scholarly journals PF283 A RETROSPECTIVE STUDY OF MYELOID LEUKAEMIA IN CHILDREN WITH DOWN SYNDROME IN IRELAND

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 93
Author(s):  
G.P. Dowling ◽  
A. Piccin ◽  
A. O’Marcaigh ◽  
K.T. Gavin ◽  
A. Malone ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Retrospective Study ◽  
Myeloid Leukaemia ◽  
Children With Down Syndrome

scholarly journals OC52 A retrospective study of myeloid leukaemia in children with down syndrome in ireland

2019 ◽  
Author(s):  
Gavin P Dowling ◽  
Andrea Piccin ◽  
Katherine T Gavin ◽  
Aengus O’Marcaigh ◽  
Owen P Smith
Keyword(s):  
Down Syndrome ◽  
Retrospective Study ◽  
Myeloid Leukaemia ◽  
Children With Down Syndrome

A retrospective study of myeloid leukaemia in children with Down syndrome in Ireland

2020 ◽  
Vol 189 (3) ◽  
pp. 979-984
Author(s):  
Gavin P. Dowling ◽  
Andrea Piccin ◽  
Katherine T. Gavin ◽  
David R Betts ◽  
Andrea Malone ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Retrospective Study ◽  
Myeloid Leukaemia ◽  
Children With Down Syndrome

Optimal treatment intensity in children with Down syndrome and myeloid leukaemia: data from 56 children treated on NOPHO-AML protocols and a review of the literature

2006 ◽  
Vol 85 (5) ◽  
pp. 275-280 ◽  
Author(s):  
Lotte Abildgaard ◽  
Eva Ellebæk ◽  
Göran Gustafsson ◽  
Jonas Abrahamsson ◽  
Liisa Hovi ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Myeloid Leukaemia ◽  
Optimal Treatment ◽  
Treatment Intensity ◽  
Review Of The Literature ◽  
Children With Down Syndrome

scholarly journals Investigating the Link Between Trisomy 21 and Acquired Mutations in the GATA1 Gene

The Physician ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. c9
Author(s):  
Triya Chakravorty ◽  
Irene Roberts
Keyword(s):  
Down Syndrome ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Trisomy 21 ◽  
Children With Down Syndrome ◽  
Transient Abnormal Myelopoiesis ◽  
Increased Risk ◽  
Leukaemic Cells ◽  
Acute Myeloid

Children with Down syndrome (DS) due to trisomy 21 (T21) are at an increased risk of developing the neonatal preleukaemic disorder transient abnormal myelopoiesis (TAM), which may transform into childhood acute myeloid leukaemia (ML-DS). Leukaemic cells in TAM and ML-DS have acquired mutations in the GATA1 gene. Although it is clear that acquired mutations in GATA1 are necessary for the development of TAM and ML-DS, questions remain concerning the mechanisms of disease.

scholarly journals Retrospective Study of Obesity in Children with Down Syndrome

2016 ◽  
Vol 173 ◽  
pp. 143-148 ◽  
Author(s):  
Janet S. Basil ◽  
Stephanie L. Santoro ◽  
Lisa J. Martin ◽  
Katherine Wusik Healy ◽  
Barbara A. Chini ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Retrospective Study ◽  
Children With Down Syndrome ◽  
Obesity In Children

scholarly journals Thyroid Dysfunction and Its Influence in Growth Velocity in Children with Down Syndrome: A Retrospective Study

2018 ◽  
Vol 22 (1) ◽  
pp. 6-9
Author(s):  
Vidhya Vishwanathan ◽  
Subramanian Sethuraman ◽  
Shanthi Balaji ◽  
VS Kalai Selvi ◽  
AJ Manjula Devi
Keyword(s):  
Down Syndrome ◽  
Retrospective Study ◽  
Growth Velocity ◽  
Thyroid Dysfunction ◽  
Children With Down Syndrome

Myeloid leukaemia in children with down syndrome: Report of the registry-based French experience between 1990 and 2003

2010 ◽  
Vol 54 (7) ◽  
pp. 927-933 ◽  
Author(s):  
Julie Tandonnet ◽  
Jacqueline Clavel ◽  
André Baruchel ◽  
Fabienne Nacka ◽  
Yves Pérel
Keyword(s):  
Down Syndrome ◽  
Myeloid Leukaemia ◽  
Children With Down Syndrome ◽  
French Experience ◽  
Syndrome Report

scholarly journals Nutritional Status and Pulmonary Hypertension in Children with Down Syndrome Presenting with Congenital Heart Disease: Retrospective Study

2020 ◽  
pp. 12-18
Author(s):  
J. M. Chinawa ◽  
O. C. Duru ◽  
B. F. Chukwu ◽  
A. T. Chinawa
Keyword(s):  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Down Syndrome ◽  
Heart Disease ◽  
Retrospective Study ◽  
Nutritional Status ◽  
Congenital Heart ◽  
Children With Down Syndrome ◽  
Increased Risk ◽  
Hypertension In Children

Introduction: Children with Down syndrome are predisposed to having congenital heart defect. Objectives: This study is aimed to describe the clinical correlates, nutritional status and pulmonary hypertension in children with Down syndrome who presented with congenital heart disease. Patients and Methods: A retrospective study of children with Down syndrome who presented with congenital heart disease from 2016 to 2020 was carried out. Nutritional status was assessed with WHO Anthro software while pulmonary hypertension was assessed with standard procedures. Results: Out of 758 echocardiography done over the period of 5 years for children suspected of having cardiac disease, three hundred and eight one had confirmed congenital heart disease of which twenty-eight of them had Down syndrome 7.34% (28/381).  Ten 10/28 (35.7%) of them had pulmonary hypertension. This is commonly noted among infants than older ages. Among 28 children with Down syndrome, twenty-three had complete information for weight and height which was used to assess their nutritional status, 47.8% (11/28) presented with wasting and stunted, 8.7% (2/28) of those with Down syndrome were wasted and 8.7% (2/28) with stunting. Down syndrome is commoner in children with AV canal defect 50% (14/28) followed by PDA 21.4% (6/14). Fast breathing 86.7% (13/15) as the most common symptom followed by cough 64.3% (9/14) Conclusion: Children with Down syndrome who had congenital heart disease are at increased risk of malnutrition and pulmonary hypertension.

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