Evaluation of galectin-3, β-catenin, and nuclear morphometry in different thyroid lesions

2013 ◽  
Vol 33 (2) ◽  
pp. 129-138
Author(s):  
Ahlam A. AbdelMaksoud ◽  
Ghada A. AbdElfattah ◽  
Ranih Z. Amer ◽  
Nashwa M. Emara
Keyword(s):  
Nuclear Morphometry ◽  
Galectin 3 ◽  
Thyroid Lesions

scholarly journals Application of HMWCK, CK19 and Galectin-3 as Immuno Histochemical Markers in the differential diagnosis of thyroid lesions

2020 ◽  
Vol 3 (3) ◽  
pp. 83-88
Author(s):  
Maninder Kaur ◽  
Surinder Paul ◽  
Mandeep Randhawa ◽  
Sumitoj Singh ◽  
Permeet Kaur ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Galectin 3 ◽  
Thyroid Lesions

Diagnostic value of galectin-3 as a marker for malignancy in follicular patterned thyroid lesions

Head & Neck ◽  
2004 ◽  
Vol 26 (11) ◽  
pp. 960-966 ◽  
Author(s):  
Yael Oestreicher-Kedem ◽  
Marisa Halpern ◽  
Pepi Roizman ◽  
Britta Hardy ◽  
Jaqueline Sulkes ◽  
...  
Keyword(s):  
Diagnostic Value ◽  
Galectin 3 ◽  
Thyroid Lesions

scholarly journals Differential expression of Galectin-3 in papillary projections of malignant and non-malignant hyperplastic thyroid lesions

2003 ◽  
Vol 50 (3) ◽  
pp. 67-70 ◽  
Author(s):  
Dubravka Cvejic ◽  
Svetlana Savin-Zegarac ◽  
Ivana Petrovic ◽  
Ivan Paunovic ◽  
Svetislav Tatic ◽  
...  
Keyword(s):  
Thyroid Tissue ◽  
Thyroid Neoplasms ◽  
Graves Disease ◽  
Papillary Thyroid ◽  
Immunohistochemical Technique ◽  
Galectin 3 ◽  
Papillary Hyperplasia ◽  
Malignant Thyroid Neoplasms ◽  
Benign Thyroid ◽  
Thyroid Lesions

Galectin-3 is a a beta-galactoside binding protein recently proposed to be a promising presurgical molecular marker for distinguishing benign from malignant thyroid neoplasms. We analyzed galectin-3 expression immunohistochemically in papillary areas of hyperplastic lesions of benign thyroid tissue in comparison with malignant papillary projections of papillary thyroid carcinoma (PTC). A monoclonal antibody to galectin-3 and ABC immunohistochemical technique were used to evaluate galectin-3 expression in 26 cases of benign papillary hyperplasia (8 cases of hyperplastic adenoma, 8 cases of hyperplastic colloid goiter, 10 cases of Graves disease) in comparison with 25 cases of PTC. Immunohistochemical results showed no reactivity for galectin-3 in papillary areas of benign hyperplastic lesions. Strong cytoplasmic galectin-3 immunoreactivity was found in all 25 cases of PTC. These results show that galectin-3 expression is a feature of malignant papillary projections but not of benign papillary hyperplasia. Thus, the immunohistochemical evaluation of galectin-3 might contribute to differential diagnosis between malignant and benign thyroid lesions with papillary projections.

scholarly journals Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma

2002 ◽  
pp. 515-521 ◽  
Author(s):  
M Papotti ◽  
M Volante ◽  
E Saggiorato ◽  
D Deandreis ◽  
A Veltri ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Papillary Carcinoma ◽  
Correct Diagnosis ◽  
Needle Aspiration ◽  
Immunoperoxidase Staining ◽  
Cytological Examination ◽  
Predictive Values ◽  
Galectin 3 ◽  
Thyroid Lesions

