisional wounds in rat skin

2017 ◽  
Vol 30 (4) ◽  
pp. 671-680
Author(s):  
Aline Fernanda Perez Machado ◽  
Fabio Leite Silva ◽  
Marco Aurélio Invaldi Neves ◽  
Fábio Luis Nonato ◽  
Pascale Mutti Tacani ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
High Frequency ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Low Frequency ◽  
Repair Process ◽  
Wound Contraction ◽  
Rat Skin ◽  
Electrical Nerve Stimulation ◽  
Frequency Group ◽  
Excisional Wound

Abstract Introduction: Transcutaneous electrical nerve stimulation (TENS) can alter the local temperature, increase skin blood flow and induce the release of vasodilator neuropeptides and growth factors. These changes may be related to the effects of TENS on the tissue repair process. Objective: To assess the effect of high- and low-frequency TENS on angiogenesis and the contraction of acute excisional wounds in rat skin. Methods: Fifty-four young adult male EPM1-Wistar rats were used in the study. An excisional wound was performed on the back of each animal using an 8mm punch. The animals were randomly assigned to three groups: the High-frequency Group (HG: 80 Hz), Low-frequency Group (LG: 5 Hz), and Sham Group (SG: TENS turned off). TENS was delivered on three days consecutives. Pulse duration and current intensity were 200 µs and 15 mA. The length of each TENS session was 60 minutes. Microscopic and macroscopic assessments were performed on 3, 7 and 14 postoperative (PO) days. Hematoxylin-eosin staining was utilized to quantify the neoformed blood vessels. Photographs were taken to determine the percentage of wound contraction. After assessment, the animals were painlessly sacrificed. Results: There were increases in angiogenesis in the HG on the 3 PO day, and in the LG on the 14 PO day. No significant differences in wound contraction were found between the groups on the different PO days. Conclusion: High frequency TENS improved angiogenesis, and neither frequency of TENS had any influence on the contraction of acute excisional wounds in rat skin.

Antihypertensive effect of low-frequency transcutaneous electrical nerve stimulation (TENS) in comparison with drug treatment

2012 ◽  
Vol 21 (5) ◽  
pp. 306-310 ◽  
Author(s):  
Jonas Silverdal ◽  
Georgios Mourtzinis ◽  
Elisabet Stener-Victorin ◽  
Clas Mannheimer ◽  
Karin Manhem
Keyword(s):  
Drug Treatment ◽  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Antihypertensive Effect ◽  
Low Frequency ◽  
Electrical Nerve Stimulation

scholarly journals Effect of low frequency transcutaneous electrical nerve stimulation of TE5 (waiguan) and PC6 (neiguan) acupoints on cold-induced pain

2016 ◽  
Vol 28 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Eduardo José Nepomuceno Montenegro ◽  
Geisa Guimarães de Alencar ◽  
Gisela Rocha de Siqueira ◽  
Marcelo Renato Guerino ◽  
Juliana Netto Maia ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Low Frequency ◽  
Electrical Nerve Stimulation ◽  
Stimulation Of

scholarly journals Transcutaneous Electrical Nerve Stimulation for the Management of Neuropathic Pain: The Effects of Frequency and Electrode Position on Prevention of Allodynia in a Rat Model of Complex Regional Pain Syndrome Type II

2006 ◽  
Vol 86 (5) ◽  
pp. 698-709 ◽  
Author(s):  
David L Somers ◽  
F Richard Clemente
Keyword(s):  
Complex Regional Pain Syndrome ◽  
Nerve Stimulation ◽  
High Frequency ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Low Frequency ◽  
Pain Syndrome ◽  
Syndrome Type ◽  
Type Ii ◽  
Electrical Nerve Stimulation ◽  
The Right

Abstract Background and Purpose. Complex regional pain syndrome type II (CPSII) is a painful condition that develops following a nerve injury. Although transcutaneous electrical nerve stimulation (TENS) relieves the pain of CPSII, the stimulation parameters that would best prevent the development of the condition are not known. The purpose of this study was to compare the ability of several different stimulation strategies to reduce the development of allodynia. Subjects. Sprague-Dawley rats were used in the study. Methods. A chronic constriction injury (CCI) to the right sciatic nerve was used to induce allodynia. Two groups of CCI rats received high-frequency TENS to the lumbar paravertebral region with electrodes positioned on the skin overlying either the right or left paraspinal musculature. Two additional groups of CCI rats received low-frequency TENS to acupuncture points in the right or left hind limbs. A fifth group of CCI rats received no TENS intervention. Thermal and mechanical pain thresholds were assessed in the right hind paw before and 12 days after the CCI surgery. The TENS was delivered 1 hour per day beginning on the day of surgery. Results. Daily high-frequency TENS reduced the development of mechanical allodynia in CCI rats, and low-frequency TENS reduced the development of thermal allodynia, but only when TENS was delivered on the left side. Discussion and Conclusion. The results indicate that TENS delivered contralateral to a nerve injury best reduces allodynia development. Comprehensive reduction of allodynia development would require a combination of high- and low-frequency TENS intervention.

scholarly journals Blood Flow Changes in the Trapezius Muscle and Overlying Skin Following Transcutaneous Electrical Nerve Stimulation

2007 ◽  
Vol 87 (8) ◽  
pp. 1047-1055 ◽  
Author(s):  
Margareta L Sandberg ◽  
Matilda K Sandberg ◽  
Johanna Dahl
Keyword(s):  
Blood Flow ◽  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Muscle Blood Flow ◽  
Low Frequency ◽  
Trapezius Muscle ◽  
Sensory Level ◽  
Electrical Nerve Stimulation ◽  
To Receive ◽  
Level 2

Background and Purpose: Various researchers have studied the effects of transcutaneous electrical nerve stimulation (TENS) on hemodynamics. The purpose of this study was to examine the effects of TENS on local blood flow in the trapezius muscle and overlying skin. Subjects: Thirty-three women who were healthy, aged 25 to 55 years, were randomly assigned to receive 1 of 3 different modes of TENS. Methods: Skin and muscle blood flow were monitored noninvasively using a new application of photoplethysmography for 15 minutes of TENS applied at high frequency (80 Hz) and sensory-level intensity and at low frequency (2 Hz) and motor-level intensity and for 15 minutes after stimulation. Subliminal 80-Hz TENS was used as a control. Blood flow was monitored simultaneously on stimulated and nonstimulated shoulders. Results: Blood flow in the trapezius muscle, but not skin blood flow, increased significantly with motor-level 2-Hz TENS, whereas no increase occurred with sensory-level 80-Hz TENS or subliminal 80-Hz TENS. Discussion and Conclusion: Muscle contractions induced by motor-level 2-Hz TENS appear to be a prerequisite for increasing blood flow in the trapezius muscle. However, high stimulation intensity may prevent increased blood flow in the overlying skin.

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