Adenosine A2A receptor activation reduces lung injury in trauma/hemorrhagic shock*

2006 ◽  
Vol 34 (4) ◽  
pp. 1119-1125 ◽  
Author(s):  
György Haskó ◽  
Da-Zhong Xu ◽  
Qi Lu ◽  
Zoltán H. Németh ◽  
Jondavid Jabush ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

Adenosine A2A receptor activation: Another potential therapy for trauma and hemorrhagic shock*

2006 ◽  
Vol 34 (4) ◽  
pp. 1273-1275 ◽  
Author(s):  
Rongqian Wu ◽  
Ping Wang
Keyword(s):  
Hemorrhagic Shock ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A2A receptor activation

2008 ◽  
Vol 136 (5) ◽  
pp. 1280-1288 ◽  
Author(s):  
Turner C. Lisle ◽  
Leo M. Gazoni ◽  
Lucas G. Fernandez ◽  
Ashish K. Sharma ◽  
Andrew M. Bellizzi ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Injury ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

8A. Inflammatory Lung Injury After Cardiopulmonary Bypass is Attenuated by Adenosine A2A Receptor Activation

2009 ◽  
Vol 151 (2) ◽  
pp. 176
Author(s):  
T.C. Lisle ◽  
L.M. Gazoni ◽  
L.G. Fernandez ◽  
A.K. Sharma ◽  
A.M. Bellizzi ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Injury ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals A Cellular Assay for the Identification and Characterization of Connexin Gap Junction Modulators

2021 ◽  
Vol 22 (3) ◽  
pp. 1417
Author(s):  
Azeem Danish ◽  
Robin Gedschold ◽  
Sonja Hinz ◽  
Anke C. Schiedel ◽  
Dominik Thimm ◽  
...  
Keyword(s):  
Gap Junctions ◽  
Small Molecules ◽  
High Throughput Screening ◽  
Cell Communication ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
Intracellular Camp ◽  
Donor Cells ◽  
A2a Receptor ◽  
Adenosine A2a

Connexin gap junctions (Cx GJs) enable the passage of small molecules and ions between cells and are therefore important for cell-to-cell communication. Their dysfunction is associated with diseases, and small molecules acting as modulators of GJs may therefore be useful as therapeutic drugs. To identify GJ modulators, suitable assays are needed that allow compound screening. In the present study, we established a novel assay utilizing HeLa cells recombinantly expressing Cx43. Donor cells additionally expressing the Gs protein-coupled adenosine A2A receptor, and biosensor cells expressing a cAMP-sensitive GloSensor luciferase were established. Adenosine A2A receptor activation in the donor cells using a selective agonist results in intracellular cAMP production. The negatively charged cAMP migrates via the Cx43 gap junctions to the biosensor cells and can there be measured by the cAMP-dependent luminescence signal. Cx43 GJ modulators can be expected to impact the transfer of cAMP from the donor to the biosensor cells, since cAMP transit is only possible via GJs. The new assay was validated by testing the standard GJ inhibitor carbenoxolon, which showed a concentration-dependent inhibition of the signal and an IC50 value that was consistent with previously reported values. The assay was demonstrated to be suitable for high-throughput screening.

scholarly journals Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices

Neuroscience ◽  
2003 ◽  
Vol 122 (1) ◽  
pp. 111-121 ◽  
Author(s):  
T. Almeida ◽  
R.J. Rodrigues ◽  
A. de Mendonça ◽  
J.A. Ribeiro ◽  
R.A. Cunha
Keyword(s):  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Receptor Activation ◽  
P2 Receptors ◽  
Adenosine A2a Receptor ◽  
Adenosine Release ◽  
Term Potentiation ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals P3-214: ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATES NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE

2019 ◽  
Vol 15 ◽  
pp. P1012-P1012
Author(s):  
Gemma Navarro Brugal ◽  
David Aguinaga ◽  
Irene Reyes ◽  
Iu Raïch ◽  
Anna Del Ser ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Alzheimer Disease ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
Receptor Function ◽  
A2a Receptor ◽  
Nmda Receptor Function ◽  
Adenosine A2a

Adenosine A2A receptor activation reduces brain metastasis via SDF‐1/CXCR4 axis and protecting blood‐brain barrier

2020 ◽  
Vol 59 (4) ◽  
pp. 390-398 ◽  
Author(s):  
Lei Chen ◽  
Liangdong Li ◽  
Changshuai Zhou ◽  
Xin Chen ◽  
Yiqun Cao
Keyword(s):  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
Brain Barrier ◽  
Blood Brain ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Cxcr4 Axis

scholarly journals Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes

2015 ◽  
Vol 11 (4) ◽  
pp. 607-612 ◽  
Author(s):  
Sandra Henriques Vaz ◽  
Sofia Rapaz Lérias ◽  
Sara Parreira ◽  
Maria José Diógenes ◽  
Ana Maria Sebastião
Keyword(s):  
Glutamate Release ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia–reperfusion injury

2010 ◽  
Vol 139 (2) ◽  
pp. 474-482 ◽  
Author(s):  
Ashish K. Sharma ◽  
Victor E. Laubach ◽  
Susan I. Ramos ◽  
Yunge Zhao ◽  
George Stukenborg ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

Augmented release of serotonin by adenosine A2a receptor activation and desensitization by CGS 21680 in the rat nucleus tractus solitarius

1996 ◽  
Vol 733 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Robin A Barraco ◽  
Carolyn Clough Helfman ◽  
Gordon F Anderson
Keyword(s):  
Nucleus Tractus Solitarius ◽  
Receptor Activation ◽  
Adenosine A2a Receptor ◽  
Cgs 21680 ◽  
A2a Receptor ◽  
Adenosine A2a
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