Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis*

2007 ◽  
Vol 35 (12) ◽  
pp. 2686-2692 ◽  
Author(s):  
Kevin B. Laupland ◽  
Andrew W. Kirkpatrick ◽  
Anthony Delaney
Keyword(s):  
Systematic Review ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Intravenous Immunoglobulin ◽  
Critically Ill ◽  
Meta Analysis ◽  
Critically Ill Adults ◽  
Sepsis And Septic Shock ◽  
Ill Adults

scholarly journals Polyclonal Intravenous Immunoglobulin for the Prophylaxis and Treatment of Infection in Critically Ill Adults

2002 ◽  
Vol 13 (2) ◽  
pp. 100-106 ◽  
Author(s):  
Kevin B Laupland
Keyword(s):  
Septic Shock ◽  
Intravenous Immunoglobulin ◽  
Critically Ill ◽  
Meta Analysis ◽  
Standard Of Care ◽  
Streptococcal Toxic Shock Syndrome ◽  
Clinical Equipoise ◽  
Recommended Treatment ◽  
Critically Ill Adults ◽  
Sepsis And Septic Shock

Infection is a major cause of morbidity and mortality in critically ill patients. Despite advances in technology, its mortality rate has changed minimally over the past two decades, and new therapies are needed. Polyclonal intravenous immunoglobulin (IVIG) has been investigated both as a preventive and a treatment modality for sepsis and septic shock in critically ill adult patients. Prophylaxis with IVIG has been shown to reduce significantly the incidence of infection, particularly pneumonia, in selected postsurgical intensive care patients. However, it does not reduce mortality. The risk-benefit and cost effectiveness of this therapeutic intervention have not been determined, and its routine use is therefore not recommended. Treatment with IVIG has been shown in a number of small trials and a meta-analysis to reduce dramatically sepsis and septic shock mortality. However, a large, unpublished randomized trial has apparently shown no mortality benefit with this therapy. Despite limited evidence, IVIG has become the standard of care for the management of group A streptococcal toxic shock syndrome. At present, clinical equipoise exists for the use of IVIG in the treatment of sepsis and septic shock, and further study is needed.

scholarly journals Erratum: Prospective immune profiling in critically ill adults: before, during and after severe sepsis and septic shock

Critical Care ◽  
2015 ◽  
Vol 19 (1) ◽  
Author(s):  
N. Layios ◽  
C. Gosset ◽  
C. Delierneux ◽  
A. Hego ◽  
J. Huart ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Adults ◽  
Sepsis And Septic Shock ◽  
Ill Adults ◽  
Immune Profiling

scholarly journals Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis

BMJ ◽  
2004 ◽  
Vol 329 (7464) ◽  
pp. 480 ◽  
Author(s):  
Djillali Annane ◽  
Eric Bellissant ◽  
Pierre Edouard Bollaert ◽  
Josef Briegel ◽  
Didier Keh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Meta Analysis ◽  
Sepsis And Septic Shock

scholarly journals Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review

BMJ ◽  
2009 ◽  
Vol 338 (may21 1) ◽  
pp. b1574-b1574 ◽  
Author(s):  
K. E A Burns ◽  
N. K J Adhikari ◽  
S. P Keenan ◽  
M. Meade
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Meta Analysis ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Critically Ill Adults ◽  
Ill Adults

scholarly journals Intensity of Continuous Renal Replacement Therapies in Patients with Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis

2011 ◽  
Vol 39 (3) ◽  
pp. 373-383 ◽  
Author(s):  
J. Latour-Pérez ◽  
E. Palencia-Herrejón ◽  
V. Gómez-Tello ◽  
A. Baeza-Román ◽  
M. á. García-García ◽  
...  
Keyword(s):  
Systematic Review ◽  
Septic Shock ◽  
Severe Sepsis ◽  
Meta Analysis ◽  
Renal Replacement Therapies ◽  
Continuous Renal Replacement Therapies ◽  
Sepsis And Septic Shock

Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis

2015 ◽  
Vol 41 (8) ◽  
pp. 1393-1401 ◽  
Author(s):  
Manu Shankar-Hari ◽  
Nicholas Culshaw ◽  
Benjamin Post ◽  
Eduardo Tamayo ◽  
David Andaluz-Ojeda ◽  
...  
Keyword(s):  
Systematic Review ◽  
Critically Ill ◽  
Meta Analysis ◽  
Critically Ill Adults ◽  
Ill Adults
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