scholarly journals 579: MAGNESIUM SULFATE CONTINUOUS INFUSION IN CHILDREN WITH STATUS ASTHMATICUS

2021 ◽  
Vol 50 (1) ◽  
pp. 281-281
Author(s):  
KHALID TAHER ◽  
Peter Johnson ◽  
Jamie Miller ◽  
Stephen Neely ◽  
Neha Gupta
Keyword(s):  
Magnesium Sulfate ◽  
Continuous Infusion ◽  
Status Asthmaticus

8: IMPACT OF LATE USE MAGNESIUM SULFATE IN INNER CITY CHILDREN HOSPITALIZED FOR ASTHMA EXACERBATION

2016 ◽  
Vol 64 (3) ◽  
pp. 802.1-802
Author(s):  
P Shukla ◽  
E Aragona ◽  
J Wang ◽  
D Pillai
Keyword(s):  
Length Of Stay ◽  
Magnesium Sulfate ◽  
Severe Asthma ◽  
Asthma Exacerbation ◽  
Status Asthmaticus ◽  
Asthma Severity ◽  
Day Length ◽  
Multiple Doses ◽  
Significant Difference ◽  
The Impact

Purpose of StudyAsthma is typically treated acutely with β2-agonists and systemic steroids. Adjunctive therapies such as magnesium sulfate (MgSO4) have proven useful with early addition potentially improving clinical outcomes in asthma (reduced hospital admission rates, length of stay and intubation rates). Exact administration time and impact on outcomes in children are not fully understood. We sought to identify the impact of timing of initiating MgSO4 therapy in innercity children admitted for status asthmaticus.Methods UsedWe performed a retrospective chart review of children (age 2–21 yrs) admitted to a children's hospital over a 12 month period with asthma exacerbation and administered MgSO4. Data collected included ethnicity, gender, medications, timing of interventions, length of stay, BMI percentile, comorbidities and NAEPP asthma severity. Statistical analysis performed with SPSS 22.Summary of Results150 innercity children were admitted for asthma exacerbation and received MgSO4 during the study period. 85% were African American, 36% female, 39% had moderate/severe asthma and mean time to initial MgSO4 was 3.8 hours from triage. Those receiving initial MgSO4 after 4 hours were more likely to receive multiple doses of MgSO4 (OR2.8 [95%CI:1.4–5.6]). Time of initial MgSO4 dose (<4 vs. >4 hrs) showed no significant difference in other parameters including age, obesity, asthma severity, and comorbidities. A sub-analysis of children that received 1 dose vs. >1 MgSO4 dose demonstrated that those receiving >1 MgSO4 doses were more likely to be obese (OR2.7 [1.3–5.7]), have moderate/severe asthma (OR3.2 [1.6–6.8]) and have increased length of stay (p=0.005) and charges (p=0.042). Additionally, obese children (OR8.9 [2.2–35.2]), and intermittent/mild asthmatic children (OR6.4 [1.2–31.2]) receiving >1 MgSO4 dose were more likely to have >2 day length of stay.ConclusionsDelay in administration of MgSO4 in children hospitalized for status asthmaticus may be associated with poor outcomes including multiple doses of MgSO4 which in turn is associated with longer length of stay and increased charges. Obesity and asthma severity are important factors associated with these outcomes. A prospective analysis in a larger cohort is recommended to further evaluate these findings.

scholarly journals Continuous Infusion of Magnesium Sulfate (MgSO4) in the Management of Severe Asthma in Children. • 238

1996 ◽  
Vol 39 ◽  
pp. 42-42
Author(s):  
Talaat Abdelmoneim ◽  
Mariano Fiallos ◽  
Niranjan Kissoon
Keyword(s):  
Magnesium Sulfate ◽  
Continuous Infusion ◽  
Severe Asthma ◽  
Asthma In Children

scholarly journals Magnesium Infusion for Refractory Non-surgical Pheochromocytoma Crisis

2019 ◽  
Vol 7 (30) ◽  
pp. 47-50
Author(s):  
Chelsea Kristin Krueger ◽  
Kimberly A Turner ◽  
Raymond A Moreno ◽  
Biosha B Jones ◽  
Olakunle Idowu
Keyword(s):  
Case Report ◽  
Magnesium Sulfate ◽  
Continuous Infusion ◽  
Severe Hypertension ◽  
Low Cost ◽  
Multiorgan Failure ◽  
Therapeutic Index ◽  
Medical Emergency ◽  
Adrenergic Antagonist ◽  
Widespread Availability

Pheochromocytoma crisis is a rare medical emergency characterized by severe hypertension, shock, and multiorgan failure. Despite its widespread availability, low cost and wide therapeutic index, magnesium sulfate has primarily been utilized as an adrenergic antagonist during pheochromocytoma resection. This case report describes a 57-year-old male with recurrent nonsurgical pheochromocytoma and crisis refractory to adrenergic antagonism. Initiation of magnesium sulfate continuous infusion provided rapid hemodynamic control in the setting of inoperable disease. This case highlights the role and dosing of magnesium sulfate in the management of pheochromocytoma crisis.

Intravenous magnesium sulfate treatment in a child with status asthmaticus

1999 ◽  
Vol 56 (10) ◽  
pp. 997-1000 ◽  
Author(s):  
Jean G. Dib ◽  
Fayette M. Engstrom ◽  
Thomas S. Sisca ◽  
Raquel M. Tiu
Keyword(s):  
Magnesium Sulfate ◽  
Status Asthmaticus ◽  
Intravenous Magnesium

High-dose magnesium sulfate infusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study

2012 ◽  
Vol 39 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Tosha A. Egelund ◽  
Sarah K. Wassil ◽  
Elisa M. Edwards ◽  
Stephan Linden ◽  
Jose E. Irazuzta
Keyword(s):  
Cohort Study ◽  
Magnesium Sulfate ◽  
Status Asthmaticus ◽  
High Dose ◽  
Infusion Protocol

High-dose intravenous magnesium sulfate in the management of life-threatening status asthmaticus — authors' reply

1995 ◽  
Vol 21 (1) ◽  
pp. 94-95
Author(s):  
M. Sydow ◽  
T. A. Crozier ◽  
S. Zielmann ◽  
J. Radke ◽  
H. Burchardi
Keyword(s):  
Magnesium Sulfate ◽  
Status Asthmaticus ◽  
High Dose ◽  
Intravenous Magnesium ◽  
Life Threatening

Treatment of Status Asthmaticus with Intravenous Magnesium Sulfate

1991 ◽  
Vol 28 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Hiroshi Okayama ◽  
Michiko Okayama ◽  
Takashi Aikawa ◽  
Midetada Sasaki ◽  
Tamotsu Takishima
Keyword(s):  
Magnesium Sulfate ◽  
Status Asthmaticus ◽  
Intravenous Magnesium
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