scholarly journals 1537: IMPACT OF DOAC REVERSAL WITH ACTIVATED PROTHROMBIN COMPLEX CONCENTRATE IN TRAUMATIC BRAIN INJURIES

2021 ◽  
Vol 50 (1) ◽  
pp. 772-772
Author(s):  
Grace Cooksey ◽  
Shaun Rowe ◽  
Leslie Hamilton ◽  
James McMillen ◽  
Jared Griffard
Keyword(s):  
Prothrombin Complex Concentrate ◽  
Brain Injuries ◽  
Traumatic Brain Injuries ◽  
Activated Prothrombin Complex Concentrate

Prothrombin Complex Concentrate Use in Coagulopathy of Lethal Brain Injuries Increases Organ Donation

2014 ◽  
Vol 80 (4) ◽  
pp. 335-338 ◽  
Author(s):  
Bellal Joseph ◽  
Hassan Aziz ◽  
Viraj Pandit ◽  
Daniel Hays ◽  
Narong Kulvatunyou ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Organ Donation ◽  
Prothrombin Complex Concentrate ◽  
Brain Injuries ◽  
Cost Effective ◽  
Gunshot Wounds ◽  
International Normalized Ratio ◽  
Traumatic Brain Injuries ◽  
Time Of Admission

Coagulopathy is a defined barrier for organ donation in patients with lethal traumatic brain injuries. The purpose of this study was to document our experience with the use of prothrombin complex concentrate (PCC) to facilitate organ donation in patients with lethal traumatic brain injuries. We performed a 4-year retrospective analysis of all patients with devastating gunshot wounds to the brain. The data were analyzed for demographics, change in international normalized ratio (INR), and subsequent organ donation. The primary end point was organ donation. Eighty-eight patients with lethal traumatic brain injury were identified from the trauma registry of whom 13 were coagulopathic at the time of admission (mean INR 2.2 ± 0.8). Of these 13 patients, 10 patients received PCC in an effort to reverse their coagulopathy. Mean INR before PCC administration was 2.01 ± 0.7 and 1.1 ± 0.7 after administration ( P < 0.006). Correction of coagulopathy was attained in 70 per cent (seven of 10) patients. Of these seven patients, consent for donation was obtained in six patients and resulted in 19 solid organs being procured. The cost of PCC per patient was $1022 ± 544. PCC effectively reveres coagulopathy associated with lethal traumatic brain injury and enabled patients to proceed to organ donation. Although various methodologies exist for the treatment of coagulopathy to facilitate organ donation, PCC provides a rapid and cost-effective therapy for reversal of coagulopathy in patients with lethal traumatic brain injuries.

Going Beyond Admiring Traumatic Brain Injuries

PsycCRITIQUES ◽  
2006 ◽  
Vol 51 (11) ◽  
Author(s):  
Walter Erich Penk
Keyword(s):  
Brain Injuries ◽  
Traumatic Brain Injuries

Severe traumatic brain injuries in the elderly

2009 ◽  
Author(s):  
N. Syrmos ◽  
Ch. Iliadis ◽  
V. Valadakis ◽  
K. Grigoriou ◽  
K. Paltatzidou ◽  
...  
Keyword(s):  
Brain Injuries ◽  
The Elderly ◽  
Traumatic Brain Injuries
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