Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and CD56 Expression in Patients With Type 1 Diabetes Mellitus

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Johan Wadén ◽  
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Lauretta Quinn

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Veselin Škrabić ◽  
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Khadija Al-Ola ◽  
Haya Khayyat ◽  
...  

ABSTRACT Tumor necrosis factor alpha (TNF-α) −308 G/A and lymphotoxin alpha (LTα) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTα +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-α/LTα alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-α/LTα T1DM-susceptible (−308G/+249G) and protective (−308G/+249A) haplotypes were identified.


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