No Increased Prostate Cancer Incidence After Negative Transrectal Ultrasound Guided Multiple Biopsies in Men with Increased Prostate Specific Antigen and/or Abnormal Digital Rectal Examination

2003 ◽  
Vol 170 (4 Part 1) ◽  
pp. 1180-1183 ◽  
Author(s):  
ANNA BILL-AXELSON ◽  
LARS HOLMBERG ◽  
BOJOHAN NORLÉN ◽  
CHRISTER BUSCH ◽  
MONA NORBERG
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Cancer Incidence ◽  
Specific Antigen ◽  
Transrectal Ultrasound ◽  
Digital Rectal Examination ◽  
Ultrasound Guided ◽  
Prostate Cancer Incidence ◽  
Rectal Examination ◽  
Multiple Biopsies

Prostate-specific Antigen and Prostate Cancer: How can We Improve Specificity and Predictive Power of the Marker?

1992 ◽  
Vol 59 (4) ◽  
pp. 52-55
Author(s):  
M. Moretti ◽  
A. Cichero ◽  
P. Pittaluga ◽  
M. Varaldo ◽  
Aldo V. Bono ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Specific Antigen ◽  
Transrectal Ultrasound ◽  
Digital Rectal Examination ◽  
Volume Ratio ◽  
Mean Value ◽  
Rectal Examination ◽  
Specificity And Sensitivity ◽  
Multiple Biopsies ◽  
Prostate Cancers

PSA is commonly used in diagnosing prostate cancer but it lacks both specificity and sensitivity; PSA values rise in benign prostatic affections and up to 30% prostate cancers show normal PSA values. Preliminary reports indicate that PSA DENSITY (PSAD), i.e. PSA/prostate-volume ratio, can improve specificity of PSA in diagnosing prostate cancer. We considered PSAD in 55 patients of 160 observed for prostatism: all of them underwent digital rectal examination, transrectal ultrasound and multiple biopsies of the gland. We found cancer in 19 patients (PSAD ranging from 0.17 to 1.77, with a mean value of 0.45), 26 prostatic hyperplasia (PSAD from 0.003 to 0.75, with a mean of 0.13), 6 dysplasia (PSAD from 0.07 to 0.30, with a mean of 0.19). In our experience PSAD > 0.17 or mean value > 0.45 indicate cancer in the absence of significant digital rectal examination and ultrasound findings or normal and borderline PSA values.

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