Renal Cell Carcinoma With Tumor Thrombus Extension Into the Proximal Pulmonary Artery

2003 ◽  
Vol 169 (6) ◽  
pp. 2296-2297 ◽  
Author(s):  
JEFFREY A. WIEDER ◽  
HILLEL LAKS ◽  
DANIELO FREITAS ◽  
A. MARMUREANU ◽  
ARIE BELLDEGRUN
Keyword(s):  
Renal Cell Carcinoma ◽  
Pulmonary Artery ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Thrombus

C229: Treatment of renal cell carcinoma with tumor thrombus in vena cava inferior-own experiences

2014 ◽  
Vol 13 (6) ◽  
pp. e1392
Author(s):  
W. Różański ◽  
M. Markowski ◽  
M. Wrona ◽  
P. Lipiński ◽  
M. Lipiński ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Thrombus ◽  
Vena Cava ◽  
Vena Cava Inferior

Survival analysis of Renal Cell Carcinoma with venous tumor thrombus: A single centre 20-yr experience

2021 ◽  
Vol 79 ◽  
pp. S863
Author(s):  
M.L. Righetto ◽  
M. Mancini ◽  
M. Daniele ◽  
A. Morlacco ◽  
G. Novara ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Survival Analysis ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Thrombus ◽  
Single Centre ◽  
Venous Tumor Thrombus

scholarly journals Sequential immune-targeted surgical therapy resulted in disease-free survival in a case with advanced renal cell carcinoma

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kenichi Nishimura ◽  
Noriyoshi Miura ◽  
Naoya Sugihara ◽  
Keisuke Funaki ◽  
Kanae Koyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Thrombus ◽  
Disease Free Survival ◽  
Sequential Therapy ◽  
Residual Tumor ◽  
Advanced Renal Cell Carcinoma ◽  
Cell Renal Cell Carcinoma ◽  
Disease Free

Abstract Background Currently, immunotherapy is indicated for patients with metastatic RCC or unresectable RCC, but there is no indication for immunotherapy in the neoadjuvant setting. We report a case in which the combined use of nivolumab and ipilimumab and sequential TKI therapy enabled surgical treatment. Case presentation A 71-year-old female was diagnosed with a metastatic clear-cell renal cell carcinoma with a level IV tumor thrombus. She was started on nivolumab-ipilimumab therapy, and was switched to pazopanib monotherapy because the tumor thrombus progressed within the right atrium. The tumor shrank to resectable status with sequential therapy. She then underwent right nephrectomy and thrombectomy. Pathological analysis showed 10–20% residual tumor in the primary tumor, but no viable cells in tumor thrombus. She remains clinically disease-free 1 year after surgery. Conclusion This case suggests the utility of sequential immune-targeted therapy as neoadjuvant therapy in advanced renal cell carcinoma.

scholarly journals Sonographic Evaluation of Inferior Vena Cava Tumor Thrombus in Renal Cell Carcinoma: A Case Study of a Rare Condition

2018 ◽  
Vol 34 (5) ◽  
pp. 375-382
Author(s):  
Viyana Hamblen
Keyword(s):  
Renal Cell Carcinoma ◽  
Inferior Vena Cava ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Wilms Tumor ◽  
Circulatory Arrest ◽  
Vena Cava ◽  
Ivc Tumor

Inferior vena cava (IVC) tumor thrombus in renal cell carcinoma is a rare entity that suggests heightened biologic behavior and a surgical challenge during the course of treatment. Tumor thrombus can extend from the renal vein to the right atrium. This cephalad extension is classified by four different levels. These levels determine which surgical approach is used, whether a thoracoabdominal incision is needed, and whether a patient needs to be placed in circulatory arrest. Complete surgical resection of the tumor is potentially the only curative treatment, although it supposes a challenge because of operative difficulty and the potential for massive bleeding or tumor pulmonary thromboembolism. IVC tumor thrombus presents with a few differentials that need to be assessed, including bland thrombus, primary IVC leiomyosarcoma, hepatocellular carcinoma, adrenal cortical carcinoma, primary lung carcinoma, and Wilms tumor. The importance of diagnosing IVC tumor thrombus secondary to renal cell carcinoma is demonstrated as well as a sonographic protocol for assessing IVC tumor thrombus.

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