Role of the Thymus in Transplantation Tolerance in Miniature Swine: V. Deficiency of the Graft-to-Thymus Pathway of Tolerance Induction in Recipients of Cardiac Transplants

2006 ◽  
Vol 81 (4) ◽  
pp. 607-613 ◽  
Author(s):  
Shin Yamamoto ◽  
Katsuhito Teranishi ◽  
Chisako Kamano ◽  
Emma Samelson-Jones ◽  
Hitoshi Arakawa ◽  
...  
Keyword(s):  
Tolerance Induction ◽  
Transplantation Tolerance ◽  
Miniature Swine ◽  
Cardiac Transplants

ROLE OF THE THYMUS IN TRANSPLANTATION TOLERANCE IN MINIATURE SWINE

1999 ◽  
Vol 67 (8) ◽  
pp. 1112-1119 ◽  
Author(s):  
Kazuhiko Yamada ◽  
Francesco L. Ierino ◽  
Pierre R. Gianello ◽  
Akira Shimizu ◽  
Robert B. Colvin ◽  
...  
Keyword(s):  
Transplantation Tolerance ◽  
Miniature Swine

ROLE OF THE THYMUS IN TRANSPLANTATION TOLERANCE IN MINIATURE SWINE

1999 ◽  
Vol 67 (3) ◽  
pp. 458-467 ◽  
Author(s):  
Kazuhiko Yamada ◽  
Pierre R. Gianello ◽  
Francesco L. Ierino ◽  
Jonathan Fishbein ◽  
Thomas Lorf ◽  
...  
Keyword(s):  
Transplantation Tolerance ◽  
Miniature Swine

scholarly journals Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction

2016 ◽  
Vol 117 (2) ◽  
pp. 66-83 ◽  
Author(s):  
Priya S. Kishnani ◽  
Patricia I. Dickson ◽  
Laurie Muldowney ◽  
Jessica J. Lee ◽  
Amy Rosenberg ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Tolerance ◽  
Tolerance Induction ◽  
Lysosomal Storage Diseases ◽  
Lysosomal Storage ◽  
Immune Tolerance Induction ◽  
Storage Diseases ◽  
Enzyme Replacement

scholarly journals Vascularized thymic lobe transplantation in miniature swine: Thymopoiesis and tolerance induction across fully MHC-mismatched barriers

2004 ◽  
Vol 101 (11) ◽  
pp. 3827-3832 ◽  
Author(s):  
C. Kamano ◽  
P. A. Vagefi ◽  
N. Kumagai ◽  
S. Yamamoto ◽  
R. N. Barth ◽  
...  
Keyword(s):  
Tolerance Induction ◽  
Miniature Swine ◽  
Thymic Lobe

scholarly journals Cellular adaptations in fat tissue of exercise-trained miniature swine: role of excess energy intake

2000 ◽  
Vol 88 (3) ◽  
pp. 881-887 ◽  
Author(s):  
Gale B. Carey
Keyword(s):  
Adipose Tissue ◽  
Energy Intake ◽  
Excess Energy ◽  
Fat Tissue ◽  
Cellular Mechanisms ◽  
Miniature Swine ◽  
Extracellular Adenosine

This study examined the influence of energy expenditure and energy intake on cellular mechanisms regulating adipose tissue metabolism. 1 Twenty-four swine were assigned to restricted-fed sedentary, restricted-fed exercise-trained, full-fed sedentary, or full-fed exercise-trained groups. After 3 mo of treatment, adipocytes were isolated and adipocyte size, adenosine A1 receptor characteristics, and lipolytic sensitivity were measured. Swine were infused with epinephrine during which adipose tissue extracellular adenosine, plasma fatty acids, and plasma glycerol were measured. Results revealed that adipocytes isolated from restricted-fed exercised swine had a smaller diameter, a lower number of A1 receptors, and a greater sensitivity to lipolytic stimulation, compared with adipocytes from full-fed exercised swine. Extracellular adenosine levels were transiently increased on infusion of epinephrine in adipose tissue of restricted-fed exercised but not full-fed exercised swine. These results suggest a role for adenosine in explaining the discrepancy between in vitro and in vivo lipolysis findings and underscore the notion that excess energy intake dampens the lipolytic sensitivity of adipocytes to β-agonists and adenosine, even if accompanied by exercise training.

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