Endpoints and surrogate endpoints in colorectal cancer: a review of recent developments

2008 ◽  
Vol 20 (4) ◽  
pp. 466-471 ◽  
Author(s):  
Pascal Piedbois ◽  
Marc Buyse
Keyword(s):  
Colorectal Cancer ◽  
Surrogate Endpoints ◽  
Recent Developments

scholarly journals Recent advances in understanding Lynch syndrome

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2889 ◽  
Author(s):  
Sherief Shawki ◽  
Matthew F. Kalady
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Correct Diagnosis ◽  
Diagnostic Testing ◽  
Gene Mutations ◽  
The United States ◽  
Cancer Syndrome ◽  
Dna Mismatch ◽  
Recent Developments ◽  
Risk Patients

Colorectal cancer affects about 4.4% of the population and is a leading cause of cancer-related death in the United States. Approximately 10% to 20% of cases occur within a familial pattern, and Lynch syndrome is the most common hereditary colorectal cancer syndrome. Lynch syndrome is a hereditary predisposition to forming colorectal and extracolonic cancers, caused by a germline mutation in one of the DNA mismatch repair genes. Identifying at-risk patients and making a correct diagnosis are the keys to successful screening and interventions which will decrease formation of and death from cancers. Knowledge of the genetics and the natural history of Lynch syndrome has continued to be uncovered in recent years, leading to a better grasp on how these patients and their families should be managed. Recent developments include the approach to diagnostic testing, more precise definitions of the syndrome and risk stratification based on gene mutations, surgical decision-making, and chemoprevention.

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives

2013 ◽  
Vol 62 (8) ◽  
pp. 1107-1123 ◽  
Author(s):  
Imen Kahouli ◽  
Catherine Tomaro-Duchesneau ◽  
Satya Prakash
Keyword(s):  
Colorectal Cancer ◽  
Early Stage ◽  
Tumour Progression ◽  
Great Promise ◽  
Anticancer Compounds ◽  
Beneficial Effects ◽  
Physico Chemical ◽  
Recent Developments ◽  
Chemical Conditions

Colorectal cancer (CRC) is the third most common form of cancer. Diverse therapies such as chemotherapy, immunotherapy and radiation have shown beneficial effects, but are limited because of their safety and toxicity. Probiotic formulations have shown great promise in CRC as preventive and early stage therapeutics. This review highlights the importance of a balanced intestinal microbiota and summarizes the recent developments in probiotics for treating CRC. Specifically, this report describes evidence of the role of probiotics in modulating the microbiota, in improving the physico-chemical conditions of the gut and in reducing oxidative stress. It also discusses the mechanisms of probiotics in inhibiting tumour progression, in producing anticancer compounds and in modulating the host immune response. Even though some of these effects were observed in several clinical trials, when probiotic formulations were used as a supplement to CRC therapies, the application of probiotics as biotherapeutics against CRC still needs further investigation.

Recent Developments in Hereditary Nonpolyposis Colorectal Cancer

1996 ◽  
Vol 31 (sup218) ◽  
pp. 92-97 ◽  
Author(s):  
M. E. Craanen ◽  
P. Bzlok ◽  
O. J. A. Offerhaus ◽  
G. N. J. Tytoat
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis ◽  
Recent Developments

scholarly journals Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis

2017 ◽  
Vol 49 (3) ◽  
pp. 834-845 ◽  
Author(s):  
Chiara Cremolini ◽  
Carlotta Antoniotti ◽  
Filippo Pietrantonio ◽  
Rosa Berenato ◽  
Marco Tampellini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Metastatic Colorectal Cancer ◽  
Meta Analysis ◽  
Surrogate Endpoints ◽  
Second Line ◽  
Targeted Agents

Recent developments in antibody derivatives against colorectal cancer; A review

Life Sciences ◽  
2021 ◽  
Vol 265 ◽  
pp. 118791
Author(s):  
Sepideh Ghani ◽  
Samira Bahrami ◽  
Behnam Rafiee ◽  
Shirin Eyvazi ◽  
Fatemeh Yarian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Recent Developments ◽  
Antibody Derivatives
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