scholarly journals Deep Learning-Based Optical Coherence Tomography and Optical Coherence Tomography Angiography Image Analysis: An Updated Summary

2021 ◽  
Vol 10 (3) ◽  
pp. 253-260
Author(s):  
Anran Ran ◽  
Carol Y. Cheung
Keyword(s):  
Optical Coherence Tomography ◽  
Image Analysis ◽  
Deep Learning ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence

scholarly journals Foveal avascular zone segmentation in optical coherence tomography angiography images using a deep learning approach

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Reza Mirshahi ◽  
Pasha Anvari ◽  
Hamid Riazi-Esfahani ◽  
Mahsa Sardarinia ◽  
Masood Naseripour ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Validation Dataset ◽  
Diabetic Patients ◽  
Dice Similarity Coefficient ◽  
Optical Coherence ◽  
Avascular Zone

AbstractThe purpose of this study was to introduce a new deep learning (DL) model for segmentation of the fovea avascular zone (FAZ) in en face optical coherence tomography angiography (OCTA) and compare the results with those of the device’s built-in software and manual measurements in healthy subjects and diabetic patients. In this retrospective study, FAZ borders were delineated in the inner retinal slab of 3 × 3 enface OCTA images of 131 eyes of 88 diabetic patients and 32 eyes of 18 healthy subjects. To train a deep convolutional neural network (CNN) model, 126 enface OCTA images (104 eyes with diabetic retinopathy and 22 normal eyes) were used as training/validation dataset. Then, the accuracy of the model was evaluated using a dataset consisting of OCTA images of 10 normal eyes and 27 eyes with diabetic retinopathy. The CNN model was based on Detectron2, an open-source modular object detection library. In addition, automated FAZ measurements were conducted using the device’s built-in commercial software, and manual FAZ delineation was performed using ImageJ software. Bland–Altman analysis was used to show 95% limit of agreement (95% LoA) between different methods. The mean dice similarity coefficient of the DL model was 0.94 ± 0.04 in the testing dataset. There was excellent agreement between automated, DL model and manual measurements of FAZ in healthy subjects (95% LoA of − 0.005 to 0.026 mm2 between automated and manual measurement and 0.000 to 0.009 mm2 between DL and manual FAZ area). In diabetic eyes, the agreement between DL and manual measurements was excellent (95% LoA of − 0.063 to 0.095), however, there was a poor agreement between the automated and manual method (95% LoA of − 0.186 to 0.331). The presence of diabetic macular edema and intraretinal cysts at the fovea were associated with erroneous FAZ measurements by the device’s built-in software. In conclusion, the DL model showed an excellent accuracy in detection of FAZ border in enfaces OCTA images of both diabetic patients and healthy subjects. The DL and manual measurements outperformed the automated measurements of the built-in software.

OCTAI: Smartphone-based Optical Coherence Tomography Image Analysis System

2021 ◽  
Author(s):  
Adrit Rao ◽  
Harvey A. Fishman
Keyword(s):  
Optical Coherence Tomography ◽  
Image Analysis ◽  
Deep Learning ◽  
Early Stage ◽  
Real Life ◽  
Learning System ◽  
Optical Coherence Tomography Image ◽  
Image Analysis System ◽  
Optical Coherence ◽  
Oct Image

Identifying diseases in Optical Coherence Tomography (OCT) images using Deep Learning models and methods is emerging as a powerful technique to enhance clinical diagnosis. Identifying macular diseases in the eye at an early stage and preventing misdiagnosis is crucial. The current methods developed for OCT image analysis have not yet been integrated into an accessible form-factor that can be utilized in a real-life scenario by Ophthalmologists. Additionally, current methods do not employ robust multiple metric feedback. This paper proposes a highly accurate smartphone-based Deep Learning system, OCTAI, that allows a user to take an OCT picture and receive real-time feedback through on-device inference. OCTAI analyzes the input OCT image in three different ways: (1) full image analysis, (2) quadrant based analysis, and (3) disease detection based analysis. With these three analysis methods, along with an Ophthalmologist's interpretation, a robust diagnosis can potentially be made. The ultimate goal of OCTAI is to assist Ophthalmologists in making a diagnosis through a digital second opinion and enabling them to cross-check their diagnosis before making a decision based on purely manual analysis of OCT images. OCTAI has the potential to allow Ophthalmologists to improve their diagnosis and may reduce misdiagnosis rates, leading to faster treatment of diseases.

scholarly journals Machine learning in optical coherence tomography angiography

2021 ◽  
pp. 153537022110265
Author(s):  
David Le ◽  
Taeyoon Son ◽  
Xincheng Yao
Keyword(s):  
Machine Learning ◽  
Optical Coherence Tomography ◽  
Image Analysis ◽  
Human Error ◽  
Optical Coherence Tomography Angiography ◽  
Disease Classification ◽  
Optical Coherence ◽  
Label Free ◽  
Machine Learning Classification ◽  
Recent Developments

Optical coherence tomography angiography (OCTA) offers a noninvasive label-free solution for imaging retinal vasculatures at the capillary level resolution. In principle, improved resolution implies a better chance to reveal subtle microvascular distortions associated with eye diseases that are asymptomatic in early stages. However, massive screening requires experienced clinicians to manually examine retinal images, which may result in human error and hinder objective screening. Recently, quantitative OCTA features have been developed to standardize and document retinal vascular changes. The feasibility of using quantitative OCTA features for machine learning classification of different retinopathies has been demonstrated. Deep learning-based applications have also been explored for automatic OCTA image analysis and disease classification. In this article, we summarize recent developments of quantitative OCTA features, machine learning image analysis, and classification.

scholarly journals Deep learning differentiates between healthy and diabetic mouse ears from optical coherence tomography angiography images

2021 ◽  
Author(s):  
Martin Pfister ◽  
Hannes Stegmann ◽  
Kornelia Schützenberger ◽  
Bhavapriya Jasmin Schäfer ◽  
Christine Hohenadl ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Deep Learning ◽  
Optical Coherence Tomography Angiography ◽  
Diabetic Mouse ◽  
Optical Coherence
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