The role of insulin-like growth factor-II mRNA-binding protein 3, cyclooxygenase-2, and galectin-3 in differentiating malignant melanoma from benign melanocytic lesion

2015 ◽  
Vol 12 (3) ◽  
pp. 203-211
Author(s):  
Rania A. El-Tatawy ◽  
Safinaz H. El-Shorbagy
Keyword(s):  
Growth Factor ◽  
Malignant Melanoma ◽  
Binding Protein ◽  
Melanocytic Lesion ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Galectin 3 ◽  
Mrna Binding

The roles of Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3) in melanoma progression

2013 ◽  
Vol 69 (2) ◽  
pp. e20-e21
Author(s):  
Chia-Yu Chu ◽  
Yi-Shuan Sheen ◽  
Kuanyin K. Lin ◽  
Meng-Chen Hsieh ◽  
Hsien-Ching Chiu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Messenger Rna ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Melanoma Progression ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice

2004 ◽  
Vol 24 (10) ◽  
pp. 4448-4464 ◽  
Author(s):  
Thomas V. O. Hansen ◽  
Niels A. Hammer ◽  
Jacob Nielsen ◽  
Mette Madsen ◽  
Charlotte Dalbaeck ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Rna Binding ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Extracellular Matrix Components ◽  
Mrna Binding Protein ◽  
Mrna Binding ◽  
Deficient Mice

ABSTRACT Insulin-like growth factor II mRNA-binding protein 1 (IMP1) belongs to a family of RNA-binding proteins implicated in mRNA localization, turnover, and translational control. Mouse IMP1 is expressed during early development, and an increase in expression occurs around embryonic day 12.5 (E12.5). To characterize the physiological role of IMP1, we generated IMP1-deficient mice carrying a gene trap insertion in the Imp1 gene. Imp1−/− mice were on average 40% smaller than wild-type and heterozygous sex-matched littermates. Growth retardation was apparent from E17.5 and remained permanent into adult life. Moreover, Imp1−/− mice exhibited high perinatal mortality, and only 50% were alive 3 days after birth. In contrast to most other organs, intestinal epithelial cells continue to express IMP1 postnatally, and Imp1−/− mice exhibited impaired development of the intestine, with small and misshapen villi and twisted colon crypts. Analysis of target mRNAs and global expression profiling at E12.5 indicated that Igf2 translation was downregulated, whereas the postnatal intestine showed reduced expression of transcripts encoding extracellular matrix components, such as galectin- 1, lumican, tenascin-C, procollagen transcripts, and the Hsp47 procollagen chaperone. Taken together, the results demonstrate that IMP1 is essential for normal growth and development. Moreover, IMP1 may facilitate intestinal morphogenesis via regulation of extracellular matrix formation.

Sign in / Sign up

Export Citation Format

Share Document