scholarly journals Analysis of nickel distribution by synchrotron radiation X-ray fluorescence in nickel-induced early- and late-phase allergic contact dermatitis in Hartley guinea pigs

2019 ◽  
Vol 132 (16) ◽  
pp. 1959-1964
Author(s):  
Shan-Qun Jiang ◽  
Xiang-Yu Wu ◽  
Jin-Lyu Sun ◽  
Guang Chen ◽  
Rui Tang ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Synchrotron Radiation ◽  
Allergic Contact Dermatitis ◽  
Guinea Pigs ◽  
Late Phase ◽  
X Ray ◽  
Allergic Contact ◽  
Nickel Distribution

scholarly journals Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by DNFB.

Ensho ◽  
1993 ◽  
Vol 13 (6) ◽  
pp. 571-574
Author(s):  
Yoko Shoji ◽  
Tadashi Fukumura ◽  
Toshitaka Kudo ◽  
Akira Yanagawa ◽  
Jingoro Shimada ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Mycophenolic Acid ◽  
Guinea Pigs ◽  
Topical Preparation ◽  
Allergic Contact ◽  
Experimental Allergic

scholarly journals Synthese von seitenkettenmodifizierten Analogen des Allergens Primin / Synthesis of Side-Chain-Modified Analogues of the Allergen Primin

1993 ◽  
Vol 48 (3) ◽  
pp. 387-393 ◽  
Author(s):  
Wilfried A. König. ◽  
Holger Faasch ◽  
Holger Heitsch ◽  
Cornelia Colberg ◽  
Björn M. Hausen
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Chain Length ◽  
Guinea Pigs ◽  
Chemical Structure ◽  
Alkyl Chain ◽  
Maximum Activity ◽  
Side Chain ◽  
Allergic Contact ◽  
The Relationship

Benzoquinones such as primin (2-methoxy-6-pentyl-1,4-benzoquinone) from Primula obconica HANCE (Primulaceae) are known to be strong sensitizers and thus the source of severe allergic contact dermatitis (cell-mediated type of allergy). In order to determine the relationship between sensitizing capacity and chemical structure the synthesis of 19 side-chain-modified analogues of primin was carried out. With each of these primin derivatives 10 guinea pigs were sensitized using a modified FCA-method (FCA = Freund’s complete adjuvant). Elicitation was done open epicutaneously with 0.001 molar concentrations. In these sensitization experiments 2-methoxy-6-alkyl-1,4-benzoquinones (chain length C1-C15) showed ascending sensitizing potency with increasing number of the side chain carbon atoms reaching maximum activity at an alkyl chain of 10 to 11 carbons. Beyond this point a decrease of the sensitizing potency in correlation with a further prolongation of the side chain was observed.

Synthesis of and allergic contact dermatitis to bicyclo-[2,2,1]-heptyl-α-methylene-γ-butyrolactones derived from norbornene and camphene

1978 ◽  
Vol 56 (3) ◽  
pp. 153-157 ◽  
Author(s):  
Gilbert Schlewer ◽  
Jean-Luc Stampf ◽  
Claude Benezra
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Guinea Pigs ◽  
Human Volunteer ◽  
Allergic Contact

Three new lactones, 2-oxo-3-methylene-4,7-methanobenzofuran and two α-methylene spirolactones, 3′,3′-dimethylspiro(2-oxo-3-methylenefuran-5,2′-norbornane), were synthesized and their skin activity was tested on one human volunteer and on guinea pigs. The man, sensitized to Frullania, was found sensitive to the above lactones and also reacted to frullanolide and alantolactone. The guinea pigs, experimentally sensitized to alantolactone, cross-reacted to 2-oxo-3-methylene-4,7-methanobenzofuran and the two α-methylene spirolactones, and also to isolantolactone and frullanolide.

MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis

2017 ◽  
Vol 34 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Weihua Mai ◽  
Dongqing Lu ◽  
Xingwei Liu ◽  
Ling Chen
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Messenger Rna ◽  
Late Phase ◽  
Nickel Sulfate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Leucocyte Migration ◽  
Nickel Exposure ◽  
Temporal Expression Pattern ◽  
Allergic Contact

To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled. Skin biopsies from the positive nickel-challenged sites at different time points were assessed by immunohistochemistry (IHC) for MCP-1, CD68, CD45RO, and in situ hybridization (ISH) for MCP-1, using chronic periumbilical dermititis as controls. The expressions of MCP-1 in HaCaT cell culture after nickel treatment were quantified by enzyme-linked immunosorbent assay. The results showed that at positive nickel-challenged sites, strong expressions of MCP-1, both messenger RNA (mRNA) and protein, were detected in the basal keratinocytes during the early phase (24–48 h after nickel application), paralleled by the recruitment of CD68+ and CD45RO+ cells to the skin compartments. The expressions of MCP-1 declined gradually in the late phase (72–96 h after nickel application). Treatment with nickel sulfate at noncytotoxic concentrations (0.01–100 µM) induced a concentration-related elevation of MCP-1 expression by HaCaT cells compared to the untreated cells. The data indicated that a temporal expression pattern of MCP-1 produced by keratinocytes after nickel exposure was involved in the complex process of mononuclear cell infiltration during elicitation of nickel-induced OACD. Targeting MCP-1 might be a potential therapeutic strategy for OACD.

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