ONO-1301 Enhances in vitro Osteoblast Differentiation and in vivo Bone Formation Induced by Bone Morphogenetic Protein

Spine ◽  
2018 ◽  
Vol 43 (11) ◽  
pp. E616-E624 ◽  
Author(s):  
Sadaaki Kanayama ◽  
Takashi Kaito ◽  
Kazuma Kitaguchi ◽  
Hiroyuki Ishiguro ◽  
Kunihiko Hashimoto ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Osteoblast Differentiation ◽  
Morphogenetic Protein ◽  
In Vivo Bone Formation

Bone Morphogenetic Protein 2 and Retinoic Acid Accelerate in Vivo Bone Formation, Osteoclast Recruitment, and Bone Turnover

2005 ◽  
Vol 11 (3-4) ◽  
pp. 645-658 ◽  
Author(s):  
Catherine M. Cowan ◽  
Oliver O. Aalami ◽  
Yun-Ying Shi ◽  
Yu-Fen Chou ◽  
Carina Mari ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Bone Formation ◽  
Bone Turnover ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
In Vivo Bone Formation

scholarly journals Umbilical Cord Mesenchymal Stem Cell-Derived Nanovesicles Potentiate the Bone-Formation Efficacy of Bone Morphogenetic Protein 2

2020 ◽  
Vol 21 (17) ◽  
pp. 6425
Author(s):  
Songhyun Lim ◽  
Hao-Zhen Lyu ◽  
Ju-Ro Lee ◽  
Shi Huan Han ◽  
Jae Hyup Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Umbilical Cord ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Calvarial Defects ◽  
In Vivo Bone Formation

Recombinant human bone morphogenetic protein 2 (rhBMP-2) is one of the most potent osteogenic factors used to treat bone loss. However, at higher doses, rhBMP-2 does not necessarily increase bone formation but rather increases the incidence of adverse side effects. Here, we investigated whether umbilical cord mesenchymal stem cell (UCMSC)-derived nanovesicles (NVs) further increase the in vivo bone formation at high doses of rhBMP-2. In the presence of UCMSC-derived NVs, proliferation, migration, and tube formation of human umbilical vein endothelial cells were stimulated in vitro. Furthermore, migration and osteogenesis of human bone marrow-derived mesenchymal stem cells were stimulated. To examine the efficacy of UCMSC-derived NVs on in vivo bone formation, collagen sponges soaked with rhBMP-2 and UCMSC-derived NVs were used in athymic nude mice with calvarial defects. At a high rhBMP-2 dosage (500 ng/mL), UCMSC-derived NVs significantly promoted bone formation in calvarial defects; however, the UCMSC-derived NVs alone did not induce in vivo bone formation. Our results indicate that UCMSC-derived NVs can potentiate the bone formation efficacy of rhBMP-2 at a high dosage.

scholarly journals Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced In Vivo Bone Formation

2019 ◽  
Vol 25 (13-14) ◽  
pp. 1037-1052 ◽  
Author(s):  
Maurits G.L. Olthof ◽  
Diederik H.R. Kempen ◽  
Xifeng Liu ◽  
Mahrokh Dadsetan ◽  
Marianna A. Tryfonidou ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Electrical Charge ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
In Vivo Bone Formation

Casein kinase 2 regulates in vivo bone formation through its interaction with bone morphogenetic protein receptor type Ia

Bone ◽  
2011 ◽  
Vol 49 (5) ◽  
pp. 944-954 ◽  
Author(s):  
Beth Bragdon ◽  
Shayamala Thinakaran ◽  
Oleksandra Moseychuk ◽  
Lauren Gurski ◽  
Jeremy Bonor ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Casein Kinase ◽  
Receptor Type ◽  
Bone Morphogenetic Protein Receptor ◽  
Protein Receptor ◽  
Morphogenetic Protein ◽  
Type Ia ◽  
In Vivo Bone Formation
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