Potential Use of Sox9 Gene Therapy for Intervertebral Degenerative Disc Disease

Spine ◽  
2003 ◽  
Vol 28 (8) ◽  
pp. 755-763 ◽  
Author(s):  
Ronjon Paul ◽  
Rex C. Haydon ◽  
Hongwei Cheng ◽  
Akira Ishikawa ◽  
Nikola Nenadovich ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Sox9 Gene ◽  
Potential Use

scholarly journals Gene therapy for degenerative disc disease

Gene Therapy ◽  
2004 ◽  
Vol 11 (4) ◽  
pp. 390-401 ◽  
Author(s):  
S Sobajima ◽  
JS Kim ◽  
LG Gilbertson ◽  
JD Kang
Keyword(s):  
Gene Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc

Molecular Biology of Degenerative Disc Disease

Neurosurgery ◽  
2000 ◽  
Vol 47 (5) ◽  
pp. 1034-1040 ◽  
Author(s):  
Bernard H. Guiot ◽  
Richard G. Fessler
Keyword(s):  
Growth Factors ◽  
Degenerative Disc Disease ◽  
Molecular Level ◽  
Morphological Changes ◽  
Proteoglycan Synthesis ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Active Investigation ◽  
Potential Use

Abstract THE INTERVERTEBRAL DISC is a complex anatomic and biochemical structure. It is composed primarily of fibrocytes and chondrocytes that are anatomically segregated in an elaborate avascular macromolecular matrix of collagen and proteoglycans. Degenerative processes associated with aging and trauma result in morphological and molecular changes to the disc. Morphological changes are observed as dehydration, fissuring, and tearing of the nucleus, annulus, and endplates. On the molecular level, degenerative changes include decreased diffusion, decreased cell viability, decreased proteoglycan synthesis, and alteration in collagen distribution. The role of inflammatory mediators in these processes, and the potential use of growth factors to delay or reverse the degenerative cascade, is poorly understood. However, these areas are under active investigation, the results of which may soon contribute significantly to our understanding of degenerative disc disease.

Mesenchymanl Stem Cell Based Intradiscal Gene Therapy: Therapeutic Implication in Degenerative Disc Disease

2004 ◽  
Vol 11 (2) ◽  
pp. 67
Author(s):  
Hyang Kim ◽  
Un-Hye Kwon ◽  
Kwang-Il Lee ◽  
Ki-Hong Song ◽  
Sung-Yeop Shin ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Degenerative Disc Disease ◽  
Therapeutic Implication ◽  
Disc Disease ◽  
Degenerative Disc

Regeneration Potential of Stem Cell in the Treatment of IVD

2021 ◽  
Vol 9 (8) ◽  
pp. 3022-3036
Author(s):  
Riya Bhanushali
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Intervertebral Disc ◽  
Stem Cell Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Potential Use

Abstract: Degenerative disc disease is a prevalent musculoskeletal disorder in which damaged spinal discs cause pain upon aging, accidental injuries. Spinal discs connect adjacent vertebrae and help in maintaining mobility, flexibility and rotation of spinal cord. Spinal discs also act as shock absorbers. Intervertebral disc (IVD) degeneration is often associated with low back and neck pain, which accounts for disability worldwide. Physical therapy, spinal fusion surgeries reduce severity and symptoms of degenerative disc disease but they are not complete cure for this disease. Current preclinical studies show that mesenchymal stem cells have the capacity to repair degenerative disks by differentiation to chondrocyte-like cells, which produce proteoglycans and type II collagen. Mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs), adipose tissue (AD-MSCs) and umbilical cord (UC-MSCs) show potential use in cartilage and intervertebral disc (IVD) repair. Regenerative medicine and stem cell therapy hold great promise for treatment of intervertebral disc (IVD) disease. This review discusses about progression of degenerative disc disease, various types of stem cells, potential use of mesenchymal stem cells (MSCs) and embryonic stem cells (ESCs) for the treatment of degenerative disc disease. This review also focuses upon challenges encountered by the application of stem cell therapy for treating degenerative disc disease as well as future perspectives. Keywords: IVD, Stem cell therapy, AF & NP cells, MSCs, Scaffolds, Cell therapy

Hubungan Kadar Lipid Darah Dengan Degenerative Disc Disease Berdasarkan Klasifikasi Pfirrmann Menggunakan Magnetic Resonance Imaging Lumbosacral pada Pasien Nyeri Punggung Bawah

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Ryan Indra ◽  
Muhammad Ilyas ◽  
Mirna Muis ◽  
Bachtiar Murtala ◽  
Andi Alfian ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Degenerative Disc Disease ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Resonance Imaging ◽  
Disc Disease ◽  
Degenerative Disc

Penelitian ini bertujuan mengetahui hubungan serum lipid darah dengan degenerative disc disease berdasarkan klasifikasi pfirrmann menggunakan magnetic resonance imaging lumbosacral pada pasien nyeri punggung bawah. Penelitian ini dilaksanakan di Departemen Radiologi RS. Dr. Wahidin Sudirohusodo Makassar mulai bulan Oktober 2018 sampai Januari 2019. Subjek sebanyak 52 orang dengan rentang usia 30 - 60 tahun. Metode yang digunakan adalah uji Spearman. Hasil penelitian menunjukkan terdapat korelasi antara kadar low-density lipoprotein (LDL) dan trigliserida serum dengan degenerative disc disease dengan nilai p=0.02 (p0.05). Semakin tinggi kadar LDL dan trigliserida maka derajat degerative disc disease cendereng semakin berat. Tidak terdapat korelasi antara HDL dengan degenerative disc disease. Secara statistik tidak terdapat korelasi antara kolesterol total dengan degenerative disc disease. Namun, didapatkan pada grafik nilai kolesterol total pada setiap derajat degenerative disc disease meningkat.

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