The Peroxisome Proliferator-activated Receptor ?? Activator Fenofibrate Inhibits Endothelin-1-induced Cardiac Fibroblast Proliferation

2004 ◽  
Vol 44 (Supplement 1) ◽  
pp. S279-S282 ◽  
Author(s):  
Takehiro Ogata ◽  
Takashi Miyauchi ◽  
Yoko Irukayama-Tomobe ◽  
Masakatsu Takanashi ◽  
Katsutoshi Goto ◽  
...  
Keyword(s):  
Cardiac Fibroblast ◽  
Peroxisome Proliferator ◽  
Fibroblast Proliferation ◽  
Peroxisome Proliferator Activated Receptor ◽  
Endothelin 1 ◽  
Receptor Activator

Effect of the peroxisome proliferator-activated receptor ? activator GW0742 in rat cultured cerebellar granule neurons

2004 ◽  
Vol 77 (2) ◽  
pp. 240-249 ◽  
Author(s):  
Steven A. Smith ◽  
Gregory R. Monteith ◽  
Jodie A. Robinson ◽  
Nagaraj Gopisetty Venkata ◽  
Fiona J. May ◽  
...  
Keyword(s):  
Cerebellar Granule Neurons ◽  
Peroxisome Proliferator ◽  
Granule Neurons ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cerebellar Granule ◽  
Receptor Activator

scholarly journals Peroxisome Proliferator–Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling

2016 ◽  
Vol 54 (1) ◽  
pp. 136-146 ◽  
Author(s):  
Bum-Yong Kang ◽  
Kathy K. Park ◽  
Jennifer M. Kleinhenz ◽  
Tamara C. Murphy ◽  
David E. Green ◽  
...  
Keyword(s):  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Endothelin 1

scholarly journals Peroxisome Proliferator-Activated ReceptorαReduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Hsu-Lung Jen ◽  
Po-Len Liu ◽  
Yung-Hsiang Chen ◽  
Wei-Hsian Yin ◽  
Jaw-Wen Chen ◽  
...  
Keyword(s):  
Cell Size ◽  
Underlying Mechanism ◽  
Nuclear Factor Κb ◽  
Cardiomyocyte Hypertrophy ◽  
Peroxisome Proliferator ◽  
Nuclear Factor ◽  
Mobility Shift ◽  
Peroxisome Proliferator Activated Receptor ◽  
Human Cardiomyocytes ◽  
Endothelin 1

Peroxisome proliferator-activated receptorα(PPARα) plays a role in the pathogenesis of cardiac hypertrophy, although its underlying mechanism remains unclear. The purpose of this study was to evaluate the effect of PPARαactivation on endothelin-1- (ET-1-) caused cardiomyocyte hypertrophy and explore its underlying mechanisms. Human cardiomyocytes (HCMs) were cultured with or without ET-1, whereafter the inhibitory effects of fenofibrate, a PPARαactivator, on cell size and adiponectin protein were tested. We examined the activation of extracellular signal-regulated kinase (ERK) and p38 proteins caused by ET-1 and the inhibition of the ERK and p38 pathways on ET-1-induced cell size and adiponectin expression. Moreover, we investigated the interaction of PPARαwith adiponectin and nuclear factor-κB (NF-κB) by electrophoretic mobility shift assays and coimmunoprecipitation. ET-1 treatment significantly increased cell size, suppressed PPARαexpression, and enhanced the expression of adiponectin. Pretreatment with fenofibrate inhibited the increase in cell size and enhancement of adiponectin expression. ET-1 significantly activated the ERK and p38 pathways, whereas PD98059 and SB205380, respectively, inhibited them. Our results suggest that activated PPARαcan decrease activation of adiponectin and NF-κB and inhibit ET-1-induced cardiomyocyte hypertrophy.

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