OBJECTIVE: Cystic thyroid lesions can harbour an occult papillary carcinoma, which fine needle aspiration (FNA) biopsy may fail to detect. Recently, new markers such as galectin-3 lectin have been proposed to distinguish benign from malignant thyroid lesions of follicular origin. The aim of this study was to assess the role of galectin-3 immunodetection in a series of FNA cytological samples of benign and malignant thyroid cystic nodules. METHODS: We retrospectively analysed galectin-3 expression by immunoperoxidase staining on 32 cytological paraffin-embedded samples of cystic papillary carcinoma and on 12 samples of benign cysts, both obtained by FNA biopsy. Specificity, sensitivity, positive/negative predictive values, and accuracy of standard cytological examination and galectin-3 immunodetection were assessed. RESULTS: Among cystic papillary carcinomas, 29 of 32 samples were galectin-3 positive, whereas standard FNA cytology made a correct diagnosis in only 25 of 32 samples. All the benign cysts were negative for galectin-3. In comparing the sensitivity and specificity of the two methods, it appeared that both had a 100% specificity, whereas the sensitivity of cytological examination alone was 75% versus 89.3% obtained by galectin-3 immunohistochemistry. CONCLUSIONS: Galectin-3 immunostaining represents a valid pre-operative adjunct to pick up malignant cells in those cases where a very poor number of epithelial cells may lead to a cytological misdiagnosis. Therefore, we suggest that in poorly cellular FNA biopsies of simple or complex thyroid cysts, galectin-3 expression by epithelial cells is consistent with a cystic carcinoma and supports surgical treatment indication.

Galectin‐3 and CD117 immunocytochemistry in the diagnosis of indeterminate thyroid lesions: A pilot study

2021 ◽  
Author(s):  
Sonali Dixit ◽  
Preeti Diwaker ◽  
Neelam Wadhwa ◽  
Vinod K. Arora
Keyword(s):  
Pilot Study ◽  
Galectin 3 ◽  
Thyroid Lesions

Diagnostic value of galectin-3 and hector battifora mesothelial epitope (hbme)-1 as a marker for malignancy in the diagnosis of thyroid lesions

Pathology ◽  
2016 ◽  
Vol 48 ◽  
pp. S122-S123
Author(s):  
Meilany F. Durry ◽  
Upik A. Miskad ◽  
Winny N. Leiwakabessy ◽  
Muh. Husni Cangara
Keyword(s):  
Diagnostic Value ◽  
Galectin 3 ◽  
Thyroid Lesions

scholarly journals Expression of CK-19, galectin-3, and HBME-1 in the differentiation of thyroid lesions: Systematic review and DIAGNOSTIC meta-analysis.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e21151-e21151
Author(s):  
Leandro Luongo Matos ◽  
Adriana Braz Del Giglio ◽  
Carolina MATSUBAYASHI Ogawa ◽  
Michelle de lima Farah ◽  
Maria Aparecida Silva Pinhal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Gland ◽  
Diagnostic Accuracy ◽  
Meta Analysis ◽  
False Negative ◽  
Diagnostic Odds Ratio ◽  
Cytokeratin 19 ◽  
Benign Lesions ◽  
Galectin 3 ◽  
Thyroid Lesions

e21151 Background: The distinction between malignant and benign lesions of the thyroid gland often requires histological demonstration, once the fine-needle aspiration biopsy method applied pre-operatively has some limitations. In an attempt to improve diagnostic accuracy, markers have been studied by immunocyto- and immunohistochemistry techniques, mainly cytokeratin-19 (CK-19), galectin-3 (Gal-3) and Hector Battifora mesothelial-1 (HBME-1). However, current results remain controversial. The aim of the present article was to establish the diagnostic accuracy of CK-19, Gal-3 and HBME-1 markers, as well as their associations, in the differentiation of malignant and benign thyroid lesions. Methods: A systematic review of MEDLINE’s published articles was performed. After establishing the inclusion and exclusion criteria, 65 articles were selected. The technique of meta-analysis of diagnostic accuracy was employed, and global values of sensitivity, specificity, area under the ROC curve (AUC), and diagnostic odds ratio (dOR) were calculated. Results: The positivity ofCK-19 for the diagnosis of malignant thyroid lesions demonstrated sensitivity of 81% (IC95%: 79-83%), specificity of 73% (IC95%: 70-75%), AUC of 87,5% and dOR of 14,7 (IC95%: 8,2-26,4); for Gal-3, sensitivity of 82% (IC95%: 81-84%), specificity of 81% (IC95%: 79-82%), AUC of 90% and dOR of 23,4 (IC95%: 14,0-39,1); and for HBME-1, sensitivity of 77% (IC95%: 76-79%), specificity of 83% (IC95%: 82-85%), AUC of 92,8% and dOR of 41,0 (IC95%: 21,4-78,4). The association of the three markers determined sensitivity of 85% (IC95%: 78-90%), specificity of 97% (IC95%: 90-99%), AUC of 93,3% and dOR of 95,1 (IC95%: 25,2-359,1). Conclusions: The search for new molecular markers must continue in order to enhance the diagnostic accuracy of the differentiation between malignant and benign lesions of the thyroid gland, since the results found still show persistency of false-negative and false-positive tests.

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